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Brand Name :
Medazin
Synonyms :
medazepam
Class :
Benzodiazepines
Brand Name :
Medazin
Synonyms :
medazepam
Class :
Benzodiazepines
Dosage forms and strengths Â
Oral tablet Â
10 mgÂ
Short course treatment:
Take 10 to 30 mg orally a day with divided doses
In severity of the condition, dosage can be elevated to a maximum of 60 mg in a day
Not indicatedÂ
Refer adult dosingÂ
When acetazolamide is used together with medazepam, the risk or seriousness of CNS depression is enhanced
When amobarbital is used together with medazepam, the risk or seriousness of CNS depression is enhanced
When amoxapine is used together with medazepam, the risk or seriousness of CNS depression is enhanced
When apomorphine is used together with medazepam, the risk or seriousness of CNS depression is enhanced
When atracurium is used together with medazepam, the risk or seriousness of CNS depression is enhanced
When asenapine is used together with medazepam, the risk or seriousness of CNS depression is enhanced
When benperidol is used together with medazepam, the risk or seriousness of CNS depression is enhanced
When benzphetamine is used together with medazepam, the risk or seriousness of CNS depression is enhanced
When brexanolone is used together with medazepam, the risk or seriousness of CNS depression is enhanced
When brexpiprazole is used together with medazepam, the risk or seriousness of CNS depression is enhanced
When brivaracetam is used together with medazepam, the risk or seriousness of CNS depression is enhanced
When bromazepam is used together with medazepam, the risk or seriousness of CNS depression is enhanced
When bromocriptine is used together with medazepam, the risk or seriousness of CNS depression is enhanced
When brompheniramine is used together with medazepam, the risk or seriousness of CNS depression is enhanced
When bupropion is used together with medazepam, the risk or seriousness of CNS depression is enhanced
When buspirone is used together with medazepam, the risk or seriousness of CNS depression is enhanced
When butabarbital is used together with medazepam, the risk or seriousness of CNS depression is enhanced
When butalbital is used together with medazepam, the risk or seriousness of CNS depression is enhanced
When butriptyline is used together with medazepam, the risk or seriousness of CNS depression is enhanced
When cabergoline is used together with medazepam, the risk or seriousness of CNS depression is enhanced
When cariprazine is used together with medazepam, the risk or seriousness of CNS depression is enhanced
When cetirizine is used together with medazepam, the risk or seriousness of CNS depression is enhanced
When chlorpromazine is used together with medazepam, the risk or seriousness of CNS depression is enhanced
When cisapride is used together with medazepam, the risk or seriousness of CNS depression is enhanced
When clemastine is used together with medazepam, the risk or seriousness of CNS depression is enhanced
When clomipramine is used together with medazepam, the risk or seriousness of CNS depression is enhanced
When clonazepam is used together with medazepam, the risk or seriousness of CNS depression is enhanced
When clotiazepam is used together with medazepam, the risk or seriousness of CNS depression is enhanced
When cyclizine is used together with medazepam, the risk or seriousness of CNS depression is enhanced
When dantrolene is used together with medazepam, the risk or seriousness of CNS depression is enhanced
When desflurane is used together with medazepam, the risk or seriousness of CNS depression is enhanced
When desipramine is used together with medazepam, the risk or seriousness of CNS depression is enhanced
When dexbrompheniramine is used together with medazepam, the risk or seriousness of CNS depression is enhanced
When dextromethorphan is used together with medazepam, the risk or seriousness of CNS depression is enhanced
When diazepam is used together with medazepam, the risk or seriousness of CNS depression is enhanced
When dihydroergotamine is used together with medazepam, the risk or seriousness of CNS depression is enhanced
When donepezil is used together with medazepam, the risk or seriousness of CNS depression is enhanced
When doxepin is used together with medazepam, the risk or seriousness of CNS depression is enhanced
When ergometrine is used together with medazepam, the risk or seriousness of CNS depression is enhanced
When estazolam is used together with medazepam, the risk or seriousness of CNS depression is enhanced
When ethosuximide is used together with medazepam, the risk or seriousness of CNS depression is enhanced
When felbamate is used together with medazepam, the risk or seriousness of CNS depression is enhanced
When flibanserin is used together with medazepam, the risk or seriousness of CNS depression is enhanced
When flunarizine is used together with medazepam, the risk or seriousness of CNS depression is enhanced
When flurazepam is used together with medazepam, the risk or seriousness of CNS depression is enhanced
When gabapentin is used together with medazepam, the risk or seriousness of CNS depression is enhanced
When acetophenazine is used together with medazepam, the risk or seriousness of CNS depression is enhanced
When agomelatine is used together with medazepam, the risk or seriousness of CNS depression is enhanced
When alimemazine is used together with medazepam, the risk or seriousness of CNS depression is enhanced
When almotriptan is used together with medazepam, the risk or seriousness of CNS depression is enhanced
When alosetron is used together with medazepam, the risk or seriousness of CNS depression is enhanced
When alprazolam is used together with medazepam, the risk or seriousness of CNS depression is enhanced
When amisulpride is used together with medazepam, the risk or seriousness of CNS depression is enhanced
When amitriptyline is used together with medazepam, the risk or seriousness of CNS depression is enhanced
Actions and Spectrum:Â
Action:Â
Anxiolytic: medazepam acts on the central nervous system by enhancing the inhibitory effects of GABA, a neurotransmitter that reduces brain activity. This results in a calming effect and a reduction in anxiety and apprehension.Â
Sedative: medazepam has a sedative effect, making it useful in treating anxiety-related sleep disturbances or insomnia. It can help induce and maintain sleep.Â
Spectrum:Â Â
Anxiety Disorders: It is prescribed for treating generalized anxiety disorder (GAD) and other anxiety-related disorders.Â
Insomnia: medazepam can treat sleep disturbances associated with anxiety or other conditions.Â
Frequency not defined Â
decreased libidoÂ
depressionÂ
bradycardiaÂ
hypotensionÂ
chest painÂ
coordination disordersÂ
dizzinessÂ
drowsinessÂ
FatigueÂ
Black Box Warning:Â Â
None
Contraindication/Caution:Â Â
Acute Narrow-Angle Glaucoma: Benzodiazepines like medazepam can increase intraocular pressure, so they should be avoided in individuals with acute narrow-angle glaucoma.Â
Pregnancy and Breastfeeding: medazepam is generally not recommended during pregnancy, especially during the first trimester, and should be avoided during breastfeeding.Â
History of Substance Abuse: People who have a prior history of substance abuse or addiction may face an increased susceptibility to developing a dependency on medazepam. Consequently, they should exercise caution when using it or consider refraining from its use entirely.Â
Pregnancy warnings:    Â
Pregnancy category: N/AÂ
Lactation: Excreted into human milk is unknownÂ
Pregnancy Categories:        Â
Category A: Studies that were well-controlled and met expectations revealed no risk to the fetus in either the first or second trimester.Â
<b>Category B: There were a lack of studies on pregnant women and no evidence of risk to the fetus in animal experiments.  Â
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.   Â
Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.  Â
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.   Â
Category N: There is no data available for the drug under this category
Pharmacology: Â
medazepam is a medication that belongs to the benzodiazepine class of drugsÂ
Pharmacodynamics:Â Â
medazepam, like other benzodiazepines, acts on the CNS by enhancing the effects of GABA. This binding increases the inhibitory activity of GABA, resulting in a decrease in neural excitability and inducing a soothing influence on the brain.Â
Pharmacokinetics:Â
AbsorptionÂ
medazepam is well-absorbed when taken orally, and its onset of action is relatively rapid.Â
DistributionÂ
It is distributed throughout the body, with the brain and other tissues with high lipid contents having the high concentration.Â
MetabolismÂ
medazepam is metabolized in the liver to its active metabolite, nordazepam. nordazepam has a longer half-life than medazepam and contributes to pharmacological effects.Â
Excretion and Elimination Â
The primary route of excretion for the drug and its metabolites is through the urinary system.Â
The elimination half-life of medazepam varies but is typically around 30 hours.Â
Administration: Â
The administration is by oral route.Â
Patient information leafletÂ
Generic Name: medazepamÂ
Why do we use medazepam? Â
Anxiety Disorders: medazepam is prescribed to treat various anxiety disorder. It helps reduce excessive anxiety and nervousness.Â
Insomnia: This medication can treat insomnia, mainly when anxiety or stress is a contributing factor. medazepam helps induce sleep and improve sleep quality.Â
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