The Navigation Model of Therapy: Why Awareness Changes Everything
November 16, 2025
Free CME credits
Both our subscription plans include Free CME/CPD AMA PRA Category 1 credits.
Brand Name :
Plendil
Synonyms :
felodipine
Class :
Calcium channel blockers and antihypertensives
Brand Name :
Plendil
Synonyms :
felodipine
Class :
Calcium channel blockers and antihypertensives
Dosage Forms & StrengthsÂ
Tablet extended release, Oral:Â
2.5 mgÂ
5 mgÂ
10 mgÂ
initial dose:
5
mg
Orally 
once a day
Maintenance dose: 10 mg orally once a day after 2 to 4 weeks of the initial dose
2.5 - 5
mg
Orally 
once a day
1 - 2
weeks
Dosage Forms & StrengthsÂ
Tablet extended release, Oral:Â
2.5 mgÂ
5 mgÂ
10 mgÂ
For children > 5 years:
2.5 - 5
mg
Orally 
once a day
1 - 2
weeks
Refer to adult dosingÂ
felodipine: they may diminish the serum concentration of CYP3A4 Inducers
felodipine: they may diminish the serum concentration of CYP3A4 Inducers
felodipine: they may diminish the serum concentration of CYP3A4 Inducers
felodipine: they may diminish the serum concentration of CYP3A4 Inducers
felodipine: they may diminish the serum concentration of CYP3A4 Inducers
It may enhance toxicity when combined with cholic acid by diminishing the elimination
CYP3A strong enhancers of the small intestine may reduce the bioavailability of felodipine
It may enhance the serum concentration when combined with CYP3A4 Inhibitors (Moderate)
It may enhance the serum concentration when combined with CYP3A4 Inhibitors (Moderate)
It may enhance the serum concentration when combined with CYP3A4 Inhibitors (Moderate)
It may enhance the serum concentration when combined with CYP3A4 Inhibitors (Moderate)
It may enhance the serum concentration when combined with CYP3A4 Inhibitors (Moderate)
It may diminish the effects when combined with metformin by pharmacodynamic antagonism
felodipine: they may enhance the serum concentration of CYP3A inhibitors
felodipine: they may enhance the serum concentration of CYP3A inhibitors
felodipine: they may enhance the serum concentration of CYP3A inhibitors
felodipine: they may enhance the serum concentration of CYP3A inhibitors
felodipine: they may enhance the serum concentration of CYP3A inhibitors
When acetohexamide is used together with felodipine, this lead to reduction in acetohexamide’s metabolism
the effect of felodipine is decreased by lorlatinib, by altering intestinal or hepatic CYP3A4 enzyme metabolism
relugolix/​estradiol/​norethindroneÂ
may increase the level of effectiveness through P-glycoprotein MDR1 efflux transporter
the risk of QTc prolongation may be increased
When felodipine is used together with oliceridine, this leads to reduction in oliceridine’s metabolism
reduction in bloop pressure is seen with carnosine when used in combination
Frequency defined:Â Â Â
>10%Â
Peripheral edemaÂ
Headache  Â
1% to 10%Â
FlushingÂ
Tachycardia   Â
<1% PostmarketingÂ
Abdominal painÂ
Acid regulationÂ
AnemiaÂ
BruiseÂ
Chest painÂ
Pregnancy consideration: Not enough studies are available for felodipine, therefore not recommended as initial therapy in pregnant women. Some adverse effects were reported in animal reproductive studies.Â
Lactation: excretion of felodipine in breast milk is not known. Â
Pregnancy category:Â
Patient information leafletÂ
Generic Name: FelodipineÂ
Pronounced: felodipine Â
Why do we use felodipine?Â
Felodipine is used for the treatment of hypertension and Chronic angina.Â
Both our subscription plans include Free CME/CPD AMA PRA Category 1 credits.
On course completion, you will receive a full-sized presentation quality digital certificate.
A dynamic medical simulation platform designed to train healthcare professionals and students to effectively run code situations through an immersive hands-on experience in a live, interactive 3D environment.
When you have your licenses, certificates and CMEs in one place, it's easier to track your career growth. You can easily share these with hospitals as well, using your medtigo app.
