How Far Is Too Far? The Ethics of Mini Brain Research
December 11, 2025
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Brand Name :
Mogadon
Synonyms :
nitrazepam
Class :
Benzodiazepine
Brand Name :
Mogadon
Synonyms :
nitrazepam
Class :
Benzodiazepine
Dosage Forms & Strengths
Tablet
5 mg
10 mg
Take a dose of 5 to 10 mg orally one time daily before sleep, as required
Dosage Forms & Strengths
Tablet
5 mg
10 mg
For infants and children ≤30 kg:
Take a dose of 0.3 to 1 mg/kg/day orally in three equally divided doses before sleep
Refer to adult dosing
nitrazepam: they may increase the CNS depressant effect of CNS Depressants
nitrazepam: they may increase the CNS depressant effect of CNS Depressants
nitrazepam: they may increase the CNS depressant effect of CNS Depressants
nitrazepam: they may increase the CNS depressant effect of CNS Depressants
nitrazepam: they may increase the CNS depressant effect of CNS Depressants
may increase the level by affecting hepatic enzyme CYP3A4 metabolism
may increase the level by affecting hepatic enzyme CYP3A4 metabolism
may increase the level by affecting hepatic enzyme CYP3A4 metabolism
may increase the level by affecting hepatic enzyme CYP3A4 metabolism
may increase the level by affecting hepatic enzyme CYP3A4 metabolism
may decrease the level by affecting hepatic enzyme CYP3A4 metabolism
may decrease the level by affecting hepatic enzyme CYP3A4 metabolism
may decrease the level by affecting hepatic enzyme CYP3A4 metabolism
may decrease the level by affecting hepatic enzyme CYP3A4 metabolism
may decrease the level by affecting hepatic enzyme CYP3A4 metabolism
relugolix/estradiol/norethindrone
may increase the level by affecting hepatic enzyme CYP3A4 metabolism
may increase the level by affecting hepatic enzyme CYP3A4 metabolism
may increase the level by affecting hepatic enzyme CYP3A4 metabolism
may increase the level by affecting hepatic enzyme CYP3A4 metabolism
may increase the level by affecting hepatic enzyme CYP3A4 metabolism
may increase the level by affecting the hepatic enzyme CYP3A4 metabolism
may increase the level by affecting the hepatic enzyme CYP3A4 metabolism
may increase the level by affecting hepatic enzyme CYP3A4 metabolism
may increase the level by affecting hepatic enzyme CYP3A4 metabolism
may increase the level by affecting hepatic enzyme CYP3A4 metabolism
may decrease the level by affecting hepatic enzyme CYP3A4 metabolism
may decrease the level by affecting hepatic enzyme CYP3A4 metabolism
may decrease the level by affecting hepatic enzyme CYP3A4 metabolism
may decrease the level by affecting hepatic enzyme CYP3A4 metabolism
may decrease the level by affecting hepatic enzyme CYP3A4 metabolism
The potential for increased CNS depression risk or seriousness occurs when nitrazepam is used together with pipecuronium
May diminish the effects of pharmacodynamic antagonism
May diminish the effects of pharmacodynamic antagonism
May diminish the effects of pharmacodynamic antagonism
May diminish the effects of pharmacodynamic antagonism
May diminish the effects of pharmacodynamic antagonism
may decrease the levels by unspecified interaction mechanism
may decrease the levels by unspecified interaction mechanism
may decrease the levels by unspecified interaction mechanism
may decrease the levels by unspecified interaction mechanism
may decrease the levels by unspecified interaction mechanism
may have an increasingly adverse effect when combined with products containing botulinum toxin
may increase the risk of sedation
may increase the risk of sedation
may increase the risk of sedation
may increase the risk of sedation
may increase the risk of sedation
may enhances the effects of the other by pharmacodynamic synergism
may enhances the effects of the other by pharmacodynamic synergism
may enhances the effects of the other by pharmacodynamic synergism
may enhances the effects of the other by pharmacodynamic synergism
may enhances the effects of the other by pharmacodynamic synergism
may have an increased hepatotoxic effect when combined with nitrazepam
It may enhance the risk of adverse effects when combined with Anticonvulsants
Actions and Spectrum
nitrazepam has sedative-hypnotic action, which means it helps induce and maintain sleep. It enhances the inhibitory neurotransmitter gamma-aminobutyric acid (GABA) in the brain. GABA reduces the activity of certain neurons, making you feel calmer and more relaxed.
Frequency not defined
Hypotension
Leukopenia
Anaphylaxis
Nervous system
Abnormal dreams
Palpitations
Change in libido
Granulocytopenia
Depressed dreaming
Abnormality in thinking
Aggressive behavior
Emotional lability
Fatigue
Hallucination
Disorientation
Dizziness
Drug abuse
Dyspnea
Black Box Warning
None
Contraindication/Caution:
Contraindication:
Caution:
Pregnancy consideration:
Pregnancy category: N/A
Lactation: Excretion into human milk is unknown
Pregnancy Categories:
Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester.
Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.
Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.
Category N: There is no data available for the drug under this category.
Pharmacology
nitrazepam enhances the binding of GABA to its receptors, which increases the inhibitory effect of GABA on neurons.
GABA is a neurotransmitter that reduces neuronal excitability, leading to a calming and sedative effect.
Pharmacodynamics
nitrazepam has anticonvulsant properties and may be used as an adjunctive treatment for certain types of seizures and epilepsy.
This effect is related to its ability to stabilize neuronal activity and reduce the excessive excitability that can lead to seizures.
Pharmacokinetics
Absorption
nitrazepam is well absorbed from the gastrointestinal tract.
Distribution
nitrazepam is distributed throughout the body.
Metabolism
nitrazepam is primarily metabolized in the liver.
Elimination and excretion
nitrazepam are excreted through the kidneys.
Administration
nitrazepam is available in the form of tablets for oral intake.
Patient information leaflet
Generic Name: nitrazepam
Why do we use nitrazepam?
nitrazepam is indicated for the short-term treatment insomnia, a condition characterized by difficulty falling asleep.
nitrazepam may be used to treat generalized anxiety disorder and other anxiety-related conditions.
nitrazepam may be used as an adjunctive treatment for certain types of seizures or epilepsy.
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