Anthropometric Measurements as Predictors of Low Birth Weight Among Tanzanian Neonates: A Hospital-Based Study
November 7, 2025
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Brand Name :
Maxipime
Synonyms :
cefpirome
Class :
Cephalosporin antibiotics
Brand Name :
Maxipime
Synonyms :
cefpirome
Class :
Cephalosporin antibiotics
Dosage forms and strengths Â
Injection; powder; for solutionÂ
1 gramÂ
Indicated for susceptible infections
The suggested dose is 1 to 2 grams intravenously two times a day
Not indicatedÂ
Refer adult dosingÂ
By competing with acidic (anionic) drugs for renal clearance, cefpirome will raise the amount of probenecid
it may diminish the excretion rate when combined with estradiol valerate resulting in a greater serum level
When cefpirome is used together with piroxicam, this leads to increased risk or seriousness of nephrotoxicity
When cefmenoxime is used together with cefpirome, this leads to enhanced risk or seriousness of nephrotoxicity
When cefpirome is used together with proglumetacin, this leads to enhanced risk or seriousness of nephrotoxicity
When cefpirome is used together with benoxaprofen, this leads to enhanced risk or seriousness of nephrotoxicity
cefpirome leads to a reduction in the rate of excretion of eucalyptus oil which leads to increased level of serum
cefpirome leads to a reduction in the rate of excretion of pentaerythritol tetranitrate, which leads to an increased level of serum
cefpirome leads to a reduction in the rate of excretion of potassium acetate, which leads to an increased level of serum
cefpirome leads to a reduction in the rate of excretion of potassium perchlorate, which leads to an increased level of serum
cefpirome leads to a reduction in the rate of excretion of nitric oxide, which leads to an increased level of serum
When cefpirome is used together with difenpiramide, this leads to enhanced risk or seriousness of nephrotoxicity
cefpirome: it may decrease the excretion rate of isepamicin
cefpirome might lead to a reduction in the rate of excretion of telavancin, potentially leading to elevated levels of serum
cefpirome may decrease the excretion rate of almasilate, leading to higher serum levels
cefpirome leads to a reduction in the rate of excretion of abacavir which leads to increased level of serum
cefpirome leads to a reduction in the rate of excretion of acetaminophen which leads to increased level of serum
cefpirome leads to a reduction in the rate of excretion of aclidinium which leads to increased level of serum
cefpirome leads to a reduction in the rate of excretion of aldesleukin which leads to increased level of serum
cefpirome leads to a reduction in the rate of excretion of allopurinol which leads to increased level of serum
cefpirome leads to a reduction in the rate of excretion of almasilate which leads to increased level of serum
cefpirome leads to a reduction in the rate of excretion of almotriptan which leads to increased level of serum
cefpirome leads to a reduction in the rate of excretion of alogliptin which leads to increased level of serum
cefpirome leads to a reduction in the rate of excretion of alprazolam which leads to increased level of serum
cefpirome leads to a reduction in the rate of excretion of amantadine which leads to increased level of serum
cefpirome leads to a reduction in the rate of excretion of amitriptyline which leads to increased level of serum
cefpirome leads to a reduction in the rate of excretion of ammonium chloride which leads to increased level of serum
cefpirome leads to a reduction in the rate of excretion of amoxicillin which leads to increased level of serum
cefpirome leads to a reduction in the rate of excretion of amphetamine which leads to increased level of serum
cefpirome leads to a reduction in the rate of excretion of ampicillin which leads to increased level of serum
cefpirome leads to a reduction in the rate of excretion of amrinone which leads to increased level of serum
cefpirome leads to a reduction in the rate of excretion of ancestim which leads to increased level of serum
cefpirome leads to a reduction in the rate of excretion of apalutamide which leads to increased level of serum
cefpirome leads to a reduction in the rate of excretion of apremilast which leads to increased level of serum
cefpirome leads to a reduction in the rate of excretion of arformoterol which leads to increased level of serum
cefpirome leads to a reduction in the rate of excretion of arsenic trioxide which leads to increased level of serum
cefpirome leads to a reduction in the rate of excretion of atomoxetine which leads to increased level of serum
cefpirome leads to a reduction in the rate of excretion of azacitidine which leads to increased level of serum
cefpirome leads to a reduction in the rate of excretion of azathioprine which leads to increased level of serum
cefpirome leads to a reduction in the rate of excretion of azelaic acid which leads to increased level of serum
cefpirome leads to a reduction in the rate of excretion of baclofen which leads to increased level of serum
cefpirome leads to a reduction in the rate of excretion of baricitinib which leads to increased level of serum
cefpirome leads to a reduction in the rate of excretion of benzatropine which leads to increased level of serum
cefpirome leads to a reduction in the rate of excretion of bepotastine which leads to increased level of serum
cefpirome leads to a reduction in the rate of excretion of bicisate which leads to increased level of serum
cefpirome leads to a reduction in the rate of excretion of bisoprolol which leads to increased level of serum
cefpirome leads to a reduction in the rate of excretion of bisoxatin which leads to increased level of serum
cefpirome leads to a reduction in the rate of excretion of bleomycin which leads to increased level of serum
cefpirome leads to a reduction in the rate of excretion of brivaracetam which leads to increased level of serum
cefpirome leads to a reduction in the rate of excretion of bromazepam which leads to increased level of serum
cefpirome leads to a reduction in the rate of excretion of budesonide which leads to increased level of serum
cefpirome leads to a reduction in the rate of excretion of bupropion which leads to increased level of serum
cefpirome leads to a reduction in the rate of excretion of buspirone which leads to increased level of serum
cefpirome leads to a reduction in the rate of excretion of butabarbital which leads to increased level of serum
cefpirome leads to a reduction in the rate of excretion of canagliflozin which leads to increased level of serum
cefpirome leads to a reduction in the rate of excretion of capreomycin which leads to increased level of serum
cefpirome leads to a reduction in the rate of excretion of carbamazepine which leads to increased level of serum
cefpirome leads to a reduction in the rate of excretion of carbidopa which leads to increased level of serum
cefpirome leads to a reduction in the rate of excretion of carmustine which leads to increased level of serum
when both drugs are combined, there may be an increased risk of adverse effects 
Actions and Spectrum:Â
Action:Â Â
Cefpirome interferes with the bacterial cell wall synthesis’s last stage by attaching to penicillin-binding proteins. PBPs are enzymes involved in the cross-linking of peptidoglycan chains in the bacterial cell wall. By inhibiting these enzymes, cefpirome weakens the bacterial cell wall, leading to cell lysis and eventual death of the bacteria.Â
Spectrum:Â
Gram-positive bacteria: Like Streptococcus pyogenes, Streptococcus pneumoniae, Staphylococcus aureus.Â
Gram-negative bacteria: Including Escherichia coli, Klebsiella pneumoniae, Enterobacter species, Haemophilus influenzae, Proteus mirabilis, Pseudomonas aeruginosa, and other Enterobacteriaceae.Â
Frequency not defined Â
DiarrheaÂ
FeverÂ
HeadacheÂ
VomitingÂ
NauseaÂ
ItchingÂ
RashÂ
Black Box Warning:Â Â
None
Contraindication/Caution:Â Â
Hypersensitivity: Individuals with a known hypersensitivity or allergic reaction to cefpirome, other cephalosporins, penicillins, or other beta-lactam antibiotics should avoid its use. Cross-reactivity between cephalosporins and penicillins may occur in some cases.Â
History of Severe Allergic Reactions: Patients with a history of severe allergic reactions to any beta-lactam antibiotics, including cephalosporins, should avoid cefpirome due to the potential risk of severe allergic reactions.Â
Colitis or Gastrointestinal Diseases: cefpirome may exacerbate pre-existing colitis or gastrointestinal diseases like Clostridium difficile-associated diarrhea. It’s crucial to evaluate the risks versus benefits in such cases before using this antibiotic.Â
Renal Impairment: Individuals with kidney disease may require dosage adjustment or close monitoring while using cefpirome. In severe cases of renal dysfunction or kidney failure, use may be contraindicated.Â
Pregnancy and Breastfeeding: The safety of cefpirome during pregnancy or breastfeeding hasn’t been firmly established. It should be used in pregnant or breastfeeding individuals only if the benefits outweigh the potential risks and under the supervision of a healthcare professional.Â
Pregnancy warnings:    Â
Pregnancy category: N/AÂ
Lactation: Excreted into human milk is unknownÂ
Pregnancy Categories:        Â
Category A: Studies that were well-controlled and met expectations revealed no risk to the fetus in either the first or second trimester.Â
Category B: There were a lack of studies on pregnant women and no evidence of risk to the fetus in animal experiments.  Â
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.   Â
Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.  Â
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.   Â
Category N: There is no data available for the drug under this category
Pharmacology: Cefpirome is a fourth-generation cephalosporin antibiotic with a broad spectrum of activity against various bacteria.Â
Pharmacodynamics:Â Â
Cefpirome exerts its antibacterial effects by inhibiting bacterial cell wall synthesis. It binds to penicillin-binding proteins (PBPs), particularly PBP-3, which are enzymes involved in the final steps of bacterial cell wall formation. This binding disrupts the cross-linking of peptidoglycan chains, reducing the strength of the bacterial cell wall, which causes cell lysis and ultimately bacterial death.Â
Pharmacokinetics:Â
AbsorptionÂ
Cefpirome is primarily administered intravenously (IV). When given via IV infusion, the drug achieves high and rapid concentrations in the bloodstream.Â
DistributionÂ
After entering the bloodstream, cefpirome distributes widely throughout the body’s tissues and fluids, including the lungs, skin, bones, and some other organs. It can penetrate various tissues to reach the site of infection.Â
MetabolismÂ
Cefpirome is not significantly metabolized in the body. Cephalosporins, in general, undergo minimal metabolism in humans.Â
Excretion and EliminationÂ
The primary route of elimination for cefpirome is through the kidneys. It is mostly eliminated unchanged in the urine. A small amount may be excreted in the feces and bile.Â
Administration: Â
The dosage of cefpirome can vary based on the severity of the infection, the patient’s age, weight, renal function, and other factors.Â
It is usually administered intravenously (IV) in a hospital or clinical setting by a healthcare professional.Â
Patient information leafletÂ
Generic Name: cefpiromeÂ
Why do we use cefpirome? Â
Cefpirome is effective against a wide range of bacterial infections caused by susceptible strains, including serious respiratory tract infections, soft tissues, bones & joints, urinary tract infections, abdominal infections & septicemia.Â
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