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Brand Name :
Dyrenium
Synonyms :
triamterene
Class :
Diuretics, Potassium-Sparing
Brand Name :
Dyrenium
Synonyms :
triamterene
Class :
Diuretics, Potassium-Sparing
ADULT DOSING
Dosage Forms & Strengths
Capsule
50 mg
100 mg
Take a dose of 100 to 300 mg orally every day or divided dose every 12 hours
Take a dose of 50 to 100 mg orally every day
Dosing modifications
Renal Impairment
For CrCl <10 ml: Avoid use
Hepatic Impairment
Decrease dose in patients with cirrhosis
Dosage Forms & Strengths
Capsule
50 mg
100 mg
Take a dose of 1 to 2 mg/kg daily divided every 12 hours
Refer to adult dosing
may increase the hyperkalemic effect of potassium salts
may enhance the potassium levels in the blood when combined with sparsentan.
the serum levels of potassium may be increased
may enhance the hyperkalemic effect of ACE Inhibitors
may enhance the hyperkalemic effect of ACE Inhibitors
may enhance the hyperkalemic effect of ACE Inhibitors
may enhance the hyperkalemic effect of ACE Inhibitors
may enhance the hyperkalemic effect of ACE Inhibitors
may have an increased hyperkalemic effect when combined with angiotensin-converting enzyme inhibitors
may have an increased hyperkalemic effect when combined with angiotensin-converting enzyme inhibitors
may have an increased hyperkalemic effect when combined with angiotensin-converting enzyme inhibitors
may have an increased hyperkalemic effect when combined with angiotensin-converting enzyme inhibitors
may have an increased hyperkalemic effect when combined with angiotensin-converting enzyme inhibitors
the hypotensive effect of pramipexole is increased with triamterene
The interaction may enhance the hypotensive effects of opioid anti-tussive agents
The interaction may enhance the hypotensive effects of opioid anti-tussive agents
The interaction may enhance the hypotensive effects of opioid anti-tussive agents
Diacerein may increase the therapeutic effect of Diuretics
it may enhance the serum potassium levels
may increase the toxic effects of diuretics
may enhance the adverse/toxic effect of diuretics
may enhance the adverse/toxic effect of diuretics
may enhance the adverse/toxic effect of diuretics
may enhance the adverse/toxic effect of diuretics
may increase the hyperkalemic effect of diuretics
may increase the hyperkalemic effect of angiotensin receptor II blockers
may increase the toxic effect of angiotensin receptor II blockers
It may enhance the risk of adverse reactions when combined with Potassium
may have an increased hyperkalemic effect when combined with potassium-sparing diuretics
may have an increased hyperkalemic effect when combined with potassium-sparing diuretics
may have an increased hyperkalemic effect when combined with potassium-sparing diuretics
may enhance the effects of the other by pharmacodynamic synergism
Triamterene directly blocks the epithelial sodium channels (ENaCs) in the distal tubules of the kidneys. It inhibits the reabsorption of the Na ions and decreases the excretion of H and K and increases the excretion of the Na in the urine. It does not depend on the activity of aldosterone.
Triamterene is not antimicrobial agent. It regulates electrolyte balance. It changes acid&base balances.
Frequency defined
1-10%
Fatigue
Photosensitivity
Rash
CHF
Nausea
Vomiting
Hyperuricemia
Edema
Hypotension
Dizziness
Diarrhea
Nephrotoxicity
Frequency not defined
Thrombocytopenia
GI upset
Nephrolithiasis
None
Contraindication:
Triamterene is contraindicated in patients who have anuria, severe kidney impairment, hyperkalemia. Or taking the supplement of K.
Caution:
Caution is taken in patients who have mild to severe impairment in renal. Caution is taken in patients who have imbalances in the electrolytes.
Pregnancy consideration:
Pregnancy category: N/A
Lactation: Excretion into human milk is unknown
Pregnancy Categories:     
Category A: Studies which are well controlled and satisfy show that there is no risk to the fetus in the 1st or later trimester.
Category B: There is no evidence of risk to te fetus in the animal study. There is not enough studies on pregnant women.
Category C: There is some evidence of risk of adverse effects in animal reproduction study. No sufficient evidence in human study have taken care of the potential risk on pregnant women.
Category D: Adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.
Category N: There is no data available for the drug under this category.
Pharmacology
Triamterene mainly affects the distal convoluted tubules and collecting ducts of nephron in the kidney. It inhibits the reabsorption of sodium ions in the exchange of potassium ions in the distal tubules.
Pharmacodynamics
Triamterene decreases the loss of potassium in the urine.
Pharmacokinetics
Absorption
Triamterene absorbed by the GI tract. The onset of action takes place in 2 to 4 hours after the oral administration. The peak plasma level is achieved in 1 to 2 hours.
Distribution
Triamterene circulated in whole body. It binds to bound proteins.
Metabolism
Triamterene has minimum hepatic metabolism. Hydroxytriamterene sulfate mainly metabolize triamterene.
Elimination and excretion
Triamterene is eliminated or excreted by renal pathway. The half-life of triamterene is about 1.5 to 2 hours. Active metabolite of it has a longer half-life about 3 to 5 hours.
Administration of triamterene is available in form of capsules.
Patient information leaflet
Generic Name: triamterene
Why do we use triamterene?
Edema or accumulation of excess fluid in the tissues of the body is treated with triamterene. It is also used to treat the hypertension, to prevent hypokalemia or as a combination treatment.
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