Performance Comparison of Microfluidic and Immunomagnetic Platforms for Pancreatic CTC Enrichment
November 15, 2025
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Brand Name :
Bicillin LA
(United States) [Available] ,Extencilline
(United States) [Available] ,Lentocilin
(United States) [Pending for FDA approval]Synonyms :
Benzylpenicillin, Benzyl benicillin, Penicillin G, Benzylpenicillinic acid, and Benzylpenicillinum
Class :
Antimicrobials and Antiviral drugs; Penicillins
Brand Name :
Bicillin LA
(United States) [Available] ,Extencilline
(United States) [Available] ,Lentocilin
(United States) [Pending for FDA approval]Synonyms :
Benzylpenicillin, Benzyl benicillin, Penicillin G, Benzylpenicillinic acid, and Benzylpenicillinum
Class :
Antimicrobials and Antiviral drugs; Penicillins
Dosage forms and strengths
Injectable suspension
600000 units per 1mlÂ
1.2 million units per 2mlÂ
2.4 million units per 4mlÂ
Group A Streptococcal (GAS) InfectionsÂ
1.2 million units given IM daily as a single dose
Upper Respiratory Tract ConditionsÂ
1.2 million units given IM per day as a single dose
1.2 million units given IM once a month or 600000 units given IM for every 2 weeks.Â
Indicated for Neurosyphilis:
US CDC recommends for bicillin a dose of 2.4 million units given IM once a week for 3 doses
US CDC recommends for permapen a dose of 3 million units given IM once a week for 2-3 doses
Indicated for Syphilis (early/late):
2.4 million units given IM per day as a single dose
Dosage forms and strengths
Injectable suspension
600000 units per 1mlÂ
1.2 million units per 2mlÂ
2.4 million units per 4mlÂ
Group A Streptococcal (GAS) InfectionsÂ
wt <27 kg: 600,000 U IM daily
wt > 27 kg: 1.2 million U IM daily
When penicillin G benzathine combines with bcg vaccine, the antitumor activity of vaccine decreases.
When penicillin G benzathine combines with cholera vaccine, the activity and effectiveness of the vaccine decreases.
When penicillin G benzathine combines with methotrexate, the methotrexate effectiveness and blood levels increase.
When penicillin G benzathine combines with typhoid vaccine, the activity and effectiveness of the vaccine decreases.
when both drugs are combined, there may be a reduced effect of penicillin g benzathine  
When penicillin G benzathine combines with anisindione, the increased risk of bleeding is seen in renal or liver impairment and elderly patients.
When penicillin G benzathine combines with chloramphenicol, the action and effectiveness of penicillin G benzathine decreases.
When penicillin G benzathine combines with demeclocycline, the action and effectiveness of penicillin G benzathine decreases.
When penicillin G benzathine combines with dicumarol, the increased risk of bleeding is seen in renal or liver impairment and elderly patients.
When penicillin G benzathine combines with doxycycline, the action and effectiveness of penicillin G benzathine decreases.
When penicillin G benzathine combines with entecavir, both drugs may increase the blood levels.
When penicillin G benzathine combines with estradiol, the effect and activity of estradiol decreases.
When penicillin G benzathine combines with ethinyl estradiol, the effect and activity of ethinyl estradiol decreases.
When penicillin G benzathine combines with minocycline, the action and effectiveness of penicillin G benzathine decreases.
When penicillin G benzathine combines with mycophenolic acid, the mycophenolic acid effectiveness and blood levels decreases.
When penicillin G benzathine combines with pemetrexed, the pemetrexed effectiveness and blood levels increase.
When penicillin G benzathine combines with tetracycline, the action and effectiveness of penicillin G benzathine decreases.
When penicillin G benzathine combines with warfarin, the increased risk of bleeding is seen in renal or liver impairment and elderly patients.
bismuth subcitrate, metronidazole and tetracycline
The interaction may depress the therapeutic efficacy of tetracyclines
The interaction may depress the therapeutic efficacy of tetracyclines
The interaction may depress the therapeutic efficacy of tetracyclines
The interaction may depress the therapeutic efficacy of tetracyclines
The interaction may depress the therapeutic efficacy of tetracyclines
penicillins may decrease the serum concentration of Aminoglycosides
penicillins may decrease the serum concentration of Aminoglycosides
penicillins may decrease the serum concentration of Aminoglycosides
penicillins may decrease the serum concentration of Aminoglycosides
penicillins may decrease the serum concentration of Aminoglycosides
may increase the anticoagulant effect
may increase the anticoagulant effect
may increase the anticoagulant effect
may increase the anticoagulant effect
may increase the anticoagulant effect
Penicillins: they may diminish the serum concentration of aminoglycosides
neomycin/polymyxin B/bacitracin topical
Penicillins: they may diminish the serum concentration of aminoglycosides
Penicillins: they may diminish the serum concentration of aminoglycosides
Penicillins: they may diminish the serum concentration of aminoglycosides
Penicillins: they may diminish the serum concentration of aminoglycosides
penicillins may enhance the hypokalemic effect of dichlorphenamide
acemetacin may increase the serum concentration of penicillins
bismuth subcitrate, metronidazole and tetracycline
tetracyclines may diminish the therapeutic effect of penicillins
tetracyclines may diminish the therapeutic effect of penicillins
tetracyclines may diminish the therapeutic effect of penicillins
tetracyclines may diminish the therapeutic effect of penicillins
tetracyclines may diminish the therapeutic effect of penicillins
penicillins may iincrease the anticoagulant effect of Vitamin K Antagonists
probenecid may increase the serum concentration of penicillins
penicillins may decrease serum concentrations of the active metabolite(s) of mycophenolate
bismuth subcitrate, metronidazole and tetracycline
may reduce the therapeutic effect of penicillins
may reduce the therapeutic effect of penicillins
may reduce the therapeutic effect of penicillins
may reduce the therapeutic effect of penicillins
may reduce the therapeutic effect of penicillins
acemetacin: they may enhance the serum concentration of penicillins
dichlorphenamide: they may increase the hypokalemic effect of penicillins
Could potentially reduce concentration serum for the active metabolite(s) of mycophenolate
may decrease the therapeutic effect when combined with penicillins
The drug effectiveness of both may be decreased by synergism/antagonism.
The drug effectiveness of both may be decreased by synergism/antagonism.
The drug effectiveness of both may be decreased by synergism/antagonism.
The increase plasma levels, and half-life of penicillin increases by inhibiting renal tubular secretion.
The drug effectiveness of both may be decreased by synergism/antagonism.
Penicillin G benzathine is a long-acting antibiotic that is used to treat bacterial infections. It is a form of penicillin, which is a type of antibiotic that works by inhibiting the synthesis of the bacterial cell wall.
The action of penicillin G benzathine is to kill or inhibit the growth of bacteria. It is effective against a wide range of bacteria, including those that cause infections such as pneumonia, strep throat, and gonorrhea.
The spectrum of activity for penicillin G benzathine is broad, meaning that it is effective against a wide range of bacteria. It is particularly effective against gram-positive bacteria, which are bacteria that have a thick peptidoglycan layer in their cell walls. Some examples of gram-positive bacteria that are susceptible to penicillin G benzathine include Staphylococcus aureus, Streptococcus pneumoniae, and Streptococcus pyogenes. Penicillin G benzathine is also effective against some gram-negative bacteria, such as Neisseria gonorrhoeae, which causes gonorrhea.
Overall, penicillin G benzathine is an effective antibiotic that is used to treat a variety of bacterial infections. It is well tolerated by most people and has a low risk of side effects.
Frequency not definedÂ
AgitationÂ
AnxietyÂ
Bleeding gumsÂ
BloatingÂ
Bloody/cloudy urineÂ
Blurred visionÂ
ConfusionÂ
CoughÂ
Dark urineÂ
DiarrheaÂ
Difficult or painful urinationÂ
Difficulty breathingÂ
Difficulty swallowingÂ
Dizziness Â
Hearing lossÂ
Increased thirstÂ
NauseaÂ
NosebleedsÂ
Painful or difficult urinationÂ
RigidityÂ
SeizuresÂ
TremorsÂ
VomitingÂ
Weight gainÂ
Yellowing of the eyes or skinÂ
The black box warning for penicillin G benzathine states that the drug should be used with caution in patients who have a history of hypersensitivity to penicillins or cephalosporins, as they may be at increased risk for an allergic reaction to the medication.
Contraindication / Caution:
Pregnancy and lactation:Â
Pregnancy:
AU TGA shows penicillin G benzathine to fall in pregnancy category AÂ
In pregnant women the risk of malformation with the use of penicillin G benzathine is unlikely.Â
Lactation:Â
There is no evidence of adverse effects on fetus with the use of penicillin G benzathine.Â
Pregnancy Categories:Â
Lactation:Â
Pharmacology:
penicillin G benzathine is an antibiotic that belongs to the penicillin class of drugs. It is used to treat a wide range of bacterial infections, including skin infections, respiratory tract infections, and sexually transmitted infections.
penicillin G benzathine is a long-acting formulation of penicillin that is administered by injection. It is slowly absorbed from the injection site and then slowly released into the bloodstream, providing sustained levels of the drug over a period of several weeks. This allows for less frequent dosing compared to other forms of penicillin.
Pharmacodynamics:
The mechanism of action of penicillin G benzathine is similar to other penicillins. It works by inhibiting the synthesis of the bacterial cell wall, which is essential for the survival and growth of bacteria. By disrupting the cell wall, penicillin G benzathine can kill the bacteria or prevent their growth and reproduction.
Administration:
penicillin G benzathine is a long-acting form of penicillin that is administered by injection.
It is typically given in a single dose and is used to treat infections caused by bacteria.
It is important to follow the instructions of a healthcare provider when administering this medication, including proper handling and disposal of needles and syringes.
Generic name: penicillin G benzathine
Pronunciation:Â PEN-i-SIL-in G BEN-za-theen
Why do we use penicillin G benzathine?Â
penicillin G benzathine is used for treating various bacterial infections, particularly those caused by streptococcal bacteria. It’s a long-acting form of penicillin that is administered through an intramuscular injection. This medication is often used for the treatment of infections such as syphilis, rheumatic fever, and certain types of skin and soft tissue infections.
The choice to use penicillin G benzathine is usually based on its extended duration of action, which allows for less frequent dosing compared to other forms of penicillin. This can be particularly beneficial for patients who may have difficulty adhering to a strict dosing schedule. The drug’s long-lasting effect helps maintain effective levels of the antibiotic in the bloodstream over an extended period, ensuring continuous treatment of the infection.
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