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Brand Name :
Neut
Synonyms :
sodium bicarbonate
Class :
Alkalinizing Agents, Minerals and electrolytes, Urinary pH modifiers
Dosage Forms & Strengths
Tablet
325 mg
650 mg
Starting dose of 1 milliequivalent/kg intravenously once and adjust subsequent doses based on arterial blood pH and PaCO2 results, as well as base deficit calculation
Not posing a threat to life: Intravenous infusion of 2 to 5 milliequivalents/kg over a period of 4 to 8 hours based on the severity of acidosis as determined by the decrease in total CO2 content, clinical state and pH.
Severe (except hyper carbic acidosis): 90 to 180 milliequivalents/liter at a pace of 1 to 1.5 liters during the first hour and adjust for subsequent treatment as required
Dosing Considerations
Observe serum potassium, carbon di oxide and pH
Dosage Forms & Strengths
Tablet
325 mg
650 mg
For older children: Administer an intravenous infusion of 2 to 5 milliequivalent/kg over a period of 4 to 8 hours, depending on the extent of acidosis as determined by the decrease in total CO2 content, clinical condition and pH level
In cases of acidosis with a pH level below 7.0 to 7.2, an intravenous infusion of 0.25 to 2 milliequivalent/kg can be considered
Dosing Considerations
Observe the serum potassium
Refer to adult dosing
it may decrease the excretion of amphetamines
may diminish the excretion of amphetamines
It may diminish the excretion when combined with alkalinizing agents.
may increase the levels of serum concentration of alpha-/beta-agonists
may reduce the rate of excretion of amphetamines
may reduce the rate of excretion of amphetamines
may reduce the rate of excretion of amphetamines
may reduce the rate of excretion of amphetamines
may reduce the rate of excretion of amphetamines
May increase the levels of serum concentration
may increase the serum concentration
may increase the serum concentration
may increase the serum concentration
may increase the serum concentration
may increase the serum concentration
sodium bicarbonate: they may diminish the excretion of flecainide
alkalinizing agents: they may enhance the serum concentration of Alpha or Beta-Agonists
alkalinizing agents: they may enhance the serum concentration of Alpha or Beta-Agonists
it may increase the level of serum concentration of memantine
may decrease the effects of the drug by GI absorption inhibition
may decrease the rate of excretion of amphetamines
may decrease the rate of excretion of amphetamines
may decrease the rate of excretion of amphetamines
may decrease the rate of excretion of amphetamines
may decrease the rate of excretion of amphetamines
hydrocodone/chlorpheniramine/pseudoephedrine
may enhance the serum concentration of alpha/beta agonists
acrivastine and pseudoephedrine
may increase the serum concentration of alpha/beta agonists
may enhance the serum concentration of amantadine
acetazolamide: they may increase the toxic effect of sodium bicarbonate
mecamylamine: they may enhance the serum concentration of alkalinizing agents
memantine: they may enhance the serum concentration of alkalinizing agents
quinidine: they may enhance the serum concentration of alkalinizing agents
quininie: they may enhance the serum concentration of alkalinizing agents
flecainide: they may diminish the excretion of alkalinizing agents
Actions and Spectrum
By neutralising excess stomach acid, sodium bicarbonate can act as an antacid, easing the symptoms of heartburn, indigestion and other stomach-related problems.
Blood and urine’s pH can be raised by sodium bicarbonate, making them more alkaline. Treatment for ailments like metabolic acidosis, in which the body overproduces acid, may benefit from this.
Sodium ions included in sodium bicarbonate can assist replace electrolytes lost as a result of vomiting, diarrhoea or excessive perspiration.
As a buffering substance, sodium bicarbonate can keep the pH balance of the body’s fluids and stop acidity variations that can cause health issues. The treatment of acid-base imbalances, digestive problems, and electrolyte imbalances are among sodium bicarbonate’s wide range of effects.
Frequency not defined
Edema
Hypernatremia
Aggravated CHF
Hypocalcemia
Tetany
Metabolic alkalosis
Pulmonary edema
Hypernatremia
Intracranial acidosis
Milk-alkali syndrome
Hyperosmolality
Cerebral hemorrhage
Hypokalemia
Belching
Gastric distension
Black Box Warning
sodium bicarbonate does not have a black box warning as per the US FDA.
Contraindication/Caution:
Pregnancy warnings:
Pregnancy category: N/A
Lactation: Excretion into human milk is unknown
Pregnancy Categories:
Category A: Studies that were well-controlled and met expectations revealed no risk to the fetus in either the first or second trimester.
<b>Category B: There were lack of studies on pregnant women and no evidence of risk to the foetus in animal experiments.
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.
Category D: adequate data available with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.
Category N: There is no data available for the drug under this category
Pharmacology
Baking soda, commonly known as sodium bicarbonate, is an alkalizing substance that balances out excess acid in the body. It comes as a crystalline, white powder that dissolves in water.
Ingestion of sodium bicarbonate causes the stomach’s hydrochloric acid to react, resulting in the production of carbon dioxide, water and sodium chloride.
Additionally serving as a buffer, sodium bicarbonate helps to keep the pH balance of the body’s fluids.
Pharmacodynamics
Because sodium bicarbonate can neutralize excess acid in the body and raise the pH of the affected area, it has pharmacodynamic properties.
By interacting with hydrogen ions (H+) to create bicarbonate ions (HCO3-) and water (H2O), sodium bicarbonate acts as an alkalizing agent.
Pharmacokinetics
Absorption
When taken orally, sodium bicarbonate is easily absorbed from the stomach and intestines. The formulation and dosage of the medication, the presence of food in the stomach, and the digestive system of the individual all affect the rate and volume of absorption.
Distribution
sodium bicarbonate is dispersed throughout the body’s fluids and tissues after absorption. The medication’s physiochemical characteristics, the blood flow to various organs, and the presence of binding proteins are only a few examples of the elements that affect drug distribution.
Metabolism
The body does not metabolize sodium bicarbonate. Instead, it is disassembled into sodium and bicarbonate ions, which are then utilized in several physiological activities.
Elimination and excretion
Urine is where sodium bicarbonate is predominantly eliminated. The medicine is removed from the blood by the kidneys and excreted in the urine.
The dosage of the medicine, the person’s kidney function and the pH of the urine are just a few examples of the variables that affect how quickly and how much is excreted.
Administration:
Depending on the purpose, sodium bicarbonate may be given orally or intravenously.
Patient information leaflet
Generic Name: sodium bicarbonate
Why do we use sodium bicarbonate?
In order to neutralise excess stomach acid and relieve the symptoms of acid indigestion, heartburn and sour stomach, sodium bicarbonate is used as an antacid.
Metabolic acidosis, a disease marked by an abnormal build-up of acid in the body, can be treated by giving sodium bicarbonate intravenously.
In addition to other therapies, sodium bicarbonate can be used to treat urinary tract infections. The medication works by alkalinizing the urine, which reduces its acidity and lessens the environment that bacteria can flourish in.
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Founded in 2014, medtigo is committed to providing high-quality, friendly physicians, transparent pricing, and a focus on building relationships and a lifestyle brand for medical professionals nationwide.
MASSACHUSETTS – USA
60 Roberts Drive, Suite 313,
North Adams, MA 01247
MAHARASHTRA – INDIA
7, Shree Krishna, 2nd Floor,
Opp Kiosk Koffee,
Shirole Lane, Off FC Road,
Pune 411004, Maharashtra
