Anthropometric Measurements as Predictors of Low Birth Weight Among Tanzanian Neonates: A Hospital-Based Study
November 7, 2025
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Brand Name :
Lupkynis
Synonyms :
voclosporin
Class :
Calcineurin Inhibitors
Brand Name :
Lupkynis
Synonyms :
voclosporin
Class :
Calcineurin Inhibitors
Dosage forms & Strengths:Â
Adult:Â
CapsuleÂ
7.9 mgÂ
In case of mild hepatic impairment, reduce the dose to 15.8 mg twice daily:
23.7
mg
Capsule
Orally 
twice a day
Safety and efficacy are not seen in pediatricsÂ
Safety and efficacy are not seen in pediatrics
Refer to adult dosingÂ
It may enhance the effect when combined with grapefruit by CYP3A4 metabolism
voclosporin: they may enhance the serum concentration of CYP3A4 Inhibitors
voclosporin: they may enhance the serum concentration of CYP3A4 Inhibitors
voclosporin: they may enhance the serum concentration of CYP3A4 Inhibitors
voclosporin: they may enhance the serum concentration of CYP3A4 Inhibitors
voclosporin: they may enhance the serum concentration of CYP3A4 Inhibitors
voclosporin: they may diminish the serum concentration of CYP3A4 Inducers
voclosporin: they may diminish the serum concentration of CYP3A4 Inducers
voclosporin: they may diminish the serum concentration of CYP3A4 Inducers
voclosporin: they may diminish the serum concentration of CYP3A4 Inducers
voclosporin: they may diminish the serum concentration of CYP3A4 Inducers
when both drugs are combined, there may be an increased risk or severity of adverse effects  
when both the drugs are combined, the risk or severity of adverse effects increases    
when both drugs are combined, there may be an increased risk of serious infections    
the effect of voclosporin is decreased by lorlatinib, by altering intestinal or hepatic CYP3A4 enzyme metabolism
CYP3A strong enhancers of the small intestine may reduce the bioavailability of voclosporin
may increase the levels serum concentration of OATP1B1/1B3 (SLCO1B1/1B3) substrates
may increase the levels serum concentration of OATP1B1/1B3 (SLCO1B1/1B3) substrates
may increase the levels serum concentration of OATP1B1/1B3 (SLCO1B1/1B3) substrates
may increase the levels serum concentration of OATP1B1/1B3 (SLCO1B1/1B3) substrates
may increase the levels serum concentration of OATP1B1/1B3 (SLCO1B1/1B3) substrates
It may enhance the metabolism when combined with dexamethasone
It may enhance QTc interval when combined with lithium
the peril or acuteness of adverse effects can be elevated when stepronin is combined with voclosporin
when voclosporin and melphalan combine the immunosuppressive effects of both the drugs are enhanced and lead to increased risk of infection
when both drugs are combined, there may be an increased risk of nephrotoxicity and ototoxicity  
may raise the risk of nephrotoxicity
may raise the risk of nephrotoxicity
when both drugs are combined, there may be an increased risk of adverse effects  
may raise the risk of nephrotoxicity
may raise the risk of nephrotoxicity
interaction with voclosporin may increase the risk of nephrotoxicity
interaction with voclosporin may increase the risk of nephrotoxicity
voclosporin may enhance the chances of nephrotoxicity
voclosporin may enhance the chances of nephrotoxicity
it increases the concentration of OATP1B1/1B3 substrates in serum
may enhance the serum concentration
the activity of the anthrax vaccine can be reduced when used in combination with voclosporin
increased serum concentration of methotrexate may lead to toxic effects
increased serum concentration of trimetrexate may lead to toxic effects
>10%:Â
Decreased GFRÂ
Headache Â
Hypertension Â
Diarrhea Â
CoughÂ
Anemia Â
1-10%:Â
Urinary tract infection Â
Dyspepsia Â
Upper abdominal pain Â
Abdominal pain Â
Alopecia Â
Renal Impairment Â
Fatigue Â
Decreased appetite Â
Mouth ulceration Â
Gingivitis Â
Tremor Â
Acute kidney injury Â
HypertrichosisÂ
Frequency undefined:Â
PneumoniaÂ
Herpes ZosterÂ
Increased blood creatinineÂ
GastroenteritisÂ
Renal failureÂ
AzotemiaÂ
QT prolongationÂ
Cytomegalovirus infectionÂ
OliguriaÂ
HyperkalemiaÂ
ProteinuriaÂ
Voclosporin is contraindicated in patients hypersensitive to the active ingredient.Â
Pregnancy consideration:Â Â
The drug is not recommended during pregnancy.Â
Breastfeeding warnings:Â Â
No data is available regarding the excretion of the drug in breast milk.Â
Pregnancy category:Â
Patient information leafletÂ
Generic Name: voclosporinÂ
Pronounced: vok-loe-spo-rinÂ
Why do we use voclosporin?Â
Voclosporin is a calcineurin inhibitor. It is used to treat lupus nephritis.  Â
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