ADHD Treatments Under the Spotlight: Weighing Benefits and Harms
November 28, 2025
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Brand Name :
pifletro
Synonyms :
doravirinum
Class :
HIV, Non-nucleoside reverse transcriptase inhibitors
Brand Name :
pifletro
Synonyms :
doravirinum
Class :
HIV, Non-nucleoside reverse transcriptase inhibitors
Dosage Forms & Strengths
Tablet
100mg
Indicated for the treatment of HIV-1 infection in patients in combination with other antiretrovirals
100mg orally every day
Dosage Forms & Strengths
Tablet
100mg
Exercise caution while administering medication to older individuals
it decreases by affecting the hepatic enzyme CYP3A4 metabolism
it decreases by affecting the hepatic enzyme CYP3A4 metabolism
it decreases by affecting the hepatic enzyme CYP3A4 metabolism
it decreases by affecting the hepatic enzyme CYP3A4 metabolism
it decreases by affecting the hepatic enzyme CYP3A4 metabolism
When naficillin combines with doravirine, nafcillin will decrease the effect of action of doravirine by affecting enzyme CYP3A4 metabolism.
when both drugs are combined, there may be a decreased effect of doravirine by affecting hepatic or intestinal enzyme cyp3a4 metabolism
rifabutin: they may diminish the serum concentration of doravirine
may diminish the rate of excretion which could result in a higher serum level
may diminish the rate of excretion leading to a higher serum level
may diminish the rate of excretion leading to a higher serum level
may diminish the rate of excretion leading to a higher serum level
may diminish the rate of excretion leading to a higher serum level
may diminish the rate of excretion leading to a higher serum level
they decrease the concentration of doravirine in the serum
they decrease the concentration of doravirine in the serum
they decrease the concentration of doravirine in the serum
they decrease the concentration of doravirine in the serum
they decrease the concentration of doravirine in the serum
it increases by affecting the hepatic enzyme CYP3A4 metabolism
it increases by affecting the hepatic enzyme CYP3A4 metabolism
it increases by affecting the hepatic enzyme CYP3A4 metabolism
CYP3A strong enhancers of the small intestine may reduce the bioavailability of doravirine
it decreases the concentration of doravirine in the serum
it increases by affecting the hepatic enzyme CYP3A4 metabolism
it decreases by affecting the hepatic enzyme CYP3A4 metabolism
it increases by affecting the hepatic enzyme CYP3A4 metabolism
it increases by affecting the hepatic enzyme CYP3A4 metabolism
it increases by affecting the hepatic enzyme CYP3A4 metabolism
it increases by affecting the hepatic enzyme CYP3A4 metabolism
it increases by affecting the hepatic enzyme CYP3A4 metabolism
it increases by affecting the hepatic enzyme CYP3A4 metabolism
it increases by affecting the hepatic enzyme CYP3A4 metabolism
it increases by affecting the hepatic enzyme CYP3A4 metabolism
it increases by affecting the hepatic enzyme CYP3A4 metabolism
it increases by affecting the hepatic enzyme CYP3A4 metabolism
It may enhance the metabolism when combined with dexamethasone
doravirine: it may decrease the metabolism of gestodene
the effect of doravirine is decreased by lorlatinib, by altering intestinal or hepatic CYP3A4 enzyme metabolism
by altering intestinal/hepatic CYP 3A4 metabolism, the activity of doravirine can be reduced by butabarbital
the activity of the anthrax vaccine can be reduced when used in combination with doravirine
it increases by affecting the hepatic enzyme CYP3A4 metabolism
it increases by affecting the hepatic enzyme CYP3A4 metabolism
it increases by affecting the hepatic enzyme CYP3A4 metabolism
Frequency defined:
1-10%
Fatigue
Rash
Abnormal dreams
Nausea
Diarrhea
Headache
Insomnia
AST≥5x ULN
ALT 2.5 to <5x ULN
Lipase 1.5 to <3x ULN
Creatinine >1.3 to 1.8
Creatinine kinase≥10x ULN
Creatinine kinase 6 to <10x ULN
<1%
LDL cholesterol fasted ≥190mg/dL
AST≥5x ULN
Pregnancy consideration: Insufficient data is available
Lactation: Excretion of the drug in human breast milk is unknown
Pregnancy category:
Patient information leaflet
Generic Name: doravirin
Pronounced: DOR-a-VIR-een
Why do we use doravirin?
Antiviral medication stops the human immunodeficiency virus (HIV) from spreading throughout your body.
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