Microplastics and Misinformation: What Science Really Says
November 12, 2025
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Brand Name :
Soltamox
(United States) [Available]Synonyms :
Tamoxifen
Class :
Anticancer & Hormonal agents
Brand Name :
Soltamox
(United States) [Available]Synonyms :
Tamoxifen
Class :
Anticancer & Hormonal agents
Dosage forms and strength
Tablet
10 mg
20 mg
Adult
Take a dose of 20 mg orally one time daily up to 5 years
Dosage forms and strength
Tablet
10 mg
20 mg
Girls from 2 to 10 years old:
Take a dose of 20 mg orally one time daily up to one year
may enhance the Qtc prolonging effect
may diminish the serum concentrations of CYP2D6 inhibitors
they decrease the concentration of active metabolites of tamoxifen in serum
they decrease the concentration of active metabolites of tamoxifen in serum
they decrease the concentration of active metabolites of tamoxifen in serum
they decrease the concentration of active metabolites of tamoxifen in serum
they decrease the concentration of active metabolites of tamoxifen in serum
CYP3A strong enhancers of the small intestine may reduce the bioavailability of tamoxifen
may increase the level of effectiveness through P-glycoprotein MDR1 efflux transporter
tamoxifen decreases the concentration of anastrozole in serum
may decrease the serum concentration of tamoxifen by increasing CYP2D6 substrates
tamoxifen may decrease serum concentration of anastrozole
may decrease the serum concentration of tamoxifen by increasing CYP2D6 substrates
tamoxifen may enhance the toxic effects of chloroquine and the risk of retinal toxicity
may increase the serum concentration of tamoxifen
may diminish the diagnostic effects of fluoroestradiol
tamoxifen may enhance the toxic effects of chloroquine and the risk of retinal toxicity
may increase the serum concentration of tamoxifen
tamoxifen decreases the serum concentration of letrozole
interaction may enhance the hepatotoxic effects of mipomersen
may diminish the therapeutic effects of tamoxifen
may decrease the serum concentration of tamoxifen by increasing CYP2D6 substrates
may increase the serum concentration and toxic effects of tamoxifen
may enhance the serum concentration of tolbutamide by inducing CYP2C9 inhibitors
may increase the serum concentration of warfarin
It may enhance the effect when combined with cannabidiol by diminishing metabolism
tamoxifen increases the toxic or adverse effects of hydroxychloroquine
may have an increased thrombogenic effect when combined with c1 inhibitors
nafcillin will decrease the effect of action of tamoxifen by affecting enzyme CYP3A4 metabolism.
the effect of tamoxifen is decreased by lorlatinib, by altering intestinal or hepatic CYP3A4 enzyme metabolism
May reduce the serum concentration of letrozole
May reduce the serum concentration of anastrozole
may enhance the QTc-prolonging effect of Moxifloxacin
QT-prolongers increase the effect of QTc prolongation of haloperidol
may enhance the thrombogenic effect of immune globulin
may enhance the thrombogenic effect of immune globulin
may enhance the thrombogenic effect of immune globulin
may enhance the thrombogenic effect of immune globulin
may enhance the thrombogenic effect of immune globulin
may decrease the therapeutic effect of hyaluronidase
tamoxifen increases the hepatotoxicity of mipomersen
tamoxifen increases the toxic or adverse effects of chloroquine
It may enhance the risk of adverse effects when combined with dopamine receptors antagonists
It may enhance the risk of adverse effects when combined with dopamine receptors antagonists
they decrease the concentration of active metabolites of tamoxifen in serum
they decrease the concentration of active metabolites of tamoxifen in serum
they decrease the concentration of active metabolites of tamoxifen in serum
they decrease the concentration of active metabolites of tamoxifen in serum
they decrease the concentration of active metabolites of tamoxifen in serum
it decreases the concentration of tamoxifen in serum
estrogen receptor antagonists decrease diagnostic effect in fluoroestradiol F18
Actions and Spectrum:
Tamoxifen occupies estrogen receptors on hormone by positive breast cancer cells which prevents estrogen from binding to these receptors.
Frequency defined:
>10%
Skin changes
Weight loss
Irregular menstrual cycle
Nausea
Vomiting
1%-10%
Chest pain
Ovarian cyst
Abdominal cramps
Anorexia
Anxiety
Dizziness
<1%
Decreased serum cholesterol
Cerebrovascular accident
Black Box Warning:
None
Contraindication/Caution:
Contraindications
Hypersensitivity
Undiagnosed vaginal bleeding
Pulmonary embolism
Deep vein thrombosis
Pregnancy Warnings:
Pregnancy category: N/A
Lactation: Excretion of the drug into the human breast milk is unknown
Pregnancy categories:
Pharmacology
The interference of estrogen-receptors inhibits the cancer cells reception of estrogen signals which blocks the stimulation for growth and multiplication.
Pharmacodynamics
Tamoxifen re-evaluation proven successful for aromatase enzyme system inhibitors which targets to block estrogen synthesis from androgens previous generation.
Pharmacokinetics:
Limited information is available on ADME.
Administration:
It is taken orally as oral dosage form.
Patient information leaflet
Generic Name: Tamoxifen
Pronounced: ta-MOK-sih-fen
Why do we use tamoxifen?
Tamoxifen is commonly used to treat breast cancer that depends on estrogen to grow. It helps reduce the risk of cancer returning after initial treatment. It is used to lower the chance of developing breast cancer in women with a high risk.
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