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Brand Name :
Laxonalin, Wylaxin
Synonyms :
bisoxatin, bisoxatinum, bisoxatina
Class :
Contact laxatives & diphenylmethanes
Brand Name :
Laxonalin, Wylaxin
Synonyms :
bisoxatin, bisoxatinum, bisoxatina
Class :
Contact laxatives & diphenylmethanes
Dosage Forms & Strengths
Tablet
120mg
120
mg
Tablet
Orally
Once a day in the night
120mg orally once a day at night
Data not available
Refer to adult dosing
the excretion rate of bisoxatin may be decreased with sucralfate leading to higher concentration in serum
the excretion rate of bisoxatin may be decreased with aceclofenac leading to higher concentration in serum
severe dehydration may occur when acetazolamide is taken with bisoxatin
the excretion rate of bisoxatin may be decreased with alprazolam leading to higher concentration in serum
the excretion rate of bisoxatin may be reduced with sulindac
the excretion rate of bisoxatin may be decreased with ranitidine leading to higher concentration in serum
bisoxatin: it may increase the risk of methemoglobinemia agents
bisoxatin: it may increase the risk of methemoglobinemia agents
bisoxatin: it may increase the risk of methemoglobinemia agents
bisoxatin: it may increase the risk of methemoglobinemia agents
bisoxatin: it may increase the risk of methemoglobinemia agents
tinidazole has the potential to reduce the rate of excretion of bisoxatin, potentially leading to an elevation in level of serum
bisoxatin leads to a reduction in the rate of excretion of eucalyptus oil which leads to increased level of serum
cefpirome leads to a reduction in the rate of excretion of bisoxatin which leads to increased level of serum
bisoxatin leads to a reduction in the rate of excretion of chromous sulfate, which leads to an increased level of serum
bisoxatin leads to a reduction in the rate of excretion of potassium acetate, which leads to an increased level of serum
bisoxatin leads to a reduction in the rate of excretion of potassium perchlorate, which leads to an increased level of serum
bisoxatin: it may decrease the excretion rate of iothalamic acid
bisoxatin: it may decrease the excretion rate of isepamicin
bisoxatin: it may decrease the therapeutic efficacy of dextropropoxyphene
bisoxatin: it may increase the risk or severity of QTc prolongation agents
bisoxatin: it may increase the risk or severity of QTc prolongation agents
bisoxatin: it may increase the risk or severity of QTc prolongation agents
bisoxatin: it may increase the risk or severity of QTc prolongation agents
bisoxatin: it may increase the risk or severity of QTc prolongation agents
bisoxatin may decrease the excretion rate of almasilate, leading to higher serum levels
It may diminish the metabolism when combined with Choline esters
It may diminish the metabolism when combined with Choline esters
It may diminish the metabolism when combined with Choline esters
It may diminish the metabolism when combined with Choline esters
Action and Spectrum
It is not understood how bisoxatin works as a stimulant and how it controls the flow of water and ions in the body.
Frequency not defined
Diarrhoea
Nausea
Vomiting
Pain in the abdomen
Black Box Warning
Not available
Contraindication/Caution:
Contraindication:
Allergic to bisoxatin
Faecal perforation
Intestinal obstruction
Pregnancy consideration:
US FDA pregnancy category: not assigned
Lactation:
Data not established
Pregnancy category:
Category A: Studies that were well-controlled and met expectations revealed no risk to the foetus `in either the first or second trimester.
Category B: There were a lack of studies on pregnant women and no evidence of risk to the foetus in animal experiments.
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.
Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.
Category N: There is no data available for the drug under this category
Pharmacology
It is not understood how bisoxatin works as a stimulant and how it controls the flow of water and ions in the body.
Pharmacodynamics
It is a laxative that speeds up the intestinal contractions. It prevents the intestine from absorbing water and minerals. As a result, the stool becomes softer and bulkier, and it moves through the intestines more quickly.
Pharmacokinetics
Absorption
Maximum time of absorption:4 hours
Distribution
Not available
Metabolism
It is metabolised into its salt form glucuronide
Elimination/Excretion
Rate of excretion is 48 to 72 hours.Only trace amounts of drug is eliminated.
Administration
It is administered in the form of tablets at night time.
Patient information leaflet
Generic Name: bisoxatin
Why do we use bisoxatin?
It is used as a laxative and it stimulates the bowel movements by inhibiting the reabsorption of ions and water in the large intestine, thereby leading to increase in the intestinal contractions.
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