Fame and Mortality: Evidence from a Retrospective Analysis of Singers
November 26, 2025
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Brand Name :
No Data Available.
Synonyms :
prazosin
Class :
Anti-hypertensives and Alpha-Blockers
Brand Name :
No Data Available.
Synonyms :
prazosin
Class :
Anti-hypertensives and Alpha-Blockers
Dosage Forms & StrengthsÂ
capsule
1mg
2mg
5mg
Initial:
1
mg
Orally
8 - 12
hrs
Maintenance: 6-15 mg once a day or divided 2 to 3 times a day alternatively
off-label
Initial:
0.5
mg
Orally
every 12 hrs
Maintenance: 2 mg orally 12 hours
Dosage Forms & StrengthsÂ
capsule
1mg
2mg
5mg
Off-label:
Initial: 0.05-0.1 mg/kg orally once a day
may decrease the diagnostic effect when combined with benzylpenicilloyl polylysine
may have an increased hypertensive effect when combined with alpha1-blockers
may increase the action of CNS depressants inducing CNS depression
may increase the action of CNS depressants inducing CNS depression
may increase the action of CNS depressants inducing CNS depression
may increase the action of CNS depressants inducing CNS depression
may increase the action of CNS depressants inducing CNS depression
may have an increased hypotensive effect when combined with calcium channel blockers
may have an increased hypotensive effect when combined with calcium channel blockers
may have an increased hypotensive effect when combined with calcium channel blockers
may have an increased hypotensive effect when combined with calcium channel blockers
may have an increased hypotensive effect when combined with calcium channel blockers
may enhance the antihypertensive effect of other alpha1-Blockers
may enhance the antihypertensive effect of other alpha1-Blockers
may enhance the antihypertensive effect of other alpha1-Blockers
may enhance the antihypertensive effect of other alpha1-Blockers
may enhance the antihypertensive effect of other alpha1-Blockers
may increase the hypertensive effect of Monoamine Oxidase inhibitors
may decrease the vasoconstriction effects
prazosin: they may increase the hypotensive effect when combined with antihypertensive agents
prazosin: they may increase the hypotensive effect when combined with antihypertensive agents
prazosin: they may increase the hypotensive effect when combined with antihypertensive agents
prazosin: they may increase the hypotensive effect when combined with antihypertensive agents
prazosin: they may increase the hypotensive effect when combined with antihypertensive agents
may decrease the vasoconstricting effect when combined with alpha-/beta-agonists
alpha1-Blockers may reduce the vasoconstricting effect of alpha-/Beta-agonist
may enhance the orthostatic hypotensive effect of alpha1-blockers
may enhance the orthostatic hypotensive effect of alpha1-blockers
may enhance the orthostatic hypotensive effect of alpha1-blockers
may enhance the orthostatic hypotensive effect of alpha1-blockers
may enhance the orthostatic hypotensive effect of alpha1-blockers
may enhance the hypotensive effect of calcium channel blockers
may enhance the hypotensive effect of calcium channel blockers
may enhance the hypotensive effect of calcium channel blockers
may enhance the hypotensive effect of calcium channel blockers
may enhance the hypotensive effect of calcium channel blockers
alpha1-Blockers may enhance the hypotensive effect of phosphodiesterase 5 Inhibitors
alpha1-Blockers may enhance the hypotensive effect of phosphodiesterase 5 Inhibitors
alpha1-Blockers may enhance the hypotensive effect of phosphodiesterase 5 Inhibitors
may decrease the constriction effects of alpha-1 agonist
may decrease the constriction effects of alpha-1 agonist
hydrocodone/​chlorpheniramine/​pseudoephedrineÂ
may decrease the vasoconstriction effects of alpha/beta agonists
may increase the bradycardia effect
may enhance the hypotensive effect of Alpha1-Blockers
may enhance the hypotensive effect of Alpha1-Blockers
may enhance the hypotensive effect of Alpha1-Blockers
may enhance the hypotensive effect of Alpha1-Blockers
may enhance the hypotensive effect of Alpha1-Blockers
acrivastine and pseudoephedrineÂ
may increase the vasoconstrictive effect of alpha/beta agonists
may increase the hypotensive effect of calcium channel blockers
may increase the hypotensive effect of calcium channel blockers
may enhance the orthostatic effect of beta blockers
may increase the effect of alpha1-blockers
may increase the effect of alpha1-blockers
may increase the effect of alpha1-blockers
may increase the effect of alpha1-blockers
may increase the effect of alpha1-blockers
may increase the effect of alpha1-blockers
may decrease the vasoconstricting effect of Alpha-/Beta-Agonists
may decrease the vasoconstricting effect when combined with alpha1-agonists
may decrease the vasoconstricting effect when combined with alpha1-agonists
bunazosin (Not available in the United States)
may decrease the vasoconstricting effect when combined with alpha1-agonists
may decrease the vasoconstricting effect when combined with alpha1-agonists
may decrease the vasoconstricting effect when combined with alpha1-agonists
may have an increased therapeutic effect when combined with alpha1-agonists
may increase the hypotensive effect of alpha1-blockers
may increase the hypotensive effect of alpha1-blockers
may increase the hypotensive effect of alpha1-blockers
may increase the hypotensive effect of alpha1-blockers
may increase the hypotensive effect of alpha1-blockers
Action:Â
Prazosin is a selective alpha-1 adrenergic receptor antagonist that works by blocking alpha-1 receptors on vascular smooth muscle. This leads to vasodilation, resulting in a decrease in peripheral vascular resistance and lowered blood pressure. Unlike non-selective alpha blockers, prazosin does not significantly affect heart rate. It also relaxes smooth muscle in the bladder neck and prostate, improving urine flow in conditions like benign prostatic hyperplasia (BPH).Â
Spectrum:Â
Prazosin is primarily used for the management of hypertension, especially in patients who do not tolerate other antihypertensives. It is also used in the treatment of benign prostatic hyperplasia (BPH) to relieve urinary symptoms. Additionally, prazosin has been found effective in managing post-traumatic stress disorder (PTSD)-related nightmares and sleep disturbances, making it useful in psychiatric settings. Occasionally, it may also be used off-label for Raynaud’s phenomenon or congestive heart failure, although these are less common indications.Â
Adverse drug reactions:
Frequency definedÂ
1-10%Â
DrowsinessÂ
Dizziness Â
Frequency Not Defined Â
EdemaÂ
Orthostatic hypotensionÂ
SyncopeÂ
FeverÂ
VomitingÂ
Abnormal liver function testsÂ
ImpotenceÂ
PancreatitisÂ
Urinary incontinenceÂ
RashÂ
Abdominal discomfort/painÂ
DiarrheaÂ
None
Contraindication:Â
Known hypersensitivityÂ
History of orthostatic hypotensionÂ
Caution:Â
Cardiovascular diseaseÂ
History of narcolepsyÂ
CNS depressionÂ
Pregnancy warnings:Â Â
AU TGA pregnancy category: B2
US FDA pregnancy category: C
Breastfeeding warnings:
The release of the drug into the human breastmilk is known
Pregnancy Categories:Â Â Â
Category A:Â Satisfactory and well-controlled studies show no risk to the fetus in the first or later trimester.
Category B:Â No evidence shown of risk to the fetus found in animal reproduction studies, and there are not enough studies on pregnant women
Category C:Â Adverse effects on the fetus found with evidence in animal reproduction studies and no adequate evidence for a result in humans must take care of potential risks in pregnant women
Category D:Â There is adequate data available with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits
Category X:Â Drugs listed in this category outweigh risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.
Category N:Â There is no data available for the drug under this category
Prazosin is a selective alpha-1 adrenergic receptor antagonist that exerts its effects by blocking alpha-1 receptors located on vascular smooth muscle. This blockade leads to vasodilation, resulting in a reduction in peripheral vascular resistance and lowered blood pressure without significantly increasing heart rate (reflex tachycardia). In the urinary tract, prazosin relaxes smooth muscle in the bladder neck and prostate, easing urinary flow in conditions like benign prostatic hyperplasia (BPH).Â
Pharmacokinetics:Â
AbsorptionÂ
Prazosin has an oral bioavailability ranging from 43% to 82% and begins to take effect approximately 2 hours after administration. Its peak plasma concentrations occur within 2 to 3 hours, with the peak therapeutic effect seen around 2 to 4 hours. The drug’s duration of action lasts between 10 to 24 hours.Â
DistributionÂ
Prazosin is highly protein-bound (about 97%).Â
MetabolismÂ
It undergoes extensive hepatic metabolism.Â
Excretion and EliminationÂ
It has an elimination half-life of 2 to 3 hours. Excretion occurs primarily through the feces via bile, while about 6% to 10% of the drug is excreted in the urine.Â
Prazosin is administered orally, typically in tablet form, and is usually taken two to three times daily depending on the prescribed regimen. Subsequent doses may be gradually increased based on the patient’s response and tolerance.Â
It can be taken with or without food but taking it with food may help minimize the risk of dizziness or lightheadedness.Â
Patient information leafletÂ
Generic Name: prazosin Â
Pronounced: Pra-zoh-sinÂ
Why do we use prazosin?Â
Prazosin is primarily used in the management of hypertension, where it helps lower blood pressure by relaxing blood vessels. It is also commonly used to treat benign prostatic hyperplasia (BPH), as it relaxes smooth muscle in the bladder neck and prostate, improving urinary flow. In psychiatric practice, prazosin is frequently prescribed for post-traumatic stress disorder (PTSD) to reduce nightmares and sleep disturbances. Additionally, it may be used off-label for conditions such as Raynaud’s phenomenon, pheochromocytoma-related hypertension, and congestive heart failure, although these are less common indications.Â
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