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Brand Name :
N/A
Synonyms :
dimethylaminoantipyrine, aminopyrine, aminophenazonum ,aminophenazone
Class :
Pyrazolones Analgesic & Antipyretic
Brand Name :
N/A
Synonyms :
dimethylaminoantipyrine, aminopyrine, aminophenazonum ,aminophenazone
Class :
Pyrazolones Analgesic & Antipyretic
Dosage forms and strengths Â
Tablet (film coated)Â
250 mgÂ
300 mgÂ
Indicated for Acute migraine
In-vivo studies suggest 250 to 300 mg every 6 to 8 hours orally daily
Not indicatedÂ
Refer adult dosingÂ
aminophenazone: it may increase the risk of methemoglobinemia agents
aminophenazone: it may increase the risk of methemoglobinemia agents
aminophenazone: it may increase the risk of methemoglobinemia agents
aminophenazone: it may increase the risk of methemoglobinemia agents
aminophenazone: it may increase the risk of methemoglobinemia agents
may enhance the severity of adverse effects when combined
may enhance the severity of adverse effects when combined
may enhance the severity of adverse effects when combined
may enhance the severity of adverse effects when combined
may enhance the severity of adverse effects when combined
When suprofen is taken in conjunction with aminophenazone, there is a potential for an enhance in the seriousness of adverse events
levobetaxolol's antihypertensive properties may be reduced by aminophenazone
The effectiveness of mibefradil may be diminished when utilized concurrently with aminophenazone
Combining aminophenazone with pranlukast may cause a reduction in the aminophenazone’s metabolism
Combining tegafur with aminophenazone can reduce tegafur’s metabolism
When loracarbef is used together with aminophenazone, the risk or seriousness of nephrotoxicity is enhanced
When aminophenazone is used together with hexoprenaline, the potential for hypertension to occur may be elevated
When aminophenazone is used together with sertraline, the risk or seriousness of bleeding may be enhanced
When aminophenazone is used together with fluconazole, this leads to reduction in the aminophenazone metabolism
When aminophenazone is used together with piroxicam, this leads to enhanced risk or seriousness of adverse outcomes
When aminophenazone is used together with somatotropin, this leads to a rise in aminophenazone’s metabolism
When antrafenine is used together with aminophenazone, this leads to enhanced risk or seriousness of adverse outcomes
When aminophenazone is used together with cephaloglycin, this leads to increased risk or seriousness of nephrotoxicity
When melitracen is used together with aminophenazone, this leads to increased risk or seriousness of gastrointestinal bleeding
When aminophenazone is used together with promazine, this leads to a reduction in aminophenazone metabolism
When aminophenazone is used together with andrographolide, this leads to enhanced risk or seriousness of bleeding
When aminophenazone is used together with proglumetacin, this leads to enhanced risk or seriousness of adverse events
When aminophenazone is used together with bufexamac, this leads to enhanced risk or seriousness of adverse events
When aminophenazone is used together with benoxaprofen, this leads to enhanced risk or seriousness of adverse events
aminophenazone leads to a reduction in the rate of excretion of eucalyptus oil which leads to increased level of serum
aminophenazone leads to a reduction in the rate of excretion of chromous sulfate, which leads to an increased level of serum
aminophenazone leads to a reduction in the rate of excretion of pentaerythritol tetranitrate, which leads to an increased level of serum
aminophenazone leads to a reduction in the rate of excretion of nitric oxide, which leads to an increased level of serum
When indisulam is used together with aminophenazone, this leads to a reduction in aminophenazone metabolism
When aminophenazone is used together with nifenazone, this leads to enhanced risk or seriousness of adverse events
the metabolism of aminophenazone can be decreased when combined with oxycodone
aminophenazone: it may increase the risk of bleeding with trapidil
aminophenazone: it may decrease the excretion rate of acrivastine
aminophenazone may decrease the excretion rate of almasilate, leading to higher serum levels
When aminophenazone is used together with diazoxide, this leads to reduction in therapeutic effectiveness of diazoxide
aminophenazone: it may increase the risk of nephrotoxicity with ceforanide
may enhance the risk or severity of hypertension when combined
may increase the risk or severity of hypertension when combined
may increase the levels of serum concentration
may increase the levels of serum concentration
may increase the levels of serum concentration
may increase the levels of serum concentration
may increase the levels of serum concentration
aminophenazone has the potential to reduce the rate of excretion of abacavir, leading to an elevation in its concentration serum
When aminophenazone is taken together with acemetacin, there is a potential for an elevated risk or enhanced seriousness of adverse events
When aminophenazone is taken together with acelofenac, there is a potential for an elevated risk or enhanced seriousness of adverse events
When aminophenazone is taken together with acetaminophen, there is a potential for an elevated risk or enhanced seriousness of adverse events
aminophenazone has the potential to reduce the rate of excretion of aclidinium, leading to an elevation in its serum concentration
aminophenazone has the potential to reduce the rate of excretion of acrivastine leading to an elevation in its serum concentration
When aminophenazone is taken together with acetylsalicylic acid, there is a potential for an elevated risk or enhanced seriousness of adverse events
may increase the risk of hypertension when combined
may have a decrease in excretion when combined with aminophenazone
the risk of adverse effects may be increased
the risk of hypertension may be increased
when coupled with fosnetupitant, aminophenazone's metabolism can be slowed down
the rate of metabolism of aminophenazone may be reduced
When aminophenazone is used together with oliceridine, this leads to reduction in oliceridine’s metabolism
aminophenazone might lead to a reduction in the rate of excretion of telavancin, potentially leading to elevated levels of serum
Actions and Spectrum:Â
Action:Â
Analgesic: aminophenazone exhibits analgesic properties, which means it can alleviate pain. It works by inhibiting certain enzymes (cyclooxygenase) involved in prostaglandin synthesis, thereby reducing inflammation and pain signals.Â
Antipyretic: aminophenazone is effective in reducing fever (antipyretic action). It acts on the hypothalamus, a region in the brain that regulates body temperature, and helps to lower elevated body temperatures during febrile conditions.Â
Spectrum:Â
Pain relief: aminophenazone can alleviate various types of mild to moderate pain, such as muscle pain, menstrual cramps, dental pain, headache and other non-specific pains.Â
Fever reduction: It is used to lower elevated body temperature in cases of fever caused by infections or other febrile conditions.Â
Â
Frequency not defined Â
AgranulocytosisÂ
Acute attacks of porphyria
Black Box Warning:Â Â
None
Contraindication/Caution:Â Â
Hypersensitivity or Allergy: Individuals who have previously shown hypersensitivity or allergic reactions to aminophenazone or related drugs (e.g., pyrazolone derivatives) should not use this medication.Â
Blood Disorders: Blood disorders such as agranulocytosis (severe reduction in white blood cells), aplastic anemia, or other blood-related abnormalities should avoid using aminophenazone due to the risk of exacerbating these conditions.Â
Liver Dysfunction: aminophenazone is primarily metabolized in the liver, and individuals with severe liver impairment should not use this medication, as it may lead to drug accumulation and potential toxicity.Â
Severe Renal Impairment: aminophenazone is excreted through the kidneys, and patients with severe kidney dysfunction should avoid using this medication to prevent drug accumulation and potential adverse effects.Â
Porphyria: aminophenazone can exacerbate porphyria, an uncommon genetic disorders that impact heme production within the body. People with porphyria should not use this medication.Â
Pregnancy and Breast-feeding: aminophenazone use during pregnancy and breast-feeding should be avoided unless specifically prescribed by a healthcare professional due to potential risks to the developing fetus or nursing infant.Â
Children and Adolescents with Viral Infections: aminophenazone has been associated Reye’s syndrome, a rare yet severe condition that affects the liver and brain, especially in children and adolescents who have viral infections, notably influenza and chickenpox. Consequently, it is advised not to use aminophenazone in such instances.Â
Pregnancy warnings:    Â
Pregnancy category: N/AÂ
Lactation: Excreted into human milk is unknownÂ
Pregnancy Categories:        Â
Category A: Studies that were well-controlled and met expectations revealed no risk to the fetus in either the first or second trimester.Â
<b>Category B: There were a lack of studies on pregnant women and no evidence of risk to the fetus in animal experiments.  Â
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.   Â
Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.  Â
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.   Â
Category N: There is no data available for the drug under this category
Pharmacology:Â Â
aminophenazone, or aminopyrine, is a non-opioid analgesic and antipyretic drug.Â
Pharmacodynamics:Â Â
Analgesic Effect: aminophenazone works by inhibiting the synthesis of prostaglandins, which are chemical mediators involved in the transmission of pain signals. By reducing prostaglandin levels, it helps alleviate pain and discomfort.Â
Antipyretic Effect: Like other non-steroidal anti-inflammatory drugs (NSAIDs), aminophenazone can lower fever by acting on the hypothalamic heat-regulating center, reducing the body’s temperature set point.  Â
Pharmacokinetics:Â
AbsorptionÂ
aminophenazone, also known as aminopyrine, is absorbed after oral administration. quickly absorbed from the GI tract and achieves its highest levels in the bloodstream within 1 to 2 hours.Â
DistributionÂ
Once absorbed, aminophenazone is distributed throughout the body via the bloodstream. It is known to have a moderate volume of distribution, indicating that it can distribute well in the extracellular fluids.Â
MetabolismÂ
aminophenazone undergoes extensive metabolism in the liver. The major metabolic pathway involves N-demethylation by the cytochrome P450 enzymes, mainly CYP1A2 and CYP2E1. This process leads to the formation of several metabolites, including dimethylaminophenazone, monomethylaminophenazone, and dimethylaminopyrazole.Â
Excretion and EliminationÂ
The primary route of excretion for aminophenazone and its metabolites is through the urine. After metabolism, the resulting metabolites are eliminated through the kidneys and excreted in the urine. Only a small percentage of the drug is excreted unchanged in the urine.Â
Administration: Â
The route of administration is oral.Â
Patient information leafletÂ
Generic Name: aminophenazoneÂ
Why do we use aminophenazone? Â
Pain relief: aminophenazone had been widely utilized for alleviating mild to moderate pain conditions, such as headaches, dental pain, and musculoskeletal discomfort.Â
Fever reduction: It was used to reduce fever associated with various conditions, such as infections and inflammatory diseases. Â
Combination with other drugs: aminophenazone was often used in combination with other drugs to enhance their effectiveness in relieving pain and reducing fever.Â
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