- May 6, 2022
- Newsletter
- 617-430-5616
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Brand Name :
Myocet, Adriamycin, Caelyx, Rubex
Synonyms :
Class :
Antineoplastic agents: antibiotics & cytotoxics
DOSAGE FORMS & STRENGTHS
Injectable solution
5 mg/ml
Powder injection
20 mg
Acute lymphoblastic leukemia:
100 mg/m2 per day IV in combination with cytarabine for 77 days first course, for 5 days subsequent courses
25 mg/m2 IV once weekly for 4 weeks cycle in combination with vincristine, prednisone, and asparaginase
Acute myeloid leukemia:
20 mg/m2 IV per day on days 0 to 4 and 10 to 14 in combination with etoposide, cytarabine, thioguanine, and dexamethasone
Acute promyelocytic leukemia:
50 mg/m2 IV on days 3, 4, 5, and 6 in combination with cytarabine
Dose adjustment for kidney impairment:
Administer 50% of normal dose if Scr > 3 mg/dl
Dose adjustment for hepatic impairment:
Administer 75 % of the dose for serum bilirubin 1.2 to 3 mg/dl
Administer 50% of the dose for serum bilirubin > 3 mg/dl
DOSAGE FORMS & STRENGTHS
Injectable solution
5 mg/ml
Powder injection
20 mg
Acute lymphoblastic leukemia:
Children and Adolescents:
Note: Monitor for cardiac distress, and renal and hepatic function after each dose, adjust the dose accordingly
Induction dose: 25 mg/m2 IV per dose once weekly for 4 weeks in combination with other chemotherapeutic agents
Extended induction dose: 25 mg/m2 IV once per day the day 1 in combination with other chemotherapeutic agents
Maintenance dose: 20 mg/m2 IV per day for 2 days over 24 hours with continuous infusion of a total of 40 mg/m2 in combination with other chemotherapeutic agents for a total of 5 cycles of 41 days
Adolescents > 15 years: 50 mg/m2 IV per dose on days 1, 2, and 3 and 30 mg/m2 IV on days 15 and 16 in combination with other chemotherapeutic drugs
Acute lymphoblastic leukemia:
Children and Adolescents: 25 mg/m2 IV per dose on days 1, 8, 15, and 22 in combination with intrathecal methotrexate and cytarabine, and another chemotherapeutic drug
Infants and Children < 3 years: 0.67 mg/kg per day as a continuous IV infusion over 96 hours for total of 2.68 mg/kg dose
Dose adjustment for kidney impairment:
For infants, children, and adolescents, all patients who are on hemodialysis or CrCl < 30 ml/minute: administer 50% of the dose
Dose adjustment for hepatic impairment in all patients:
Administer 75% of the dose for serum bilirubin 1.2 to 3 mg/dL
Administer 50% of the dose for serum bilirubin >3 mg/dL
Avoid the use of the drug for serum bilirubin > 5 mg/dL
Refer to adult dosing
may enhance the immunosuppressive effect of immunosuppressants
may diminish therapeutic effects of the vaccine
may enhance the immunosuppressive effect of immunosuppressants
may enhance the immunosuppressive effect of immunosuppressants
immunosuppressants such as doxorubicin may enhance the immunosuppressive effect of another drug
immunosuppressants such as doxorubicin may enhance the immunosuppressive effect of another drug
may increase the serum concentration and adverse effects of daunorubicin by inhibiting BCRP
anthracyclines may decrease the serum concentration of digoxin
increase serum level of daunorubicin by P-glycoprotein efflux transporter
increases serum level of daunorubicin by P-glycoprotein efflux transporter
influenza virus vaccine trivalent
decreases therapeutic effects of influenza vaccine
increase serum level of daunorubicin by P-glycoprotein efflux transporter
interaction increases toxic effects of daunorubicin
interaction increases toxic effects of daunorubicin
increase serum level of daunorubicin by P-glycoprotein efflux transporter
increases serum level of daunorubicin by P-glycoprotein efflux transporter
increases immunosuppressive effects and risk of serious infections
increase myelosuppressive effects by increasing serum concentration of daunorubicin
increase the therapeutic effect of daunorubicin by P-glycoprotein efflux transporter
increase the excretion and reduce the effects of daunorubicin
increase the therapeutic effect of daunorubicin by P-glycoprotein efflux transporter
may enhance immunosuppressive effects of daunorubicin
increase the therapeutic effect of daunorubicin by P-glycoprotein efflux transporter
increase cardiac toxicity risk
increase the therapeutic effect of daunorubicin by P-glycoprotein efflux transporter
may diminish therapeutic effects of the vaccine
may enhance bone marrow suppression
increase the therapeutic effect of daunorubicin by P-glycoprotein efflux transporter
increase the therapeutic effect of daunorubicin by P-glycoprotein efflux transporter
increase the therapeutic effect of daunorubicin by P-glycoprotein efflux transporter
enhance cardiac toxicity
may diminish the therapeutic effects of the vaccine
may enhance immunosuppressive effects of daunorubicin
increase the therapeutic effect of daunorubicin by P-glycoprotein efflux transporter
increase the therapeutic effect of daunorubicin by P-glycoprotein efflux transporter
decrease the metabolism of daunorubicin and increase serum levels
decrease the metabolism of daunorubicin and increase serum levels
increase the therapeutic effect of daunorubicin by P-glycoprotein efflux transporter
may enhance the risk of serious infections due to increased immunosuppressive effects
increase the therapeutic effect of daunorubicin by P-glycoprotein efflux transporter
decrease the metabolism of daunorubicin and increase serum levels
decrease the metabolism of daunorubicin and increase serum levels, also increase the therapeutic effect of daunorubicin by P-glycoprotein efflux transporter
increases bone marrow suppression
increases cardiac distress risk
increases immunosuppression
increase the therapeutic effect of daunorubicin by P-glycoprotein efflux transporter
increase the therapeutic effect of daunorubicin by P-glycoprotein efflux transporter
increase the therapeutic effect of daunorubicin by P-glycoprotein efflux transporter
increase the therapeutic effect of daunorubicin by P-glycoprotein efflux transporter
increase the therapeutic effect of daunorubicin by P-glycoprotein efflux transporter
increase the therapeutic effect of daunorubicin by P-glycoprotein efflux transporter
increase the therapeutic effect of daunorubicin by P-glycoprotein efflux transporter
increase the therapeutic effect of daunorubicin by P-glycoprotein efflux transporter
increase the therapeutic effect of daunorubicin by P-glycoprotein efflux transporter
increase the therapeutic effect of daunorubicin by P-glycoprotein efflux transporter
increase the therapeutic effect of daunorubicin by P-glycoprotein efflux transporter
may enhance the risk of serious infections due to increased immunosuppressive effects
may enhance the risk of serious infections due to increased immunosuppressive effects
may enhance the adverse effects such as bone marrow suppression
increases the effects of daunorubicin by inhibiting BCRP transport
increases the effects of daunorubicin by inhibiting BCRP transport
immunosuppressive drugs may reduce the therapeutic effects of pidotimod
increase the therapeutic effect of daunorubicin by P-glycoprotein efflux transporter
may enhance the adverse effects such as bone marrow suppression
increase the therapeutic effect of daunorubicin by P-glycoprotein efflux transporter
increase the therapeutic effect of daunorubicin by P-glycoprotein efflux transporter
increases the effects of daunorubicin by inhibiting BCRP transport
increase the therapeutic effect of daunorubicin by P-glycoprotein efflux transporter
increase the therapeutic effect of daunorubicin by P-glycoprotein efflux transporter
increases the effects of daunorubicin by inhibiting BCRP transport
increase the therapeutic effect of daunorubicin by P-glycoprotein efflux transporter
increases immunosuppressive effects and increases the risk of serious infection
may diminish the therapeutic effects of sipuleucel-T
increases the effects of daunorubicin by inhibiting BCRP transport
increase the therapeutic effect of daunorubicin by P-glycoprotein efflux transporter
increase the therapeutic effect of daunorubicin by P-glycoprotein efflux transporter
increases the effects of daunorubicin by inhibiting BCRP transport
increase bone marrow suppression
increase the therapeutic effect of daunorubicin by P-glycoprotein efflux transporter
increase the therapeutic effect of daunorubicin by P-glycoprotein efflux transporter
increase the therapeutic effect of daunorubicin by P-glycoprotein efflux transporter
increase the therapeutic effect of daunorubicin by P-glycoprotein efflux transporter
It may enhance the effect when combined with tafamidis meglumine
when both drugs are combined, there may be a decreased metabolism of etoposide
when both the drugs are combined, the risk or severity of adverse effects increases
when both drugs are combined, there may be an increased risk or severity of adverse effects
when both drugs are combined, there may be an increased risk or severity of adverse effects
when both drugs are combined, there may be an increased risk or severity of adverse effects
may increase the risk of cardiotoxicity
Frequency defined:
>10%:
ECG abnormality
Ventricular premature contractions
Alopecia
Nausea
Vomiting
Weight loss
Mucositis
Anorexia
Myelosuppression
Pulmonary fibrosis
1% to 10%
Discoloration of sweat
Hyperuricemia
Diarrhea
Gastrointestinal ulcer
Discoloration of saliva
<1%
Anaphylactoid
Cardiac failure
Cardiac arrhythmia
Hepatitis
Increased serum bilirubin
Infertility
Nail banding
Pregnancy: Daunorubicin falls under the pregnancy category D. daunorubicin can cross the placenta and can cause fetal harm.
Lactation: excretion of daunorubicin in breast milk is unknown
Pregnancy category:
Daunorubicin is an anti-cancer agent used to treat leukemia.
Tell your physician if you have any side effects like chills, fever, tiredness, easy bruising, or unusual bleeding.
Do not take daunorubicin if you are allergic to it, and inform your doctor if you have any previous allergies.
Daunorubicin is harmful to the ingrowing fetus.
Inform the doctor about your pregnancy or plan of conception.
The pregnancy should be planned three months after the last dose of daunorubicin.
Both men and women should opt for effective birth control methods during the treatment.
The skin should not get exposed to this drug. If it encounters skin, rinse and wash off with soap.
If you miss a dose, ask your physician to reschedule it.
Overdose shall not occur as the medical professional administers it.
Keep the medication away from children, and do not share your medicines with others.