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Brand Name :
Tybost
Synonyms :
cobicistat
Class :
CYP450 Inhibitors
Brand Name :
Tybost
Synonyms :
cobicistat
Class :
CYP450 Inhibitors
Dosage forms & Strengths:Â
TabletÂ
150 mgÂ
Dosage forms & Strengths:Â
TabletÂ
150 mgÂ
cobicistat: they may diminish the serum concentration of hormonal contraceptives
cobicistat: they may diminish the serum concentration of hormonal contraceptives
cobicistat: they may diminish the serum concentration of hormonal contraceptives
cobicistat: they may diminish the serum concentration of hormonal contraceptives
It may enhance the effect when combined with irinotecan liposomal by affecting CYP3A4 metabolism
cobicistat: they may enhance the serum concentration of rifabutin
when both drugs are combined, there may be an increased risk of adverse effects 
may enhance the serum concentration of CYP3A4 Inhibitors
may diminish the concentration of serum when combined with cobicistat
may diminish the serum concentration of primidone
It may diminish the effect when combined with phenobarbital by affecting the intestinal/hepatic enzyme CYP3A4
may enhance the concentration of serum when combined with salmeterol
nafcillin will decrease the effect of action of cobicistat by affecting enzyme CYP3A4 metabolism.
when both drugs are combined, there may be an increased effect of cabozantinib by affecting hepatic or intestinal enzyme cyp3a4 metabolism  
when both drugs are combined, there may be an increased level of serum concentration of alpelisib   
the effect of cobicistat is increased by lorlatinib, by altering intestinal or hepatic CYP3A4 enzyme metabolism
cobicistat increases the effect of lapatinib by altering the intestinal or hepatic CYP3A4 enzyme metabolism
CYP3A strong enhancers of the small intestine may reduce the bioavailability of cobicistat 
it increases the effect or level of ruxolitinib by altering the intestinal or hepatic CYP3A4 enzyme metabolism conivaptan
may increase the level of effectiveness through P-glycoprotein MDR1 efflux transporter
may enhance the serum concentration of elbasvir/grazoprevir
rifampin: they may diminish the serum concentration of cobicistat
Could potentially lead to a reduction in the concentration serum of hormonal contraceptives
Could potentially lead to a reduction in the concentration serum of hormonal contraceptives
Could potentially lead to a reduction in the concentration serum of hormonal contraceptives
It may enhance the levels when combined with tamsulosin by affecting CYP3A4 metabolism
When alprazolam and cobicistat is used together, this leads to reduction in the alprazolam’s metabolism
When encainide is used together with cobicistat, this leads to a reduction in the encainide’s metabolism
when both drugs combine cobicistat will increase effect of ifosfamide by affecting the enzyme CYP3A4 metabolism.
has a synergistic effect over brentuximab vedotin, by showing altered intestinal/hepatic CYP3A4 enzyme metabolism
may increase serum level of docetaxel
May increase plasma concentration and therapeutic effects of other antiretroviral drugs
May increase plasma concentration and therapeutic effects of other antiretroviral drugs
it enhances by affecting the hepatic enzyme CYP2C9 metabolism
the rate of metabolism of dydrogesterone may be reduced
When cobicistat is used together with oliceridine, this leads to enhanced concentration serum of oliceridine
Could potentially lead to a reduction in the concentration serum of hormonal contraceptives
Could potentially lead to a reduction in the concentration serum of hormonal contraceptives
cobicistat, when taken with ixazomib, alters the intestinal/hepatic CYP3A4 enzyme metabolism
it decreases the concentration of hormonal contraceptives in serum
>10%:Â
Ocular icterusÂ
NauseaÂ
1-10%:Â
RashÂ
GlycosuriaÂ
RBCs in urineÂ
<2%:Â
VomitingÂ
DiarrheaÂ
HeadacheÂ
DepressionÂ
Nephropathy Â
InsomniaÂ
Abnormal dreamsÂ
FatigueÂ
RhabdomyolysisÂ
Cobicistat is contraindicated in patients hypersensitive to the active ingredient.Â
Pregnancy consideration:Â Â
Cobicistat should not be administered with darunavir or atazanavir during pregnancy.Â
Breastfeeding warnings:Â Â
The presence of cobicistat in breast milk is unknown.Â
Pregnancy category:Â
Patient information leafletÂ
Generic Name: cobicistatÂ
Pronounced: cobicistatÂ
Why do we use cobicistat?Â
Cobicistat belongs to the category of CYP450 inhibitors. It helps as a pharmacokinetic enhancer for HIV treatment.
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