Anthropometric Measurements as Predictors of Low Birth Weight Among Tanzanian Neonates: A Hospital-Based Study
November 7, 2025
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Brand Name :
N/A
Synonyms :
mofebutazone, mofebutazonum 
Class :
Anti-inflammatory, analgesics, & phenylbutazone derivative
Brand Name :
N/A
Synonyms :
mofebutazone, mofebutazonum 
Class :
Anti-inflammatory, analgesics, & phenylbutazone derivative
Adult dosing
Dosage forms and strengths
Tablet
300mg
Asthma (off label dosing) 
300 mg orally two times a day 5days
Off-label dosing
:
300
mg
Tablet
Orally 
twice a day
15
days
Data not available
Refer to adult dosing
an increase in the risk of adverse effects can be seen when acetylsalicylic acid is taken with mofebutazone
an increase in the risk of adverse effects can be seen when mofebutazone is taken with acemetacin
an increase in the risk of adverse effects can be seen when alclofenac is taken with mofebutazone
the excretory rate of allopurinol may be reduced when taken with mofebutazone that, results in increased serum levels of allopurinol
an increase in severity of hemorrhage and bleeding may be seen when mofebutazone is administered with alteplase
an increase in the severity of hypertension, kidney failure, or hyperkalemia may be seen when mofebutazone is administered with amiloride
the excretory rate of amantadine may be reduced when taken with mofebutazone, which results in increased serum levels of amantadine
an increase in severity of hemorrhage and bleeding may be seen when mofebutazone is administered with antithrombin III
an increase in the severity of hemorrhage and bleeding may be seen when mofebutazone is administered with ardeparin
the excretory rate of baricitinib may be reduced when taken with mofebutazone that, which results in increased serum levels of baricitinib
the excretory rate of benzatropine may be reduced when taken with mofebutazone that, which results in increased serum levels of benzatropine
an increase in the risk of bleeding can be seen when betrixaban is administered with mofebutazone
the therapeutic efficiency of bretylium can be reduced when taken with mofebutazone
an increase in risk of hypertension can be seen when buspirone is taken with mufebutazone
an increase in risk of hypertension can be seen when cannabidiol is taken with mufebutazone
the excretory rate of capreomycin may be reduced when taken with mofebutazone, which results in increased serum levels of capreomycin
an increase in the severity of hypertension, kidney failure, or hyperkalemia may be seen when mofebutazone is administered with captopril
the severity of nephrotoxicity can be enhanced when cefaclor is administered with mufebutazone
the excretory rate of carmustine may be reduced when taken with mofebutazone, resulting in increased serum levels of carmustine
the excretory rate of cefepime may be reduced when taken with mofebutazone, resulting in increased serum levels of cefepime
the excretory rate of cefuroxime may be reduced when taken with mofebutazone, resulting in increased serum levels of cefuroxime
the excretory rate of chloroquine may be reduced when taken with mofebutazone, resulting in increased serum levels of chloroquine
the protein binding efficiency of chlorpropamide may be reduced when taken with mofebutazone
the severity of nephrotoxicity can be enhanced when cidofovir is administered with mufebutazone
the protein binding efficiency of valproic acid may be reduced when taken with mofebutazone
the severity of hemorrhage and bleeding can be seen when mofebutazone is administered with urokinase
the severity of gastrointestinal bleeding can be enhanced when mofebutazone is administered with zoledronic acid
Actions and Spectrum:
Mofebutazone acts like coumarin anticoagulant and glucocorticoids and indomethacin via interacting with albumin in the plasma.
Adverse Reaction  Â
Frequency not defined
Data unavailable
Black Box Warning:
None
Contraindication/Caution: 
Not indicated
Pregnancy consideration:  
USFDA pregnancy category: N/A
Lactation:  
Data insufficient
Pregnancy category:  
Pharmacology:
Mofebutazone is used to treat muscular pain and pain in joints.
Pharmacodynamics: 
Mofebutazone inhibits cyclooxygenase (COX) enzymes by reducing the production of prostaglandins which contribute to inflammation, pain, and fever. It provides pain relief and lowers fever by acting on arachidonic acid.
Pharmacokinetics: 
Absorption
Rate and extent of absorption can vary with food.
Distribution
Well distributed throughout the body.
Metabolism
It undergoes metabolic pathways involve hydroxylation and conjugation reactions.
Excretion
The metabolites excreted by kidneys.
Administration:
The drug is taken orally.
Patient information leaflet 
Generic Name: mofebutazone
Why do we use mofebutazone? 
Mofebutazone is a nonsteroidal anti-inflammatory drug which help in reduction of inflammation and provides relief from mild to moderate pain and reduces fever.
It is commonly used in rheumatic diseases, postoperative pain, and acute gouty arthritis.
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