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Brand Name :
Malaridine
Synonyms :
pyronaridine
Class :
Antimalarial drug
Dosage Forms & Strengths
Tablet
100 mg
Take a dose of 1200 mg orally divided into four doses for three days
Two doses given on the initial day at 4 to 6 hours intervals followed by a single dose daily for the next two days
Not determined
Refer to adult dosing
may enhance the area under the curve when co-administered
may enhance the area under the curve when co-administered
may enhance the area under the curve when co-administered
may enhance the area under the curve when co-administered
may enhance the toxic effect of each other when combined
may enhance the area under the curve when co-administered
May increase the QTc-prolonging effect of each other when combined
May increase the QTc-prolonging effect of each other when combined
May increase the QTc-prolonging effect of each other when combined
May increase the QTc-prolonging effect of each other when combined
May increase the QTc-prolonging effect of each other when combined
may increase the hypoglycemic effect of Agents with each other when combined
may increase the hypoglycemic effect of Agents with each other when combined
may increase the hypoglycemic effect of Agents with each other when combined
may increase the hypoglycemic effect of Agents with each other when combined
may increase the hypoglycemic effect of Agents with each other when combined
may enhance the toxic effect of each other when combined
may enhance the toxic effect of each other when combined
may enhance the toxic effect of each other when combined
may enhance the toxic effect of each other when combined
may enhance the toxic effect of each other when combined
pyronaridine: it may increase the risk of methemoglobinemia associated agents
pyronaridine: it may increase the risk of methemoglobinemia associated agents
pyronaridine: it may increase the risk of methemoglobinemia associated agents
pyronaridine: it may increase the risk of methemoglobinemia associated agents
pyronaridine: it may increase the risk of methemoglobinemia associated agents
Actions and Spectrum
pyronaridine is an antimalarial drug that primarily works by inhibiting the growth and replication of the malaria parasite within red blood cells. pyronaridine has a broad spectrum of activity against different species of malaria parasites. It is effective against both Plasmodium falciparum and Plasmodium vivax, which are the most common species responsible for malaria infections.
Frequency not defined
None
Black Box Warning
None
Contraindication/Caution:
Contraindication:
Caution:
Pregnancy consideration:
Pregnancy category: N/A
Lactation: Excretion into human milk is unknown
Pregnancy Categories:
Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester.
Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.
Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.
Category N: There is no data available for the drug under this category.
Pharmacology
pyronaridine primarily exerts its antimalarial activity by inhibiting the growth and replication of the malaria parasite within red blood cells. It interferes with the parasite’s ability to metabolize hemoglobin, a crucial nutrient source for the parasite.
Pharmacodynamics
pyronaridine may interfere with the parasite’s ability to break down hemoglobin into amino acids. This disruption of the parasite’s digestive processes can limit its access to essential nutrients, hindering its growth and replication.
Pharmacokinetics
Absorption
pyronaridine is absorbed into the bloodstream after oral intake.
Distribution
pyronaridine is distributed throughout the body.
Metabolism
pyronaridine undergoes extensive metabolism in the liver.
Elimination and excretion
pyronaridine excreted through the bile into the feces.
Administration
pyronaridine is taken orally in the form of tablets.
Patient information leaflet
Generic Name: pyronaridine
Why do we use pyronaridine?
pyronaridine is used as a treatment for malaria.
It is used in combination with other antimalarial drugs to enhance its effectiveness and reduce the risk of drug resistance.
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