Anthropometric Measurements as Predictors of Low Birth Weight Among Tanzanian Neonates: A Hospital-Based Study
November 7, 2025
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Brand Name :
Dicloridrato de manidipino (Brazil), Manivasc (China), manidipine zydus (Greece), manidipine (Italy), Minadil (Thailand), Artedil (Spain)
Synonyms :
manidipine
Class :
Antihypertensive; Calcium Channel Blockers
Dosage Forms & StrengthsÂ
TabletÂ
5mgÂ
10mgÂ
20mgÂ
Initially, 5-10 mg once daily
Increase the dose to 20 mg each based on tolerability and response
No data is availableÂ
Refer to the adult dosingÂ
CYP3A strong enhancers of the small intestine may reduce the bioavailability of manidipine
it increases the effect of hyperkalemia of calcium channel blockers
they increase the effect of neuromuscular blockage of neuromuscular-blocking agents
they increase the effect of neuromuscular blockage of neuromuscular-blocking agents
they increase the effect of neuromuscular blockage of neuromuscular-blocking agents
they increase the effect of neuromuscular blockage of neuromuscular-blocking agents
they increase the effect of neuromuscular blockage of neuromuscular-blocking agents
It may increase the serum concentration when combined with CYP3A4 Inhibitors (Moderate)
It may increase the serum concentration when combined with CYP3A4 Inhibitors (Moderate)
It may increase the serum concentration when combined with CYP3A4 Inhibitors (Moderate)
It may increase the serum concentration when combined with CYP3A4 Inhibitors (Moderate)
It may increase the serum concentration when combined with CYP3A4 Inhibitors (Moderate)
manidipine: they may enhance the serum concentration of CYP3A Inhibitors
manidipine: they may enhance the serum concentration of CYP3A Inhibitors
manidipine: they may enhance the serum concentration of CYP3A Inhibitors
manidipine: they may enhance the serum concentration of CYP3A Inhibitors
manidipine: they may enhance the serum concentration of CYP3A Inhibitors
When acetohexamide is used together with manidipine, this lead to reduction in acetohexamide’s metabolism
CYP3A4 inhibitors increase the concentration of manidipine in serum
may decrease the therapeutic effect when combined with clopidogrel
may enhance the serum concentration when combined with cyclosporine
may have an increased hypotensive effect when combined with calcium channel blockers
may have an increased hypotensive effect when combined with calcium channel blockers
bunazosin (Not available in the United States)
may have an increased hypotensive effect when combined with calcium channel blockers
may have an increased hypotensive effect when combined with calcium channel blockers
may have an increased hypotensive effect when combined with calcium channel blockers
they modify the response of glucose or insulin when taken with manidipine
they modify the response of glucose or insulin when taken with manidipine
they modify the response of glucose or insulin when taken with manidipine
they modify the response of glucose or insulin when taken with manidipine
they modify the response of glucose or insulin when taken with manidipine
Actions and SpectrumÂ
Actions:Â
manidipine exerts its effects by blocking calcium channels in the smooth muscle cells of blood vessels. This action reduces calcium entry into these cells, leading to the relaxation of the blood vessel walls. As a result, blood vessels dilate (widen), which helps to lower blood pressure.Â
Spectrum:Â
manidipine is indicated for treating essential hypertension, which is high blood pressure without a known underlying cause. It can be used as monotherapy (as the sole medication) or in combination with other antihypertensive agents to achieve blood pressure control.Â
Frequency not definedÂ
increased micturition frequencyÂ
lethargyÂ
palpitationsÂ
GI disturbancesÂ
ischaemic chest painÂ
feverÂ
abnormal liver functionÂ
gingival hyperplasiaÂ
eye painÂ
depressionÂ
myocardial ischaemiaÂ
transient blindnessÂ
rashesÂ
myalgiaÂ
impotence.Â
Black Box Warning:Â
NoneÂ
Contraindication/Caution:Â
Contraindications:Â
Cautions:Â
Pregnancy consideration:Â Â
Utilize manidipine with caution during pregnancy.Â
Breastfeeding warnings:Â Â
Utilize manidipine with caution during lactation.Â
Pregnancy category:Â
Category A: Well-controlled and satisfactory studies show no risk to the fetus in the initial or later trimester.Â
<b>Category B: There was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.Â
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.   Â
Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.   Â
Category X: Drugs listed in this category outweigh the risks over benefits. Hence, these categories of drugs need to be avoided by pregnant women.   Â
Category N: No data is available for the drug under this category.Â
Pharmacology:Â Â
manidipine functions as a calcium channel blocker used to treat hypertension. Its primary mechanism involves the inhibition of L-type calcium channels, predominantly located in cardiac and smooth muscle cells. Additionally, it exhibits a degree of selectivity for T-type calcium channels. These channels, involved in regulating neuronal excitability and rhythmic cellular activities, contribute to the overall pharmacological effects of manidipine. By blocking both L-type and, to some extent, T-type calcium channels, the medication induces vasodilation, leading to a reduction in blood pressure.
Pharmacodynamics:Â
manidipine attaches to L- and T-type voltage-dependent calcium channels in smooth muscle cells, forming a stable connection and detaching gradually. This interaction inhibits the influx of extracellular calcium into the cells, preventing muscle contraction. As a result, vasodilation occurs, leading to a reduction in blood pressure.
Pharmacokinetics:Â
AbsorptionÂ
manidipine is administered orally, and its absorption occurs in the gastrointestinal tract. It’s absorbed relatively slowly from the digestive system, contributing to its prolonged action duration.Â
DistributionÂ
Once absorbed, manidipine is distributed throughout the body via the bloodstream. It binds to plasma proteins to varying degrees, affecting its availability for interactions and effects.Â
MetabolismÂ
manidipine is metabolized in the liver through various metabolic pathways, including cytochrome P450 enzymes. The primary metabolite is inactive, and genetic and individual factors might influence the metabolism of manidipine.Â
Elimination and ExcretionÂ
Metabolites resulting from manidipine’s breakdown are primarily excreted in the urine and, minimally in the feces. The elimination half-life of manidipine, which is the time it takes for half of the drug to be cleared from the body, is relatively long.Â
Administration:Â
manidipine is available in tablet form for oral administration. Tablets have various strengths, so your healthcare provider will calculate the appropriate dosage based on your medical condition and individual needs.Â
Patient information leafletÂ
Generic Name: manidipineÂ
Pronounced as: man-i-di-peenÂ
Why do we use manidipine?Â
manidipine belongs to the class of medications known as calcium channel blockers, prescribed for the treatment of high blood pressure (hypertension). Its mechanism of action involves the inhibition of calcium channels in blood vessels.
Hypertension, a significant risk factor for cardiovascular diseases like heart attack, stroke, and kidney failure, can be mitigated by lowering blood pressure. manidipine offers certain advantages over other calcium channel blockers, including a prolonged duration of action, a lower incidence of side effects, and a positive impact on kidney function. Additionally, there is a potential protective effect on blood vessels, preventing them from becoming rigid and thickened.
Despite these benefits, manidipine may lead to some adverse effects, including headaches, dizziness, flushing, ankle swelling, and palpitations. It is essential for individuals taking this medication to be aware of both its advantages and potential side effects, and consultation with a healthcare professional is recommended for a comprehensive understanding of its usage and associated risks.
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