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Brand Name :
solopose
Synonyms :
etizolam
Class :
Anti-Anxiety agent
Brand Name :
solopose
Synonyms :
etizolam
Class :
Anti-Anxiety agent
Dosage forms and strengths Â
Tablet Â
0.5 mgÂ
In vivo data suggests taking 0.5 mg orally two times a day
Not indicatedÂ
Refer adult dosingÂ
When agomelatine is used together with etizolam, this leads to enhanced risk or seriousness of CNS depression
When alimemazine is used together with etizolam, this leads to enhanced risk or seriousness of CNS depression
When almotriptan is used together with etizolam, this leads to enhanced risk or seriousness of CNS depression
When alosetron is used together with etizolam, this leads to enhanced risk or seriousness of CNS depression
When alprazolam is used together with etizolam, this leads to enhanced risk or seriousness of CNS depression
When amisulpride is used together with etizolam, this leads to enhanced risk or seriousness of CNS depression
When amitriptyline is used together with etizolam, this leads to enhanced risk or seriousness of CNS depression
When amobarbital is used together with etizolam, this leads to enhanced risk or seriousness of CNS depression
When amoxapine is used together with etizolam, this leads to enhanced risk or seriousness of CNS depression
When apomorphine is used together with etizolam, this leads to enhanced risk or seriousness of CNS depression
When articaine is used together with etizolam, this leads to enhanced risk or seriousness of CNS depression
When asenapine is used together with etizolam, this leads to enhanced risk or seriousness of CNS depression
When atracurium is used together with etizolam, this leads to enhanced risk or seriousness of CNS depression
When benperidol is used together with etizolam, this leads to enhanced risk or seriousness of CNS depression
When benzocaine is used together with etizolam, this leads to enhanced risk or seriousness of CNS depression
When benzphetamine is used together with etizolam, this leads to enhanced risk or seriousness of CNS depression
When benzyl alcohol is used together with etizolam, this leads to enhanced risk or seriousness of CNS depression
When brexanolone is used together with etizolam, this leads to enhanced risk or seriousness of CNS depression
When brexpiprazole is used together with etizolam, this leads to enhanced risk or seriousness of CNS depression
When brivaracetam is used together with etizolam, this leads to enhanced risk or seriousness of CNS depression
When bromazepam is used together with etizolam, this leads to enhanced risk or seriousness of CNS depression
When bromocriptine is used together with etizolam, this leads to enhanced risk or seriousness of CNS depression
When brompheniramine is used together with etizolam, this leads to enhanced risk or seriousness of CNS depression
When bupivacaine is used together with etizolam, this leads to enhanced risk or seriousness of CNS depression
When bupropion is used together with etizolam, this leads to enhanced risk or seriousness of CNS depression
When buspirone is used together with etizolam, this leads to enhanced risk or seriousness of CNS depression
When butabarbital is used together with etizolam, this leads to enhanced risk or seriousness of CNS depression
When butalbital is used together with etizolam, this leads to enhanced risk or seriousness of CNS depression
When butriptyline is used together with etizolam, this leads to enhanced risk or seriousness of CNS depression
When cabergoline is used together with etizolam, this leads to enhanced risk or seriousness of CNS depression
When carbinoxamine is used together with etizolam, this leads to enhanced risk or seriousness of CNS depression
When cariprazine is used together with etizolam, this leads to enhanced risk or seriousness of CNS depression
When cetirizine is used together with etizolam, this leads to enhanced risk or seriousness of CNS depression
When chlordiazepoxide is used together with etizolam, this leads to enhanced risk or seriousness of CNS depression
When chloroprocaine is used together with etizolam, this leads to enhanced risk or seriousness of CNS depression
When chlorpheniramine is used together with etizolam, this leads to enhanced risk or seriousness of CNS depression
When chlorpromazine is used together with etizolam, this leads to enhanced risk or seriousness of CNS depression
When chlorprothixene is used together with etizolam, this leads to enhanced risk or seriousness of CNS depression
When chlorzoxazone is used together with etizolam, this leads to enhanced risk or seriousness of CNS depression
Actions and Spectrum:Â
Anxiolytic Action: etizolam acts as an anxiolytic agent, meaning it helps reduce anxiety and panic disorders. It does so by binding to gamma-aminobutyric acid (GABA) receptors in the brain. This binding increases GABA’s inhibitory actions, a neurotransmitter that reduces neuronal activity. This, in turn, leads to a calming effect, reducing feelings of anxiety and promoting relaxation.Â
Sedative-Hypnotic Action: etizolam also has sedative and hypnotic effects, which make it effective in treating insomnia and sleep disorders. It helps induce sleep and maintain a regular sleep pattern by slowing down brain activity and promoting a sense of drowsiness.Â
Â
Frequency not defined Â
Muscle weaknessÂ
Muscle coordination impairedÂ
HeadacheÂ
FaintingÂ
DrowsinessÂ
ConfusionÂ
Black Box Warning:Â Â
None
Contraindication/Caution:Â Â
Hypersensitivity: Individuals who have a known hypersensitivity or allergy to etizolam or related compounds should not use this medication.Â
Respiratory Depression: etizolam can suppress the respiratory system, so it should be avoided in individuals with a history of respiratory depression, severe respiratory disorders, or obstructive sleep apnea.Â
Liver Impairment: Patients with severe liver impairment should use etizolam with caution, as it may be metabolized more slowly and lead to an increased risk of adverse effects.Â
Pregnancy and Breastfeeding: etizolam should not be used by pregnant women, as it may be harmful to the developing fetus. Additionally, it may enter breast milk and harm a baby who is being breastfed.Â
Children and Adolescents: etizolam is generally not recommended for use in children and adolescents, as its safety and efficacy in this age group have not been well-established.Â
Pregnancy warnings:    Â
Pregnancy category: N/AÂ
Lactation: Excreted into human milk is unknownÂ
Pregnancy Categories:        Â
Category A: Studies that were well-controlled and met expectations revealed no risk to the fetus in either the first or second trimester.Â
Category B: There were a lack of studies on pregnant women and no evidence of risk to the fetus in animal experiments.  Â
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.   Â
Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.  Â
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.   Â
Category N: There is no data available for the drug under this category
Pharmacology: etizolam is a thienodiazepine derivative that is chemically related to benzodiazepines. It is primarily used for its anxiolytic (anxiety-reducing) and sedative effects.Â
Pharmacodynamics:Â Â
Like benzodiazepines, etizolam acts on the gamma-aminobutyric acid (GABA) neurotransmitter system. It enhances the activity of GABA, by binding to GABA-A receptors. This leads to an increase in the inhibitory effect of GABA, resulting in reduced neuronal excitability and calming of the brain. Â
Pharmacokinetics:Â
AbsorptionÂ
etizolam is usually administered orally, and it is rapidly absorbed from the gastrointestinal tract.Â
Its bioavailability is relatively high, with a quick onset of action, typically within 30-60 minutes.Â
DistributionÂ
etizolam is lipophilic; it can distribute well into various tissues in the body, including the brain. Â
It binds to proteins in the bloodstream, primarily albumin. etizolam can easily cross the blood-brain barrier, which improves its psychoactive action.Â
MetabolismÂ
etizolam undergoes hepatic metabolism, primarily in the liver.Â
It is metabolized by enzymes, such as CYP3A4 and CYP2C19, into several active metabolites.Â
These metabolites contribute to the drug’s pharmacological effects.Â
Excretion and EliminationÂ
etizolam and its metabolites are primarily excreted through the urine.Â
The drug half-life of elimination is comparatively short, typically around 3-4 hours.Â
etizolam and its metabolites can be detected in urine for a few days after ingestion.Â
Administration: Â
The route of administration is oral.Â
The dosage form and frequency are determined by the healthcare professional based on the condition treated.Â
Patient information leafletÂ
Generic Name: etizolamÂ
Why do we use etizolam? Â
etizolam is primarily used to manage symptoms of anxiety disorders. It can assist in easing tense, restless, and anxious symptoms. However, it should only be used under the supervision of a qualified healthcare professional.Â
It may be prescribed to treat short-term insomnia, as it has sedative properties that can help induce sleep and improve sleep quality.Â
etizolam can be used in the short-term management of panic attacks or panic disorder, helping to alleviate the intense feelings of fear and panic.Â
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