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Brand Name :
Stakane
Synonyms :
antrafenine
Class :
Analgesics
Brand Name :
Stakane
Synonyms :
antrafenine
Class :
Analgesics
The recommended dose is to take 450 mg-900 mg daily
The treatment duration is two weeks
Not indicatedÂ
Refer adult dosingÂ
may diminish the excretion rate of each other when combined
may increase the risk of hypertension when combined
may diminish the metabolism of each other when combined
may diminish the metabolism of each other when combined
may diminish the metabolism of each other when combined
may diminish the metabolism of each other when combined
may diminish the metabolism of each other when combined
may reduce the therapeutic effect
may reduce the therapeutic effect
may reduce the therapeutic effect
levobetaxolol's antihypertensive effects might be reduced by antrafenine
antrafenine has the potential to reduce the rate of excretion of levobupivacaine, potentially leading to elevated levels of serum
antrafenine has the potential to reduce the rate of excretion of idebenone, leading to an elevation in levels of serum
It may enhance the risk of adverse effects when combined with Glycopeptides
It may enhance the risk of adverse effects when combined with Glycopeptides
When loracarbef is used together with antrafenine, the risk or seriousness of nephrotoxicity is enhanced
When antrafenine is used together with hexoprenaline, the potential for hypertension to occur may be elevated
When antrafenine is used together with sertraline, the risk or seriousness of bleeding may be enhanced
When antrafenine is used together with piroxicam, this leads to enhanced risk or seriousness of adverse outcomes
When antrafenine is used together with cephaloglycin, this leads to increased risk or seriousness of nephrotoxicity
When melitracen is used together with antrafenine, this leads to increased risk or seriousness of gastrointestinal bleeding
When antrafenine is used together with andrographolide, this leads to enhanced risk or seriousness of bleeding
When cefmenoxime is used together with antrafenine, this leads to enhanced risk or seriousness of nephrotoxicity
When antrafenine is used together with proglumetacin, this leads to enhanced risk or seriousness of adverse events
When antrafenine is used together with bufexamac, this leads to enhanced risk or seriousness of adverse events
when antrafenine is taken with lonazolac, the chance or severity of undesirable effects can be enhanced
When antrafenine is used together with benoxaprofen, this leads to enhanced risk or seriousness of adverse events
antrafenine leads to a reduction in the rate of excretion of eucalyptus oil which leads to increased level of serum
antrafenine leads to a reduction in the rate of excretion of chromous sulfate, which leads to an increased level of serum
antrafenine leads to a reduction in the rate of excretion of pentaerythritol tetranitrate, which leads to an increased level of serum
When lopinavir is used together with antrafenine, this leads to enhanced risk or seriousness of nephrotoxicity
antrafenine leads to a reduction in the rate of excretion of nitric oxide, which leads to an increased level of serum
When antrafenine is used together with nifenazone, this leads to enhanced risk or seriousness of adverse events
When antrafenine is used together with difenpiramide, this leads to increased risk or seriousness of adverse events
the chances of adverse effects may be increased when antrafenine is combined with morniflumate
the risk or extent of hypertension can be raised when antrafenine is combined with isometheptene
antrafenine may decrease the excretion rate of almasilate, leading to higher serum levels
When antrafenine is used together with diazoxide, this leads to reduction in therapeutic effectiveness of diazoxide
antrafenine: it may increase the neuroexcitatory activities of rosoxacin
may enhance the risk or severity of hypertension when combined
may increase the levels of serum concentration
may increase the levels of serum concentration
may increase the levels of serum concentration
may increase the levels of serum concentration
may increase the levels of serum concentration
It may enhance the serum concentration when combined with CYP3A4 Substrates
It may enhance the serum concentration when combined with CYP3A4 Substrates
It may enhance the serum concentration when combined with CYP3A4 Substrates
It may enhance the serum concentration when combined with CYP3A4 Substrates
It may enhance the serum concentration when combined with CYP3A4 Substrates
When antrafenine is used together with aceclofenac, this leads to enhanced risk or seriousness of adverse outcomes
When antrafenine is used together with acemetacin, this leads to enhanced risk or seriousness of adverse outcomes
When antrafenine is used together with acetaminophen, this leads to enhanced risk or seriousness of adverse outcomes
When antrafenine is used together with alendronic acid, this leads to enhanced risk or seriousness of adverse outcomes
When antrafenine is used together with alclofenac, this leads to enhanced risk or seriousness of adverse outcomes
When antrafenine is used together with aminophenazone, this leads to enhanced risk or seriousness of adverse outcomes
When antrafenine is used together with antipyrine, this leads to enhanced risk or seriousness of adverse outcomes
When antrafenine is used together with azficel-T, this leads to enhanced risk or seriousness of adverse outcomes
the risk of gastrointestinal bleeding may be increased
the risk of hypertension may be increased
antrafenine might lead to a reduction in the rate of excretion of telavancin, potentially leading to elevated levels of serum
Actions and Spectrum:Â
Action: antrafenine primarily acts by inhibiting cyclooxygenase enzymes (COX-1 and COX-2). These enzymes play a crucial role in synthesizing prostaglandins, which are lipid compounds that mediate pain, inflammation, and fever. By inhibiting COX enzymes, antrafenine reduces the production of prostaglandins, leading to decreased pain and inflammation in the body.Â
Spectrum:Â
Pain Relief: antrafenine can alleviate mild to moderate pain, such as headaches, dental pain, menstrual cramps, and musculoskeletal pain.Â
Inflammation: It is useful in reducing inflammation associated with conditions like rheumatoid arthritis, osteoarthritis, and other inflammatory disorders.Â
Frequency not defined Â
Rash Â
Abdominal painÂ
NauseaÂ
headacheÂ
Black Box Warning:Â Â
None
Contraindication/Caution:Â Â
Hypersensitivity: antrafenine should not be used if an individual has a known hypersensitivity or allergy to the drug or any other NSAIDs.Â
Active Peptic Ulcer Disease: NSAIDs can increase gastrointestinal bleeding risk and exacerbate peptic ulcers. antrafenine is generally contraindicated in individuals with active peptic ulcer disease.Â
Gastrointestinal Bleeding: If a patient has a history of gastrointestinal bleeding, antrafenine should be avoided as it can increase the risk of recurrent bleeding.Â
Severe Renal Impairment: antrafenine can affect kidney function, and in cases of severe renal impairment, it should be used with caution or avoided altogether.Â
Severe Liver Disease: Individuals with severe liver disease should avoid antrafenine, as it can further impair liver function.Â
Pregnancy and Lactation: antrafenine should be avoided during pregnancy, particularly in the third trimester, as it may result in difficulties for both the mother and the fetus, it is also best to avoid it during lactation, as it may pass into breast milk.Â
Children and Adolescents: antrafenine may not be suitable for children and adolescents, and a healthcare professional should guide its use.Â
Pregnancy warnings:    Â
Pregnancy category: N/AÂ
Lactation: Excreted into human milk is unknownÂ
Pregnancy Categories:        Â
Category A: Studies that were well-controlled and met expectations revealed no risk to the fetus in either the first or second trimester.Â
Category B: There were a lack of studies on pregnant women and no evidence of risk to the fetus in animal experiments.  Â
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.   Â
Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.  Â
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.   Â
Category N: There is no data available for the drug under this category
Pharmacology: antrafenine is an NSAID used to relieve pain and reduce inflammation.Â
Pharmacodynamics:Â Â
The complete mechanism of its action remains unclear; however, its capacity to inhibit the production of prostaglandins may play a role in its anti-inflammatory properties. Â
Pharmacokinetics:Â
AbsorptionÂ
antrafenine is typically administered orally, and its absorption occurs primarily in the gastrointestinal tract, mainly in the stomach and small intestine.Â
DistributionÂ
Due to its lipophilic nature, antrafenine is distributed throughout the body, including in tissues and plasma.Â
MetabolismÂ
antrafenine undergoes hepatic metabolism in the liver. The major metabolic pathway involves cytochrome P450 enzymes, primarily CYP2C9 and CYP2C19.Â
Excretion and EliminationÂ
The elimination of antrafenine and its metabolites occurs primarily through the renal route.Â
Roughly 60 to 70% of the administered dosage is eliminated through urinary excretion in the form of metabolites.Â
A smaller fraction is eliminated through feces.Â
The elimination half-life of Antrafenine is typically around 2-3 hours in healthy individuals.Â
Administration: Â
The recommended dosage of antrafenine may vary depending on the patient’s age, weight, medical condition, and the severity of the treated condition. It is essential to follow the prescribing physician’s instructions or the product labeling for the accurate dosage.Â
Patient information leafletÂ
Generic Name: antrafenineÂ
Why do we use antrafenine? Â
antrafenine is indicated for the relief of mild to moderate pain. It serves as an analgesic agent, making it valuable in managing various painful conditions such as musculoskeletal pain, postoperative pain, dental pain, and headache.Â
As an NSAID, antrafenine exerts its anti-inflammatory effects by inhibiting the production of prostaglandins, which are involved in the inflammatory response, because of this characteristic, it can be beneficial in the treatment of inflammatory diseases such osteoarthritis and rheumatoid arthritis.Â
antrafenine possesses antipyretic properties, allowing it to lower elevated body temperature in individuals with fever. It is an option for the treatment of fever associated with various causes, including infections and inflammatory disorders.Â
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