benzydamine

Indicated for Radiation-Associated Mucositis
:

Rinse your mouth with 15 mL (for 30 seconds, then spit it out). Every 3-4 hours
Start taking it one day before radiation therapy and keep doing it daily while getting radiation.

Indicated for acute pharyngitis:

15 mL should be gargled or rinsed in the mouth for 30 seconds before being expelled every 1.5 to 3 hours

Dosage Forms & Strengths

Oral Rinse

0.15%

Children more than 6 years and adults-Oral rinse
Rinse your mouth with 15 mL (for 30 seconds, then spit it out). Every 3-4 hours
Start taking it one day before radiation therapy and keep doing it daily while getting radiation.

Children more than 6 years and adults: 15 mL should be gargled or rinsed in the mouth for 30 seconds before being expelled every 1.5 to 3 hours

Refer adult dosing

Frequency defined

1-10%

Nausea

Numbness

Burning sensation

Frequency Not Defined

Drowsiness

Headache

Cough

Dry mouth

Pharyngeal irritation

Black box warning:

None

Contraindications/caution:

Contraindications:

Hypersensitivity

Caution:

Allergic Reactions: Some individuals may be allergic to benzydamine or its components. If you experience signs of an allergic reaction, such as rash, itching, swelling, or difficulty breathing, seek immediate medical attention.
Hypersensitivity Reactions: benzydamine can cause hypersensitivity reactions in some individuals. If you experience any unusual or severe skin reactions, discontinue use, and consult a healthcare professional.
Avoid Contact with Eyes: benzydamine products, especially oral rinses or sprays, should not come into direct contact with the eyes. If accidental eye contact occurs, rinse thoroughly with water and seek medical attention if irritation persists.

Pregnancy consideration: Insufficient data available

Lactation: Excretion of the drug in human breast milk is unknown

Pregnancy category:

Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester.

Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.

Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.   

Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.   

Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.   

Category N: There is no data available for the drug under this category

Pharmacology:

benzydamine is a nonsteroidal anti-inflammatory drug (NSAID) with local analgesic and anti-inflammatory properties. Its pharmacology involves several mechanisms of action:

Inhibition of Prostaglandin Synthesis: benzydamine inhibits the synthesis of prostaglandins, inflammatory mediators derived from arachidonic acid. It achieves this by blocking the enzyme cyclooxygenase (COX), specifically the COX-1 and COX-2 isoforms. By inhibiting COX, benzydamine helps reduce the production of prostaglandins, which are involved in the inflammatory process.
Local Anesthetic Effect: benzydamine possesses local anesthetic properties, which can block nerve impulses and provide analgesic (pain-relieving) effects. It is believed to inhibit the influx of sodium ions into nerve cells, reducing their ability to transmit pain signals.
Stabilization of Cell Membranes: benzydamine has been shown to stabilize cell membranes, which helps reduce the release of inflammatory mediators and the subsequent inflammation response.
Anti-inflammatory Effect: By inhibiting prostaglandin synthesis and reducing the release of inflammatory mediators, benzydamine exerts an anti-inflammatory effect. It helps alleviate pain, swelling, and redness associated with inflammatory conditions.
Vasodilation: benzydamine can induce vasodilation, which is the widening of blood vessels. This property can improve blood flow and microcirculation in the affected area, aiding in the resolution of inflammation and promoting tissue healing.

Pharmacodynamics:

The pharmacodynamics of benzydamine refers to the effects and interactions of the medication with various receptors and systems in the body.

Pharmacokinetics:

Absorption

benzydamine is well absorbed when administered orally. The oral rinse form allows absorption through the oral mucosa, providing direct access to the bloodstream. The extent of absorption may vary depending on the formulation and individual factors.

Distribution

benzydamine is distributed throughout the body, reaching various tissues and organs. It has a moderate volume of distribution, indicating that it distributes well beyond the plasma compartment.

Metabolism

benzydamine undergoes limited metabolism in the liver. Most of the drug is excreted unchanged in the urine. The specific metabolic pathways and the involvement of enzymes in benzydamine metabolism need to be better characterized.

Elimination and Excretion

benzydamine is primarily excreted unchanged in the urine. The unchanged drug is eliminated from the body through renal excretion. The specific excretion pathways and elimination half-life of benzydamine need to be well documented.

Administration:

The patient should not consume the liquid after the rinsing. Dilute 1:1 in lukewarm water if there is local irritation or burning.
Mucositis: Rinse for 30 seconds to keep in touch with the irritated mucosa before spitting; start treatment one day before radiation therapy; maintain daily during radiation therapy; and continue daily after radiation therapy is finished until sufficient healing occurs.
Gargle and spit for pharyngitis.

Patient information leaflet

Generic Name: benzydamine

Why do we use benzydamine?

benzydamine is primarily used for its local analgesic and anti-inflammatory properties. It is available for topical use in various formulations, including oral rinses, gels, and sprays. Here are some common uses of benzydamine:

Oropharyngeal Conditions: benzydamine is frequently used as an oral rinse or spray to relieve pain and reduce inflammation associated with conditions such as sore throat, mouth ulcers, pharyngitis, and post-operative oral procedures.
Gingivitis and periodontitis: benzydamine can alleviate pain and inflammation in the gums caused by gingivitis (inflammation of the gums) or periodontitis (inflammation of the tissues supporting the teeth).
Post-Dental Procedures: benzydamine is often prescribed following dental procedures, such as extractions or periodontal surgeries, to relieve pain and reduce inflammation in the oral cavity.
Sore Throat: benzydamine can help soothe the discomfort associated with sore throat due to viral or bacterial infections.
Inflammatory Conditions: benzydamine may be used for localized pain and inflammation relief in conditions like musculoskeletal injuries, sprains, strains, sports injuries, and other inflammatory conditions affecting the joints, muscles, or tendons.

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benzydamine

Brand Name :

Pharixia, PMS-Benzydamine, Odan-Benzydamine, Pharixia Alcohol-Free, Tantum Oral Rinse

Synonyms :

benzydamine

Class :

Oral, Local Anaesthetic Locally Applied Anti-inflammatory

Dosage Forms & Strengths

Oral Rinse

0.15%

Indicated for Radiation-Associated Mucositis
:

Rinse your mouth with 15 mL (for 30 seconds, then spit it out). Every 3-4 hours
Start taking it one day before radiation therapy and keep doing it daily while getting radiation.

Indicated for acute pharyngitis:

15 mL should be gargled or rinsed in the mouth for 30 seconds before being expelled every 1.5 to 3 hours

Dosage Forms & Strengths

Oral Rinse

0.15%