Anthropometric Measurements as Predictors of Low Birth Weight Among Tanzanian Neonates: A Hospital-Based Study
November 7, 2025
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Brand Name :
Painaid PMF premenstrual formula,backaid max,midol teen
Synonyms :
acetaminophen/pamabrom
Class :
analgesic
Brand Name :
Painaid PMF premenstrual formula,backaid max,midol teen
Synonyms :
acetaminophen/pamabrom
Class :
analgesic
Dosage Forms & Strengths
Caplet
500mg/25mg
Tablet
325mg/25mg
Indicated for menstrual cramps:
1-2 caplets orally every 4-6 hours whenever necessary. Do not exceed eight caplets for 24 hours
Dosage Forms & Strengths
Caplet
500mg/25mg
Tablet
325mg/25mg
Indicated for menstrual cramps:
<12 years: Safety and efficacy not established
>12 years: 1-2 caplets orally every 4-6 hours whenever necessary. Do not exceed 8 caplets for 24 hours
Refer adult dosing
may increase the hepatotoxic effect of acetaminophen
may increase the serum concentration
may increase the hepatotoxic effect
may enhace the serum concentration of each other when it is combined
may enhace the serum concentration of each other when it is combined
may enhace the serum concentration of each other when it is combined
may enhace the serum concentration of each other when it is combined
may enhace the serum concentration of each other when it is combined
may enhance the metabolism
may increase the hepatotoxic effect of acetaminophen
may increase the toxic effect of acetaminophen
may increase the hepatotoxic effect of acetaminophen
may increase the hepatotoxic effect of acetaminophen
may enhance the serum concentration of acetaminophen
may increase the hepatotoxic effect of acetaminophen
may reduce the therapeutic effect of immune checkpoint inhibitors
may reduce the therapeutic effect of immune checkpoint inhibitors
may reduce the therapeutic effect of immune checkpoint inhibitors
may reduce the therapeutic effect
may reduce the therapeutic effect
may reduce the therapeutic effect
may increase the levels of serum concentration
may increase the levels of serum concentration
may increase the levels of serum concentration
may increase the levels of serum concentration
may increase the levels of serum concentration
may increase the levels of serum concentration
may increase the levels of serum concentration
may increase the levels of serum concentration
may increase the levels of serum concentration
may increase the levels of serum concentration
may increase the levels of serum concentration
may increase the levels of serum concentration
may increase the levels of serum concentration
may increase the levels of serum concentration
may increase the levels of serum concentration
may increase the levels of serum concentration
may increase the levels of serum concentration
may increase the levels of serum concentration
may increase the levels of serum concentration
may increase the levels of serum concentration
may increase the levels of serum concentration
may increase the levels of serum concentration
may increase the levels of serum concentration
may increase the levels of serum concentration
may increase the levels of serum concentration
may increase the levels of serum concentration
may increase the levels of serum concentration
may increase the levels of serum concentration
may increase the levels of serum concentration
may increase the levels of serum concentration
an increase in CNS depression may be seen
cinnarizine and dimenhydrinateÂ
this combination will make you feel sleepy or tired when Analgesics used in combination
Mechanism of action
acetaminophen (also known as paracetamol) is a pain reliever and a fever reducer. It works by blocking the production of prostaglandins, substances that cause pain and inflammation in the body. The mechanism of action of acetaminophen is not fully understood, but it is believed to inhibit the production of prostaglandins in the central nervous system.
pamabrom is a diuretic drug used to treat water retention (edema) and swelling. It works by increasing urine output, which helps reduce the body’s fluid. Pamabrom acts primarily on the kidney, increasing salt and water excretion
Spectrum
The spectrum of activity of acetaminophen is primarily for mild to moderate pain and reduction of fever. It is effective for headaches, toothaches, menstrual cramps, muscle aches, and joint pain. Still, it is ineffective for more severe pain, such as arthritis or cancer
The spectrum of pamabrom activity is limited to treating edema and swelling. It is not practical for other medical conditions, and it should not be used to treat high blood pressure or other heart and blood vessel problems
Frequency undefined:
Urticaria
Angioedema
Thrombocytopenia
Pancytopenia
Thrombocytopenic purpura
Hepatotoxicity
Maculopapular rash
Laryngeal edema
Anaphylactoid reaction
Leukopenia
Neutropenia
Agranulocytosis
Contraindications
Hepatic impairment
Hypersensitivity
Caution
Acetaminophen:
It is generally considered safe when taken as directed, but taking high doses or using it for prolonged periods can lead to liver damage. People who drink three or more alcoholic drinks daily should avoid using acetaminophen. It is also essential to avoid taking acetaminophen with other medications that contain acetaminophen, as this can lead to an accidental overdose.
pamabrom:
It can cause dehydration, electrolyte imbalances, or low blood pressure. It should be used with caution in people with kidney, liver, or heart disease. It may interact with other medications, so it is essential to inform your doctor of all medications you are taking before using pamabrom
Pregnancy consideration: C
Lactation: Excretion of the drug in human breast milk is known
Pregnancy category:
Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester.
Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.
Category D: adequate data available with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.
Category N: There is no data available for the drug under this category
Pharmacology
acetaminophen (also known as paracetamol) is a widely used non-steroidal anti-inflammatory drug (NSAID) that works as a peripheral analgesic and antipyretic. It works by blocking the production of prostaglandins, which are responsible for pain, fever, and inflammation. acetaminophen is metabolized mainly in the liver and has few adverse effects on the gastrointestinal system, which makes it a preferred pain reliever compared to other NSAIDs.
pyrilamine Maleate (pamabrom) is a mild central nervous system stimulant and a mild diuretic. It acts as a mild stimulant on the CNS, which can cause mild CNS stimulation, including increased alertness, improved mood, and decreased drowsiness. As a diuretic, Pamabrom increases urine output by decreasing sodium and water reabsorption in the renal tubules. This leads to increased excretion of excess fluid, which can help to reduce swelling, bloating, and edema caused by various conditions.
It’s important to note that while both drugs have a relatively low risk of adverse effects, they can interact with other medications and should be used only as directed by a healthcare professional. Additionally, long-term use of pamabrom should be avoided as it can lead to dehydration and electrolyte imbalances
Pharmacodynamics
acetaminophen is believed to work by blocking the production of prostaglandins in the central nervous system and the body’s peripheral tissues. Prostaglandins are chemical messengers that play a role in pain, fever, and inflammation. By blocking the production of prostaglandins, acetaminophen can reduce pain and fever and have a mild anti-inflammatory effect.
On the other hand, pamabrom works as a mild central nervous system stimulant and a diuretic. As a central nervous system stimulant, pamabrom increases alertness, improves mood, and decreases drowsiness by increasing the activity of certain neurotransmitters in the brain. As a diuretic, it promotes the loss of excess fluid from the body by increasing sodium and water excretion in the urine. This can help to reduce swelling and bloating caused by conditions such as edema and premenstrual syndrome.
Pharmacokinetics
Absorption
acetaminophen is rapidly absorbed from the gastrointestinal tract, reaching peak plasma concentrations in about 30-60 minutes after oral administration. pamabrom is rapidly absorbed from the gastrointestinal tract, reaching peak plasma concentrations about 1-2 hours after oral administration.
Distribution
Both drugs are distributed throughout the body and have a large volume of distribution, suggesting that it is widely distributed in tissues.
Metabolism
acetaminophen is primarily metabolized in the liver by the cytochrome P450 enzyme system. pamabrom is also primarily metabolized in the liver by the cytochrome P450 enzyme system.
Elimination/excretion
acetaminophen is excreted mainly in the urine as glucuronide and sulfate conjugates. pamabrom is excreted mainly in the urine as an unchanged drug and its metabolites.
Administration
acetaminophen and pamabrom are usually administered orally in tablets, capsules, or syrups. They can also be found with other medications, such as pain relievers, decongestants, or sleep aids
Patient information leaflet
Generic Name: acetaminophen/pamabrom
Pronounced: [ a-seet-a-MIN-oh-fen-& PAM-a-brom ]
Why do we use acetaminophen/pamabrom?
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