Long COVID Patterns in the RECOVER-Adult Study
November 21, 2025
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Brand Name :
Biltricide
Synonyms :
praziquantel
Class :
Anthelmintics
Brand Name :
Biltricide
Synonyms :
praziquantel
Class :
Anthelmintics
Dosage forms & StrengthsÂ
TabletÂ
600mgÂ
Dosage forms & StrengthsÂ
TabletÂ
600mgÂ
Refer to adult dosing.Â
praziquantel: they may diminish the serum concentration of CYP3A4 Inducers
praziquantel: they may diminish the serum concentration of CYP3A4 Inducers
praziquantel: they may diminish the serum concentration of CYP3A4 Inducers
praziquantel: they may diminish the serum concentration of CYP3A4 Inducers
praziquantel: they may diminish the serum concentration of CYP3A4 Inducers
may increase the serum concentration of each other when it is combined
may increase the serum concentration of each other when it is combined
may increase the serum concentration of each other when it is combined
may increase the serum concentration of each other when it is combined
may increase the serum concentration of each other when it is combined
may increase the serum concentration of each other when it is combined
may increase the serum concentration of each other when it is combined
bunazosin (Not available in the United States)
may increase the serum concentration of each other when it is combined
may increase the serum concentration of each other when it is combined
may increase the serum concentration of each other when it is combined
When nafcillin combines with praziquantel, nafcillin will decrease the effect of action of praziquantel by affecting enzyme CYP3A4 metabolism.
may decrease the therapeutic effect when combined with anti-parkinson agents
may decrease the therapeutic effect when combined with anti-parkinson agents
may decrease the therapeutic effect when combined with anti-parkinson agents
may decrease the therapeutic effect when combined with anti-parkinson agents
may decrease the therapeutic effect when combined with anti-parkinson agents
may enhance the area under the curve when co-administered
may enhance the area under the curve when co-administered
may enhance the area under the curve when co-administered
may enhance the area under the curve when co-administered
may enhance the area under the curve when co-administered
may increase the serum concentration of each other when it is combined
may increase the serum concentration of each other when it is combined
may increase the serum concentration of each other when it is combined
may increase the serum concentration of each other when it is combined
may increase the serum concentration of each other when it is combined
may increase the serum concentration of each other when it is combined
may increase the serum concentration of each other when it is combined
CYP3A strong enhancers of the small intestine may reduce the bioavailability of praziquantel 
when bromazepam and praziquantel are used together, there is a potential reduction in the bromazepam's metabolism
may increase the serum concentration of each other when it is combined
may increase the serum concentration of each other when it is combined
may increase the serum concentration of each other when it is combined
may increase the serum concentration of each other when it is combined
may increase the serum concentration of each other when it is combined
It may enhance levels when combined with albendazole by unspecified interactions mechanism
anagrelide: they may increase the antiplatelet effect of antiparasitic agents
zanubrutinib: they may increase the antiplatelet effect of antiparasitic agents
Actions and Spectrum:Â
The action of praziquantel is not completely understood, but it is believed to work by increasing the permeability of the cell membrane of the parasites, causing muscle contraction and paralysis, leading to their death.Â
praziquantel has a broad spectrum of activity against various species of parasites, including Schistosoma mansoni, Schistosoma haematobium, Schistosoma japonicum, Fasciola hepatica, and various tapeworms such as Taenia saginata, Taenia solium, and Diphyllobothrium latum.Â
Frequency definedÂ
1-10%Â
DizzinessÂ
HeadacheÂ
Appetite lossÂ
CSF reaction syndromeÂ
DiaphoresisÂ
DrowsinessÂ
Abdominal painÂ
NauseaÂ
VomitingÂ
<1%Â
UrticariaÂ
RashÂ
DiarrheaÂ
ItchingÂ
FeverÂ
Contraindication/Caution:Â
ContraindicationÂ
praziquantel is contraindicated in patients with known hypersensitivity to the drug or any of its components.Â
Other contraindications of praziquantel include:Â
CautionÂ
Pregnancy consideration:Â Â
AU TGA pregnancy category: B1
US FDA pregnancy category: Not assigned.Â
Excreted into human milk: Yes (small amounts)Â
Pregnancy category:Â
Pharmacology:Â
praziquantel is an anthelmintic medication that exerts its pharmacological effects by altering the permeability of the cell membrane of the parasites, leading to muscle contraction, paralysis, and death of the parasite.Â
The exact mechanism of action of praziquantel is not completely understood, but it is believed to involve interactions with calcium channels in the parasite’s membrane.
praziquantel enhances the influx of calcium ions into the parasite, leading to increased muscle contraction and disruption of the cell membrane, which ultimately leads to the parasite’s death.Â
Pharmacodynamics:Â
Mechanism of action: This medication works by increasing the cell membrane permeability to calcium in schistosomes, which are parasitic worms. This, in turn, leads to the paralysis of worm musculature and causes the worm to dislodge from its position.Â
Pharmacokinetics:Â
AbsorptionÂ
praziquantel is absorbed at a rate of approximately 80% when taken orally. The peak plasma time for this medication is between 1-3 hours.Â
DistributionÂ
The concentration of this medication in cerebrospinal fluid (CSF) is approximately 14-20% of the concentration found in plasma. It is also protein-bound at a rate of approximately 80%.Â
MetabolismÂ
This medication undergoes extensive first-pass metabolism, which means that a significant portion of the drug is metabolized by the liver before it reaches systemic circulation. Â
The half-life of the parent drug is between 0.8-1.5 hrs, while the half-life of its metabolites is approximately 4.5 hrs.Â
Elimination and ExcretionÂ
This medication is primarily excreted in urine, with approximately 99% of the drug excreted in the form of its metabolites.Â
Administration:Â
Oral administrationÂ
praziquantel is typically administered orally, with or without food, depending on the patient’s preference. The dosage of praziquantel depends on the type of infection being treated and the patient’s weight. Â
It is key to follow the prescribed dosage and duration of treatment as directed by a healthcare professional, even if symptoms improve before the end of the treatment course.Â
If a dose of praziquantel is missed, it should be taken as soon as possible, unless it is near to the time for next dose. In that case, the missed dose should be skipped, and the regular dosing schedule should be resumed.Â
Patient information leafletÂ
Generic Name: praziquantelÂ
Pronounced: [ PRAZ-i-KWON-tel ]Â
Why do we use praziquantel?Â
praziquantel is an anthelmintic medication used to treat several types of parasitic infections. Some of the common uses of praziquantel include:Â
Â
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