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Brand Name :
Stromectol
Synonyms :
ivermectin
Class :
Anthelmintics
Brand Name :
Stromectol
Synonyms :
ivermectin
Class :
Anthelmintics
Dosage Forms & Strengths
tablet
3mg
3 mg orally once for 15 to 24 kg
6 mg orally once for 25 to 35 kg
9 mg orally once for 36 to 50 kg
12 mg orally once for 51 to 65 kg
15 mg orally once for 66 to 79 kg
200 mcg/kg orally once for above 80 kg
Demodex folliculorum (Blepharitis) (Off-label)
200 mcg/kg Orally given once in a single dosage, followed by a repeat dosage every one week
Pediculosis capitis (Head Lice) (Off-label)
200 mcg/kg orally given once; may also require 1-2 extra doses repeated after every one week
Due to the Mansonella Streptocera related Filariasis (Off-label)
150 mcg/kg administered as a single dose
Due to the Mansonella Ozzardi-related filariasis (off-label)
6 mg orally administered as a single dose
Gnathostoma Spinigerum a single dosage of 200 mcg/kg
Due to the Sarcoptes Scabiel related Scabies 200 mcg/kg given as a single dosage; may be repeated in 2 weeks if required in Immunocompromised patients
Dosage Forms & Strengths
tablet
3mg
Indicated for intestinal tract strongyloidiasis
:
3 mg orally once for 15 to 24 kg
6 mg orally once for 25 to 35 kg
9 mg orally once for 36 to 50 kg
12 mg orally once for 51 to 65 kg
15 mg orally once for 66 to 79 kg
200 mcg/kg orally once for above 80 kg
Dose Adjustments
Dose considerations In, repeated doses are not necessary; examine the stool to ensure the infection has been eradicated
Refer to the adult dosing regimen
may increase the serum concentration of each other when it is combined
may increase the serum concentration of each other when it is combined
may increase the serum concentration of each other when it is combined
may increase the serum concentration of each other when it is combined
may increase the serum concentration of each other when it is combined
may increase the serum concentration of each other when it is combined
may increase the serum concentration of each other when it is combined
bunazosin (Not available in the United States)
may increase the serum concentration of each other when it is combined
may increase the serum concentration of each other when it is combined
may increase the serum concentration of each other when it is combined
may decrease the therapeutic effect when combined with anti-parkinson agents
may decrease the therapeutic effect when combined with anti-parkinson agents
may decrease the therapeutic effect when combined with anti-parkinson agents
may decrease the therapeutic effect when combined with anti-parkinson agents
may decrease the therapeutic effect when combined with anti-parkinson agents
may enhance the area under the curve when co-administered
may enhance the area under the curve when co-administered
may enhance the area under the curve when co-administered
may enhance the area under the curve when co-administered
may enhance the area under the curve when co-administered
may increase the serum concentration of each other when it is combined
may increase the serum concentration of each other when it is combined
may increase the serum concentration of each other when it is combined
may increase the serum concentration of each other when it is combined
may increase the serum concentration of each other when it is combined
may increase the serum concentration of each other when it is combined
may increase the serum concentration of each other when it is combined
may have an increased anticoagulant effect when combined with vitamin k antagonists
may have an increased anticoagulant effect when combined with vitamin k antagonists
may have an increased anticoagulant effect when combined with vitamin k antagonists
may have an increased anticoagulant effect when combined with vitamin k antagonists
may have an increased anticoagulant effect when combined with vitamin k antagonists
may increase the serum concentration of each other when it is combined
may increase the serum concentration of each other when it is combined
may increase the serum concentration of each other when it is combined
may increase the serum concentration of each other when it is combined
may increase the serum concentration of each other when it is combined
Enhanced bioavailability of ivermectin may result from its conjunction with levamisole
may have an increased risk of rhabdomyolysis & myoglobinuria when combined with ivermectin
anagrelide: they may increase the antiplatelet effect of antiparasitic agents
zanubrutinib: they may increase the antiplatelet effect of antiparasitic agents
Actions and spectrum:
Ivermectin targets various parasites by binding to glutamate-gated chloride ion channels in invertebrate nerve and muscle cells leading to increased permeability and hyperpolarization resulting in parasite paralysis and death.
Frequency not defined
Asthenia
Mild EKG changes
Transient tachycardia
Headache
Insomnia
Vertigo
Rash
Diarrhea
Vomiting
Leukopenia
Limbitis
Tremor
Mild conjunctivitis
Mazzotti reaction
Fever
Ocular damage
Conjunctival hemorrhage
Abdominal pain
Hypotension
Peripheral & facial edema
Dizziness
Hyperthermia
Somnolence
Pruritus
Urticaria
Nausea
Eosinophilia
AST/ALT increased
Myalgia
Blurred vision
Punctate opacity
Edema
Lymphadenopathy
Pruritus rash
Hepatitis
Post marketing Reports
confusion, Neurotoxicity, drowsiness, disorientation, stupor, coma, and death
Black Box Warning:
None
Contraindication/Caution:
Ivermectin is contraindicated for hypersensitivity, co-administration with strong CYP3A4 inhibitors, breastfeeding, and children under 15 kg.
Pregnancy consideration: pregnancy category C
Lactation: It is not known whether ivermectin is excreted in human milk
Pregnancy category:
Pharmacology:
Pharmacodynamics:
ivermectin works by binding to glutamate-gated chloride channels in invertebrate nerve and muscle cells leading to increased permeability of cell membrane to chloride ions, hyperpolarization of the cells, and leading to paralysis and death of parasite. It also has activity against certain viruses but its exact mechanism is not fully understood.
It may modulate the immune response by binding to the host toll-like receptor 7 (TLR7) which is involved in recognition of viral RNA and inhibits the importin alpha/beta-mediated nuclear transport of viral proteins which is necessary for viral replication.
Pharmacokinetics:
Absorption
Rapidly and completely absorbed.
Distribution
Volume of distribution is 50-100 L/kg.
Metabolism
Metabolized by cytochrome P450 enzymes CYP3A4 and CYP2D6.
Elimination and excretion
Half-life is approximately 18 hours.
Administration:
ivermectin given orally or topically depending on the condition being treated.
Patient information leaflet
Generic Name: ivermectin
Pronounced: [ EYE-ver-MEK-tin ]
Why do we use ivermectin?
Ivermectin has broad-spectrum activity and treats parasitic infections, intestinal nematodes, ectoparasites, and filarial worms. Its single dose has more effectiveness which simplifies the treatment when compared to other anthelmintic drugs.
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