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Brand Name :
Zonegran, zonisade
Synonyms :
zonisamide
Class :
Anti convulsants
Brand Name :
Zonegran, zonisade
Synonyms :
zonisamide
Class :
Anti convulsants
Dosage Forms & Strengths
Capsule
25mg
100mg
100
mg
capsule
Orally
every day
increase up to 200mg/day twice a day after two weeks
Do not exceed 600mg/day
Dosage Forms & Strengths
Capsule
25mg
100mg
<16 years:
Safety and efficacy not established
>16 years:
100mg orally every day,increase up to 200mg/day twice a day after two weeks
Do not exceed 600mg/day
Refer adult dosing
may increase the level of zonisamide by affecting the hepatic enzyme CYP3A4 metabolism
may increase the level of zonisamide by affecting the hepatic enzyme CYP3A4 metabolism
may increase the level of zonisamide by affecting hepatic enzyme CYP3A4 metabolism
may increase the level of zonisamide by affecting hepatic enzyme CYP3A4 metabolism
may increase the level of zonisamide by affecting hepatic enzyme CYP3A4 metabolism
may increase the risk of sedation
may increase the level by affecting hepatic enzyme CYP3A4 metabolism
may increase the level by affecting hepatic enzyme CYP3A4 metabolism
CYP3A strong enhancers of the small intestine may reduce the bioavailability of zonisamide
may alter the level by affecting CYP450 enzyme metabolism
may alter the level by affecting CYP450 enzyme metabolism
may alter the level by affecting CYP450 enzyme metabolism
may alter the level by affecting CYP450 enzyme metabolism
may increase the level by affecting the hepatic enzyme CYP3A4 metabolism
may decrease the level by affecting the hepatic enzyme CYP3A4 metabolism
may increase the level by affecting the hepatic enzyme CYP3A4 metabolism
may decrease the rate of excretion of amphetamines
may decrease the rate of excretion of amphetamines
may decrease the rate of excretion of amphetamines
may decrease the rate of excretion of amphetamines
may decrease the rate of excretion of amphetamines
may increase the risk of adverse effects
may increase the risk of adverse effects
may increase the risk of adverse effects
may increase the risk of adverse effects
may increase the risk of adverse effects
may increase the risk of adverse effect
may increase the risk of adverse effect
may increase the risk of adverse effect
may increase the risk of adverse effect
may increase the risk of adverse effect
may increase the risk of adverse effects
may increase the risk of adverse effects
may increase the risk of adverse effects
may increase the risk of adverse effects
may increase the risk of adverse effects
may increase the risk of adverse effect
may increase the risk of adverse effect
may increase the risk of adverse effect
may increase the risk of adverse effect
may increase the risk of adverse effect
may increase the risk of adverse effect
may increase the risk of adverse effect
may increase the risk of adverse effect
the excretion rate of gadopentetic acid may be increased by zonisamide, potentially leading to a lower serum level and a potential reduction in efficacy
zonisamide may increase the excretion rate of ioxilan, potentially resulting in a lower serum level and potentially a reduction in efficacy
isoxicam may increase the risk or severity of hyperkalemia when combined with zonisamide
zonisamide may increase the excretion rate of phylloquinone, potentially resulting in lower serum levels and a potential reduction in efficacy
muzolimine may increase the excretion rate of zonisamide, potentially resulting in a lower serum level and a potential reduction in efficacy
zonisamide has the potential to increase the excretion rate of mycophenolic acid, potentially resulting in a lower serum level and reduced efficacy
zonisamide may increase the excretion rate of n-acetyl tyrosine, potentially resulting in a lower serum level and potentially reducing efficacy
zonisamide may raise the excretion rate of sulbactam, potentially resulting in a lower serum level and potentially reducing efficacy
the risk of hyperkalemia can be raised when sulindac used in combination
prenylamine may augment the arrhythmogenic activities of zonisamide
the serum concentration of zonisamide can be raised when combined with ivacaftor
fedratinib increases the effect of mestranol by altering the intestinal/ hepatic CYP3A4 enzyme metabolism
the rate of metabolism of zonisamide may be increased when taken with fluocortolone
combining with asunaprevir can result in a decreased metabolism of zonisamide
the risk of dehydration can be increased
the risk of hyperkalemia may be increased
the risk of cardiac arrhythmia may be increased
the efficacy of phosphoric acid may be decreased due to an increase in rate of excretion
the risk of hyperglycemia may be enhanced
may decrease the level of each other by increasing metabolism
may increase the level by affecting the hepatic enzyme CYP3A4 metabolism
may increase the level by affecting the hepatic enzyme CYP3A4 metabolism
may decrease the level by affecting the hepatic enzyme CYP3A4 metabolism
may decrease the level by affecting the hepatic enzyme CYP3A4 metabolism
may increase the level by affecting the hepatic enzyme CYP3A4 metabolism
may decrease the level by affecting the hepatic enzyme CYP3A4 metabolism
may increase the level by affecting the hepatic enzyme CYP3A4 metabolism
may increase the level by affecting the hepatic enzyme CYP3A4 metabolism
may decrease the level by affecting the hepatic enzyme CYP3A4 metabolism
may increase the level by affecting the hepatic enzyme CYP3A4 metabolism
may diminish the effects of pharmacodynamic antagonism
may increase the level by affecting hepatic enzyme CYP3A4 metabolism
may diminish the effects of pharmacodynamic antagonism
Frequency defined:
>10%
Dizziness
Somnolence
Anorexia
1-10%
Agitation
Ataxia
Abdominal pain
Depression
Insomnia
Paresthesia
Weight loss
Mental slowing
Xerostomia
Taste perversion
<1%
Allergic reaction
Anemia
Leg cramps
Pharyngitis
Amblyopia
Urticaria
Acne
Euphoria
Vertigo
Apnea
Post-marketing reports
Acute pancreatitis
Acute myopia
Encephalopathy
Pregnancy consideration: C
Lactation: The drug is excreted in the human breast milk
Pregnancy category:
Patient information leaflet
Generic Name: zonisamide
Pronounced: zoh-NIH-sah-mide
Why do we use zonisamide?
It is used to treat partial seizures.
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