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January 27, 2026
Brand Name :
ventavis
Synonyms :
iloprost
Class :
Anti-thrombotic agents, Platelet aggregation inhibitors
Dosage Forms & Strengths
Single-use ampoule
10mcg/ml
20mcg/ml
Pulmonary Arterial Hypertension
Initial
:
Solution
Orally inhaled
inhale 2.5mcg then 5mcg in subsequent dose,6-9 times every day when necessary
Maintenance:2.5-5mcg/dose. Do not exceed 45mcg/day
may enhance the hypotensive effect of Blood Pressure Lowering Agents
may enhance the hypotensive effect of Blood Pressure Lowering Agents
may enhance the hypotensive effect of Blood Pressure Lowering Agents
may enhance the hypotensive effect of Blood Pressure Lowering Agents
may enhance the hypotensive effect of Blood Pressure Lowering Agents
thrombolytic Agents may enhance the adverse/toxic effect of prostacyclin Analogues
may enhance the adverse/toxic effect of anticoagulants
may enhance the adverse/toxic effect of anticoagulants
may enhance the adverse/toxic effect of anticoagulants
may enhance the adverse/toxic effect of anticoagulants
may enhance the adverse/toxic effect of anticoagulants
may increase the hypotensive effect of blood pressure lowering agents
may increase the hypotensive effect of antihypertensives
may increase the antiplatelet effect of prostacyclin analogs
may increase the antiplatelet effect of prostacyclin analogs
may increase the antiplatelet effect of prostacyclin analogs
may increase the antiplatelet effect of prostacyclin analogs
may increase the antiplatelet effect of prostacyclin analogs
may increase the toxic effect of prostacyclin analogs
may increase the toxic effect of prostacyclin analogs
may increase the toxic effect of prostacyclin analogs
may increase the toxic effect of prostacyclin analogs
may increase the toxic effect of prostacyclin analogs
may increase the hypotensive effect of antihypertensives
may increase the hypotensive effect of antihypertensives
may increase the hypotensive effect of antihypertensives
may increase the hypotensive effect of antihypertensives
may increase the hypotensive effect of antihypertensives
may increase the hypotensive effect of antihypertensives
may increase the hypotensive effect of antihypertensives
may increase the hypotensive effect of antihypertensives
may increase the hypotensive effect of antihypertensives
may increase the hypotensive effect of antihypertensives
may increase the hypotensive effect of antihypertensives
may increase the hypotensive effect of antihypertensives
may increase the hypotensive effect of antihypertensives
may increase the hypotensive effect of antihypertensives
may increase the hypotensive effect of antihypertensives
may increase the hypotensive effect of antihypertensives
may increase the hypotensive effect of antihypertensives
may increase the toxic effects of prostacyclin analogs
may have an increased antiplatelet effect when combined with antiplatelet agents
may have an increased antiplatelet effect when combined with antiplatelet agents
may have an increased antiplatelet effect when combined with antiplatelet agents
may have an increased antiplatelet effect when combined with antiplatelet agents
may have an increased antiplatelet effect when combined with antiplatelet agents
may have an increased adverse effect when combined with anticoagulants
may have an increased adverse effect when combined with anticoagulants
may have an increased adverse effect when combined with anticoagulants
may have an increased adverse effect when combined with anticoagulants
may have an increased adverse effect when combined with anticoagulants
may have an increased hypotensive effect when combined with anti-hypertensive agents
may have an increased hypotensive effect when combined with anti-hypertensive agents
may have an increased hypotensive effect when combined with anti-hypertensive agents
may have an increased hypotensive effect when combined with anti-hypertensive agents
may have an increased hypotensive effect when combined with anti-hypertensive agents
may have an increased adverse effect when combined with prostacyclin analogues
may have an increased hypotensive effect when combined with antihypertensive drugs
prostacyclin analogues: they may increase the hypotensive effect when combined with blood viscosity-reducing agents
prostacyclin analogues: they may increase the hypotensive effect when combined with blood viscosity-reducing agents
prostacyclin: they may increase the antiplatelet effect of antiplatelet agents
prostacyclin: they may increase the antiplatelet effect of antiplatelet agents
may have an increased antiplatelet effect when combined with antiplatelet agents
may have an increased antiplatelet effect when combined with antiplatelet agents
may increase the hypotensive effect of antihypertensives
may enhance the toxic effect of anti-coagulants
may increase the hypotensive effect of calcium channel blockers
may increase the hypotensive effect of calcium channel blockers
lisinopril/hydrochlorothiazide
may increase the hypotensive effect of blood pressure-lowering agents
eprosartan/hydrochlorothiazide
may increase the hypotensive effect of blood pressure-lowering agents
may increase the hypotensive effect of blood pressure-lowering agents
may increase the antiplatelet effect of antiplatelet agents
may have an increased hypotensive effect when combined with antihypertensive agents
may have an increased hypotensive effect when combined with antihypertensive agents
may have an increased hypotensive effect when combined with antihypertensive agents
may have an increased hypotensive effect when combined with antihypertensive agents
may have an increased hypotensive effect when combined with antihypertensive agents
may increase the hypotensive effect of Blood Pressure Lowering Agents
may increase the hypotensive effect of Blood Pressure Lowering Agents
may increase the hypotensive effect of Blood Pressure Lowering Agents
may decrease the hypotensive effect of Blood Pressure Lowering Agents
It may diminish the metabolism when combined with Heparins
It may diminish the metabolism when combined with Heparins
It may diminish the metabolism when combined with Heparins
may have an increasingly adverse effect when combined with prostacyclin analogues
Actions and spectrum:
iloprost is a second-generation structural analog of prostacyclin. It binds prostaglandin EP1 receptors and human prostacyclin.
Frequency defined:
>10%
Cough
Nausea
Jaw pain
Flushing
Hypotension
Headache
1-10%
Syncope
Vomiting
Back pain
Pneumonia
Palpitations
Insomnia
Tongue pain
Muscle cramps
<1%
Bronchospasm
Supraventricular tachycardia
Kidney failure
Black Box Warning
None
Contraindication/Caution:
Contraindication:
Pulmonary edema
Unstable angina
Cerebrovascular events
Pregnancy Warnings:
Pregnancy category: N/A
Lactation: Excretion of the drug into the human breast milk is unknown
Pregnancy categories:
Pharmacology:
iloprost is a vasodilating agent and it belongs to analogue of synthetic prostacyclin.
Pharmacodynamics:
The synthetic prostacyclin PGI2 analog thus iloprost dilates the pulmonary and systemic artery.
Pharmacokinetics:
Limited information is available on ADME.
Administration:
The drug is administered through inhalation with nebulizer.
Patient information leaflet
Generic Name: iloprost
Why do we use iloprost?
It is used in the treatment of pulmonary arterial hypertension.