Microplastics and Misinformation: What Science Really Says
November 12, 2025
Free CME credits
Both our subscription plans include Free CME/CPD AMA PRA Category 1 credits.
Brand Name :
No Data Available.
Synonyms :
entacapone
Class :
Antiparkinson Agents, COMT Inhibitors
Brand Name :
No Data Available.
Synonyms :
entacapone
Class :
Antiparkinson Agents, COMT Inhibitors
Dosage Forms & Strengths:
Tablet
200mg
Parkinson Disease
200 mg orally with each dose of levodopa/carbidopa maximum up to 8 times per day
Do not exceed the dose up to 1600 mg per day
Renal Impairment
Dose adjustment is not required
Hepatic Impairment
Dose adjustment is not required
200
mg
Orally
with each dose of levodopa/carbidopa maximum up to 8 times per day
Do not exceed the dose up to 1600 mg per day
Dose Adjustments
Renal Impairment
Dose adjustment is not required
Hepatic Impairment
Dose adjustment is not required
may diminish concentration of serum when combined with entacapone
may diminish concentration of serum when combined with entacapone
may diminish concentration of serum when combined with entacapone
may diminish concentration of serum when combined with entacapone
may have an increasingly adverse effect when combined with MAO inhibitors
may have an increasingly adverse effect when combined with MAO inhibitors
may have an increasingly adverse effect when combined with MAO inhibitors
may have an increasingly adverse effect when combined with MAO inhibitors
may have an increasingly adverse effect when combined with MAO inhibitors
may have an increasingly adverse effect when combined with MAO inhibitors
may diminish the serum concentration of iron preparations
may enhance the adverse/toxic effect of MOA inhibitors
may enhance the adverse/toxic effect of MOA inhibitors
may enhance the adverse/toxic effect of MOA inhibitors
may enhance the adverse/toxic effect of MOA inhibitors
may enhance the adverse/toxic effect of MOA inhibitors
It may enhance the serum concentration when combined with COMT Substrates
It may enhance the serum concentration when combined with COMT Substrates
It may enhance the serum concentration when combined with COMT Substrates
It may enhance the serum concentration when combined with COMT Substrates
When entacapone is used together with melitracen, this leads to enhanced risk or seriousness of CNS depression
When acepromazine is used together with entacapone, this leads to enhanced risk or seriousness of CNS depression
sapropterin may increase the risk of adverse/toxic effect of levodopa-containing products
may increase the risk of adverse effect
may increase the risk of adverse effect
may increase the risk of adverse effect
may increase the risk of adverse effect
may increase the risk of adverse effect
may increase the risk of adverse effect
may increase the risk of adverse effect
may increase the risk of adverse effect
may increase the risk of adverse effect
may increase the risk of adverse effect
may enhance the serum concentration of COMT Substrates
It may enhance the serum concentration when combined with COMT Substrates
It may enhance the serum concentration when combined with COMT Substrates
It may enhance the serum concentration when combined with COMT Substrates
It may enhance the serum concentration when combined with COMT Substrates
may diminish the therapeutic effect of the drug
may diminish the therapeutic effect of the drug
may diminish the therapeutic effect of the drug
may diminish the therapeutic effect of the drug
may diminish the therapeutic effect of the drug
may diminish the therapeutic effect of the drug
may diminish the therapeutic effect of the drug
may diminish the therapeutic effect of the drug
may diminish the therapeutic effect of the drug
may diminish the therapeutic effect of the drug
may diminish the therapeutic effect of the drug
may diminish the therapeutic effect of the drug
may diminish the therapeutic effect of the drug
may diminish the therapeutic effect of the drug
may diminish the therapeutic effect of the drug
may diminish the therapeutic effect of the drug
may diminish the therapeutic effect of the drug
may diminish the therapeutic effect of the drug
may diminish the therapeutic effect of the drug
may diminish the therapeutic effect of the drug
may diminish the therapeutic effect of the drug
may diminish the therapeutic effect of the drug
may diminish the therapeutic effect of the drug
may diminish the therapeutic effect of the drug
may diminish the therapeutic effect of the drug
may diminish the therapeutic effect of the drug
may diminish the therapeutic effect of the drug
may diminish the therapeutic effect of the drug
may diminish the therapeutic effect of the drug
may diminish the therapeutic effect of the drug
may diminish the therapeutic effect of the drug
may diminish the therapeutic effect of the drug
may diminish the therapeutic effect of the drug
Levodopa plasma levels are higher and longer lasting when entacapone is administered in combination with levodopa and an aromatic amino acid decarboxylase inhibitor.
These longer-lasting levodopa plasma levels are thought to produce more consistent dopaminergic activation in the brain at a specific frequency of levodopa administration, which in turn reduces the symptoms of parkinsonian syndrome.
Adverse drug reactions:
Frequency defined:
>10%
Hyperkinesia
Dyskinesia
Nausea
Diarrhea
Urine discoloration
1-10%
Back pain
Vomiting
Dry mouth
Hypokinesia
Dizziness
Abdominal pain
Fatigue
Dyspnea
Increased sweating
Agitation
Gastritis
Bacterial infection
Flatulence
Purpura
Asthenia
Hallucinations
Taste perversion
Frequency Not Defined
Postural hypotension
Confusion
Insomnia
None
Contraindication:
Hypersensitivity
Caution:
Not for coadministration with a non-selective MAO inhibitor
Hyperpyrexia and confusion
Fibrotic complications
Compulsive behaviour
Diarrhea and colitis
Hallucinations and psychotic-like behaviour
Pregnancy warnings:
US FDA pregnancy category: C
Breastfeeding warnings:
The release of the drug into the human breastmilk is unknown
Pregnancy Categories:
Category A: Satisfactory and well-controlled studies show no risk to the fetus in the first or later trimester.
Category B: No evidence shown of risk to the fetus found in animal reproduction studies, and there are not enough studies on pregnant women
Category C: Adverse effects on the fetus found with evidence in animal reproduction studies and no adequate evidence for a result in humans must take care of potential risks in pregnant women
Category D: There is adequate data available with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits
Category X: Drugs listed in this category outweigh risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.
Category N: There is no data available for the drug under this category
Tolcapone and entacapone share structural and pharmacological similarities, but entacapone does not have a hepatotoxic effect.
Entacapone inhibits catechol-O-methyltransferase (COMT) in a selective and reversible manner.
The methyl group of S-adenosyl-L-methionine is transferred to the phenolic group of substrates with a catechol structure by COMT.
COMT is responsible for the removal of several additional hydroxylated metabolites and physiologically active catechol.
Swallow the tablet whole with water.
It can be taken with or without food.
It is always taken together with levodopa/carbidopa combination.
It should be taken at the same time as each dose of levodopa/carbidopa.
Patient information leaflet
Generic Name: entacapone
Why do we use entacapone?
Entacapone is used in combination with levodopa and carbidopa to treat idiopathic Parkinson’s disease symptoms.
It helps manage “wearing off” symptoms, where the effects of levodopa start to decrease before the next dose is due.
Both our subscription plans include Free CME/CPD AMA PRA Category 1 credits.
On course completion, you will receive a full-sized presentation quality digital certificate.
A dynamic medical simulation platform designed to train healthcare professionals and students to effectively run code situations through an immersive hands-on experience in a live, interactive 3D environment.
When you have your licenses, certificates and CMEs in one place, it's easier to track your career growth. You can easily share these with hospitals as well, using your medtigo app.
