Anthropometric Measurements as Predictors of Low Birth Weight Among Tanzanian Neonates: A Hospital-Based Study
November 7, 2025
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Brand Name :
Mervan, Reufenac
Synonyms :
Alclofenac, alclofenaco, alclofenacum
Class :
NSAIDS
Brand Name :
Mervan, Reufenac
Synonyms :
Alclofenac, alclofenaco, alclofenacum
Class :
NSAIDS
Dosage Forms & Strengths
Data not available
Refer to adult dosing
may decrease the serum concentration when combined with each other
may increase the risk of hyperglycemia when combined
When suprofen is taken in conjunction with alclofenac, there is a potential for an enhance in the seriousness of adverse events
meticrane has the potential to enhance the rate of excretion of alclofenac; this can potentially lead to decreased levels of serum, possibly diminishing its effectiveness
It may enhance the risk of bleeding when combined with nimesulide
When loracarbef is used together with alclofenac, the risk or seriousness of nephrotoxicity is enhanced
When alclofenac is used together with piroxicam, this leads to enhanced risk or seriousness of adverse outcomes
When antrafenine is used together with alclofenac, this leads to enhanced risk or seriousness of adverse outcomes
When melitracen is used together with alclofenac, this leads to increased risk or seriousness of gastrointestinal bleeding
When andrographolide is used together with alclofenac, this leads to enhanced risk or seriousness of bleeding
When alclofenac is used together with proglumetacin, this leads to enhanced risk or seriousness of adverse events
When alclofenac is used together with bufexamac, this leads to enhanced risk or seriousness of adverse events
When alclofenac is used together with vilanterol, this leads to enhanced risk or seriousness of hypertension
When alclofenac is used together with benoxaprofen, this leads to enhanced risk or seriousness of adverse events
alclofenac leads to a reduction in the rate of excretion of eucalyptus oil which leads to increased level of serum
When alclofenac is used together with fenbufen, this leads to enhanced risk or seriousness of adverse events
alclofenac leads to a reduction in the rate of excretion of chromous sulfate, which leads to an increased level of serum
alclofenac leads to a reduction in the rate of excretion of pentaerythritol tetranitrate, which leads to an increased level of serum
alclofenac leads to a reduction in the rate of excretion of estrone sulfate, which leads to an increased level of serum
alclofenac leads to a reduction in the rate of excretion of nitric oxide, which leads to an increased level of serum
alclofenac: it may decrease the excretion rate of iothalamic acid
When alclofenac is used together with nifenazone, this leads to enhanced risk or seriousness of adverse events
alclofenac: it may decrease the excretion rate of isepamicin
alclofenac: it may increase the risk of hypertension with moxisylyte
the rate of excretion may be reduced
the risk of hemorrhage and bleeding may be increased
the antihypertensive activity of acebutolol may be reduced
the risk of adverse effects may be increased
the risk of adverse effects may be increased
the risk of hemorrhage and bleeding may be increased
the rate of excretion of alclofenac may be increased
the protein binding efficacy of acetohexamide may be reduced
the risk of adverse effects may be increased
the rate of excretion of aclidinium may be reduced
the risk of nephrotoxicity may be increased
the rate of excretion of albutrepenonacog alfa may be reduced
the risk of adverse effects may be increased
the risk of hypertension and renal failure may be increased
the rate of excretion of alprazolam may be reduced
the antihypertensive activity of amlodipine may be reduced
the risk of hypertension may be increased
the rate of excretion of ancestim may be reduced
the risk of bleeding may be increased
the risk of adverse effects may be increased
choline magnesium trisalicylate
the hazard or intensity of adverse effects can be heightened when Choline magnesium trisalicylate is combined with alclofenac
alclofenac: it may decrease the therapeutic efficacy of phentolamine
When alclofenac is used together with diazoxide, this leads to reduction in therapeutic effectiveness of diazoxide
may enhance the risk or severity of hypertension when combined
the risk of gastrointestinal bleeding may be reduced
the risk of adverse effects may be increased
the risk of adverse effects may be increased
the risk of hypertension may be increased
the therapeutic effect of Remikiren may be reduced
the risk of hypertension, renal failure, and hypokalemia may be increased
alclofenac might lead to a reduction in the rate of excretion of telavancin, potentially leading to elevated levels of serum
Actions and spectrum:
Actions:
Alclofenac halts an enzyme called prostaglandin H2 synthase. This stops its function. The enzyme is also known as cyclooxygenase. Alclofenac reversibly blocks the enzyme’s activity. This prevents the creation of prostaglandins and prostacyclins. These molecules drive inflammation and pain. Alclofenac’s core mechanism involves hindering prostaglandin synthesis. However, it may also work by displacing anti-inflammatory substances from plasma proteins. Freeing these substances likely enhances Alclofenac’s effectiveness.
Spectrum:
Alclofenac has uses for managing pain and swelling from joint troubles. It helps with degenerative diseases affecting the joints. It works for rheumatoid arthritis, a condition causing inflamed joints. Also, alclofenac reduces inflammation and pain.
Frequency not defined
Rashes on skin
Reduced gut motility
Black Box Warning
No special black box warnings are available for this drug
Contraindication/Caution:
Contraindication:
Hypersensitivity
Caution:
Stroke
Myocardial infarction
Precautions:
Renal impairment
Pregnancy consideration:
USFDA pregnancy category: Not assigned
Lactation:
Data about the excretion of alclofenac into breast milk is not known
Pregnancy category:
Category A: Studies that were well-controlled and met expectations revealed no risk to the fetus in either the first or second trimester.
<b>Category B: There was a lack of studies on pregnant women and no evidence of risk to the fetus in animal experiments.
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.
Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.
Category X: Drugs listed in this category outweigh the risks over benefits. Hence, these categories of drugs need to be avoided by pregnant women.
Category N: There is no data available for the drug under this category
Pharmacology:
Alclofenac is a medicine that helps with pain and swelling. It stops a body chemical that causes hurt and redness. Alclofenac can upset stomachs or damage hearts, though. Doctors must be careful when they prescribe it because of risks. Still, this drug helps many people feel better when inflammation and pain strike. It blocks enzymes that make the body react badly. But alclofenac also brings dangers, like most medicines do.
Pharmacodynamics:
Alclofenac is made from phenylacetic acid. Like diclofenac, it is an anti-inflammatory medicine. Both drugs block an enzyme called cyclooxygenase. This reduces pain and swelling. For example, they may help arthritis. However, they have slight differences in strength and side effects. Doctors must choose carefully between them.
Pharmacokinetics:
Absorption
After alclofenac enters your stomach, it may take one hour for it to reach your bloodstream. But sometimes, it can take up to four hours for this to happen! Alclofenac absorption varies greatly from the digestive system.
Distribution
The volume of distribution (Vd) for alclofenac indicates its distribution throughout the body relative to blood concentration. With a Vd of 0.1 L/kg and high protein binding (90-99%), alclofenac primarily stays in the bloodstream, influencing its pharmacological activity and metabolism.
Metabolism
Alclofenac transforms itself in the liver. It creates alclofenac glucuronide, its main by-product. This happens during its metabolism.
Elimination and excretion
Mainly, Alcofenac gets removed from the body through urine. It exits as a substance called glucuronide. Alcofenac’s half-life, or how long it stays in the system, ranges between 1.5 to 5.5 hours
Administration:
Alclofenac should be taken with meals or immediately after taking meals.
Patient information leaflet
Generic Name: alclofenac
Why do we use alclofenac?
Alclofenac is often used by doctors treating rheumatism. It helps people with conditions like ankylosing spondylitis and rheumatoid arthritis. The medicine reduces pain from arthritis that causes joints to hurt.
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