Gepotidacin Gains FDA Priority Review for Breakthrough Oral Gonorrhea Therapy
December 13, 2025
Free CME credits
Both our subscription plans include Free CME/CPD AMA PRA Category 1 credits.
Brand Name :
Nopron
Synonyms :
niaprazine
Class :
Hypnotics & sedatives
Brand Name :
Nopron
Synonyms :
niaprazine
Class :
Hypnotics & sedatives
Adult Dosing
Not indicated
Refer adult dosing
When acetazolamide is used together with niaprazine, the risk or seriousness of CNS depression is enhanced
When amisulpride is used together with niaprazine, the risk or seriousness of CNS depression is enhanced
When amitriptyline is used together with niaprazine, the risk or seriousness of CNS depression is enhanced
When amobarbital is used together with niaprazine, the risk or seriousness of CNS depression is enhanced
When amoxapine is used together with niaprazine, the risk or seriousness of CNS depression is enhanced
When apomorphine is used together with niaprazine, the risk or seriousness of CNS depression is enhanced
When articaine is used together with niaprazine, the risk or seriousness of CNS depression is enhanced
When asenapine is used together with niaprazine, the risk or seriousness of CNS depression is enhanced
When atracurium is used together with niaprazine, the risk or seriousness of CNS depression is enhanced
When benperidol is used together with niaprazine, the risk or seriousness of CNS depression is enhanced
When benzocaine is used together with niaprazine, the risk or seriousness of CNS depression is enhanced
When benzphetamine is used together with niaprazine, the risk or seriousness of CNS depression is enhanced
When brexanolone is used together with niaprazine, the risk or seriousness of CNS depression is enhanced
When brivaracetam is used together with niaprazine, the risk or seriousness of CNS depression is enhanced
When bromazepam is used together with niaprazine, the risk or seriousness of CNS depression is enhanced
When bromocriptine is used together with niaprazine, the risk or seriousness of CNS depression is enhanced
When brompheniramine is used together with niaprazine, the risk or seriousness of CNS depression is enhanced
When bupivacaine is used together with niaprazine, the risk or seriousness of CNS depression is enhanced
When bupropion is used together with niaprazine, the risk or seriousness of CNS depression is enhanced
When buspirone is used together with niaprazine, the risk or seriousness of CNS depression is enhanced
When butabarbital is used together with niaprazine, the risk or seriousness of CNS depression is enhanced
When butalbital is used together with niaprazine, the risk or seriousness of CNS depression is enhanced
When butriptyline is used together with niaprazine, the risk or seriousness of CNS depression is enhanced
When cabergoline is used together with niaprazine, the risk or seriousness of CNS depression is enhanced
When carbamazepine is used together with niaprazine, the risk or seriousness of CNS depression is enhanced
When cetirizine is used together with niaprazine, the risk or seriousness of CNS depression is enhanced
When chloroprocaine is used together with niaprazine, the risk or seriousness of CNS depression is enhanced
When chlorpheniramine is used together with niaprazine, the risk or seriousness of CNS depression is enhanced
When cisapride is used together with niaprazine, the risk or seriousness of CNS depression is enhanced
When clomipramine is used together with niaprazine, the risk or seriousness of CNS depression is enhanced
When clonazepam is used together with niaprazine, the risk or seriousness of CNS depression is enhanced
When clozapine is used together with niaprazine, the risk or seriousness of CNS depression is enhanced
When cyclizine is used together with niaprazine, the risk or seriousness of CNS depression is enhanced
When dantrolene is used together with niaprazine, the risk or seriousness of CNS depression is enhanced
When desflurane is used together with niaprazine, the risk or seriousness of CNS depression is enhanced
When desipramine is used together with niaprazine, the risk or seriousness of CNS depression is enhanced
When dexbrompheniramine is used together with niaprazine, the risk or seriousness of CNS depression is enhanced
When dextromethorphan is used together with niaprazine, the risk or seriousness of CNS depression is enhanced
When diazepam is used together with niaprazine, the risk or seriousness of CNS depression is enhanced
When dihydroergotamine is used together with niaprazine, the risk or seriousness of CNS depression is enhanced
When dolasetron is used together with niaprazine, the risk or seriousness of CNS depression is enhanced
When donepezil is used together with niaprazine, the risk or seriousness of CNS depression is enhanced
When dosulepin is used together with niaprazine, the risk or seriousness of CNS depression is enhanced
When doxepin is used together with niaprazine, the risk or seriousness of CNS depression is enhanced
When dyclonine is used together with niaprazine, the risk or seriousness of CNS depression is enhanced
When estazolam is used together with niaprazine, the risk or seriousness of CNS depression is enhanced
When ethosuximide is used together with niaprazine, the risk or seriousness of CNS depression is enhanced
When ethotoin is used together with niaprazine, the risk or seriousness of CNS depression is enhanced
When felbamate is used together with niaprazine, the risk or seriousness of CNS depression is enhanced
When fenfluramine is used together with niaprazine, the risk or seriousness of CNS depression is enhanced
When fentanyl is used together with niaprazine, the risk or seriousness of CNS depression is enhanced
When flunarizine is used together with niaprazine, the risk or seriousness of CNS depression is enhanced
When flurazepam is used together with niaprazine, the risk or seriousness of CNS depression is enhanced
When fosphenytoin is used together with niaprazine, the risk or seriousness of CNS depression is enhanced
When gabapentin is used together with niaprazine, the risk or seriousness of CNS depression is enhanced
When halazepam is used together with niaprazine, the risk or seriousness of CNS depression is enhanced
When haloperidol is used together with niaprazine, the risk or seriousness of CNS depression is enhanced
When halothane is used together with niaprazine, the risk or seriousness of CNS depression is enhanced
When imipramine is used together with niaprazine, the risk or seriousness of CNS depression is enhanced
When ketamine is used together with niaprazine, the risk or seriousness of CNS depression is enhanced
When ketazolam is used together with niaprazine, the risk or seriousness of CNS depression is enhanced
When lamotrigine is used together with niaprazine, the risk or seriousness of CNS depression is enhanced
When levobupivacaine is used together with niaprazine, the risk or seriousness of CNS depression is enhanced
When levocetirizine is used together with niaprazine, the risk or seriousness of CNS depression is enhanced
when lorazepam is used together with niaprazine, the risk or seriousness of CNS depression is enhanced
when acetophenazine is used together with niaprazine, the risk or seriousness of CNS depression is enhanced
when alfentanil is used together with niaprazine, the risk or seriousness of CNS depression is enhanced
when agomelatine is used together with niaprazine, the risk or seriousness of CNS depression is enhanced
when alimemazine is used together with niaprazine, the risk or seriousness of CNS depression is enhanced
when almotriptan is used together with niaprazine, the risk or seriousness of CNS depression is enhanced
when alosetron is used together with niaprazine, the risk or seriousness of CNS depression is enhanced
when alprazolam is used together with niaprazine, the risk or seriousness of CNS depression is enhanced
Actions and Spectrum:
Action:
Sedative-Hypnotic: niaprazine exerts its primary action as a sedative-hypnotic agent. This means it can induce sleep and reduce anxiety or agitation.
Spectrum:
Insomnia: niaprazine is primarily prescribed for treating insomnia, characterized by difficulty falling or staying asleep. It can help individuals with insomnia by promoting relaxation and sleepiness, allowing them to fall asleep more efficiently and improve their overall sleep quality and duration.
Hypersensitivity
visual disturbances
glaucoma
urinary retention
dry mouth
Drowsiness
Black Box Warning:
None
Contraindication/Caution:
Hypersensitivity: Individuals with a known hypersensitivity or allergy to niaprazine or any of its components should avoid its use.
Severe Respiratory Disorders: niaprazine can depress the central nervous system, including the respiratory centers. Therefore, it should be avoided in individuals with severe respiratory disorders, such as severe chronic obstructive pulmonary disease (COPD) or sleep apnea, as it may worsen these conditions.
Pregnancy and Breastfeeding: The safety of niaprazine during pregnancy and breastfeeding has not been well-established. It is advisable to utilize it exclusively during these times when the potential advantages surpass the potential risks, and with the supervision of a medical expert.
Children and Elderly: niaprazine may not be suitable for very young children or older people, as they can be more sensitive to its effects and may increase the risk of falls or other adverse events.
Pregnancy warnings:
Pregnancy category: N/A
Lactation: Excreted into human milk is unknown
Pregnancy Categories:
Category A: Studies that were well-controlled and met expectations revealed no risk to the fetus in either the first or second trimester.
Category B: There were a lack of studies on pregnant women and no evidence of risk to the fetus in animal experiments.
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.
Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.
Category N: There is no data available for the drug under this category
Pharmacology:
niaprazine is primarily indicated for its sedative and anxiolytic (anxiety-reducing) properties.
Pharmacodynamics:
niaprazine is thought to exert its pharmacological effects through interactions with the central nervous system.
It primarily acts as a non-specific depressant of the CNS, which means it can cause sedation and reduce anxiety by slowing down brain activity.
Pharmacokinetics:
Absorption
niaprazine is typically administered orally and is absorbed through the gastrointestinal tract.
Distribution
It can distribute throughout the body, including the brain, due to its lipophilic properties.
Metabolism
niaprazine is metabolized in the liver, but specific details about its metabolic pathways may not be well-documented.
Excretion and Elimination
The elimination half-life of niaprazine may vary from person to person, but it is generally relatively short.
Administration:
The route of administration is oral.
The timing of niaprazine administration can vary.
It is often taken at bedtime.
Patient information leaflet
Generic Name: niaprazine
Why do we use niaprazine?
Insomnia: niaprazine has been primarily prescribed as a sedative-hypnotic agent to treat insomnia.
Anxiety: In some cases, niaprazine has been used to alleviate symptoms of anxiety and restlessness. Its sedative properties can help calm nerves and promote relaxation.
Premedication: niaprazine may be administered as a premedication before surgical procedures to reduce anxiety and induce drowsiness in patients.
Motion Sickness: There have been reports of niaprazine being used to alleviate symptoms of motion sickness, such as nausea and vomiting. It can help individuals tolerate travel by car, plane, or boat more comfortably.
Both our subscription plans include Free CME/CPD AMA PRA Category 1 credits.
On course completion, you will receive a full-sized presentation quality digital certificate.
A dynamic medical simulation platform designed to train healthcare professionals and students to effectively run code situations through an immersive hands-on experience in a live, interactive 3D environment.
When you have your licenses, certificates and CMEs in one place, it's easier to track your career growth. You can easily share these with hospitals as well, using your medtigo app.
