Anthropometric Measurements as Predictors of Low Birth Weight Among Tanzanian Neonates: A Hospital-Based Study
November 7, 2025
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Brand Name :
Tikosyn
Synonyms :
dofetilide
Class :
Antiarrhythmic agent, Class III
Brand Name :
Tikosyn
Synonyms :
dofetilide
Class :
Antiarrhythmic agent, Class III
Dosage Forms & Strengths
Capsule, Oral:
125 mcg
250 mcg
500 mcg
500
mcg
Capsule
oral
twice a day
Supraventricular Tachycardia (SVT)
500
mcg
Capsule
Oral
twice a day
Supraventricular Tachycardia (SVT)
500
mcg
Capsule
Oral
twice a day
Ureteral stones:
10
mg
Capsule
Oral
once a day
; discontinue after expulsion (generally within 1 to 2 weeks)
Note: Not enough study conducted for stones >10 mm
Dose Adjustments
CrCl 30-50 ml/minute: 4 mg once a day
CrCl <30 ml/minute and severe hepatic impairment: Contraindicated (Use prohibited)
No safe and efficacious dosing is available
Refer to adult dosing
dofetilide: they may increase the QTc-prolonging effect when combined with thiazide
dofetilide: they may increase the QTc-prolonging effect when combined with thiazide
dofetilide: they may increase the QTc-prolonging effect when combined with thiazide
dofetilide: they may increase the QTc-prolonging effect when combined with thiazide
It may enhance QTc interval when combined with pentamidine
lidocaine’s pharmacodynamic synergism enhance the dofetilide effects
may increase the QTc-prolonging effect of hydrochlorothiazide
It may enhance QTc interval when combined with efavirenz
when both drugs are combined, there may be an increased risk or severity of QTC prolongation
QTc interval is increased both by lenvatinib and dofetilide
when both drugs are combined, both increase the QTC interval
dofetilide and gilteritinib, when used in combination, increase the QTc interval
trimethoprim enhances the concentration of dofetilide in serum
may increase toxicity of the drug by decreasing the renal clearance
may increase the QTc interval when combined
trimethoprim: they may enhance the serum concentration of dofetilide
may enhance the concentration of serum when combined with dofetilide
may enhance the concentration of serum when combined with dofetilide
may enhance the concentration of serum when combined with dofetilide
may enhance the concentration of serum when combined with dofetilide
may enhance the concentration of serum when combined with dofetilide
dofetilide: they may enhance the serum concentration of CYP3A Inhibitors
dofetilide: they may enhance the serum concentration of CYP3A Inhibitors
dofetilide: they may enhance the serum concentration of CYP3A Inhibitors
dofetilide: they may enhance the serum concentration of CYP3A Inhibitors
dofetilide: they may enhance the serum concentration of CYP3A Inhibitors
it may enhance the metabolism when combined with oxcarbazepine
When dofetilide is used together with givinostat, this leads to enhanced risk or seriousness of Qtc prolongation
When dofetilide is used together with oleandomycin, this leads to enhanced concentration serum of dofetilide
When dofetilide is used together with ridaforolimus, this leads to enhanced concentration serum of dofetilide
metformin increases the concentration of dofetilide in the serum
may enhance the serum concentration of CYP3A4 inhibitors
may increase the CNS depressant effect of CNS Depressants
loop diuretics have the potential to amplify the QTc-prolonging effect of dofetilide
loop diuretics have the potential to amplify the QTc-prolonging effect of dofetilide
loop diuretics have the potential to amplify the QTc-prolonging effect of dofetilide
Frequency defined:
>10%
Headache
1% to 10%
Bradycardia
Abdominal pain
Diarrhea
Dyspepsia
Nausea
Vomiting
Asthenia
Skin photosensitivity
Back pain
Postmarketing
Atrial flutter
Heart failure
Anaphylaxis
Angioedema
Pregnancy consideration: Few adverse effects were reported in animal reproductive studies. Contradicted for pregnant women.
Lactation: excretion of dofetilide in breast milk is not known.
Pregnancy category:
Patient information leaflet
Generic Name: Dofetilide
Pronounced: dofetilide
Why do we use dofetilide?
Dofetilide is used for the treatment of atrial fibrillation.
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