A Milestone Moment: FDA Approves Addyi® for Hypoactive Sexual Desire Disorder in Postmenopausal Women
December 17, 2025
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Brand Name :
Not available
Synonyms :
Aspirin rectal
Class :
Platelet aggregation inhibitors, salicylates
Brand Name :
Not available
Synonyms :
Aspirin rectal
Class :
Platelet aggregation inhibitors, salicylates
Dosage Forms & Strengths
Suppository
60mg
120mg
200mg
300mg
600mg
Indicated as Analgesic and antipyretic
Take 300mg to 600mg rectally every 4 hours to 6 hours when required
Dosage Forms & Strengths
Suppository
120mg
200mg
300mg
600mg
Indicated as Analgesic and Antipyretic
For Less than 12 years of age:
10-15mg/kg per dose, rectally, every 4 hours to 6 hours, not exceeding a dose of 4g/day
More than 12 years of age:
300-600mg rectally, every 4 hours- 6 hours, when required
Refer to adult dosing
levels of aspirin may be increased when combined with dichlorphenamide
excessive bleeding can be seen during abortion if mifepristone is taken with aspirin due to anti-platelet activity
The efficacy of abciximab may be increased by aspirin rectal due to pharmacodynamic synergism
The efficacy of anagrelide may be increased by aspirin rectal due to pharmacodynamic synergism
A decrease in renal function may be seen when aspirin rectal and benazepril are coadministered due to pharmacodynamic antagonism
A decrease in renal function may be seen when aspirin rectal and captopril are coadministered due to pharmacodynamic antagonism
efficacy of clopidogrel may be increased by aspirin rectal due to pharmacodynamic synergism
The efficacy of dipyridamole may be increased by aspirin rectal due to pharmacodynamic synergism
A decrease in renal function may be seen when aspirin rectal and enalapril are coadministered due to pharmacodynamic antagonism
The efficacy of eptifibatide may be increased by aspirin rectal due to pharmacodynamic synergism
A decrease in renal function may be seen when aspirin rectal and fosinopril are coadministered due to pharmacodynamic antagonism
the efficacy of aspirin rectal may be decreased by ibuprofen
when administered together, the toxicity of either of the drugs is increased by pharmacodynamic synergism
A decrease in renal function may be seen when aspirin rectal and lisinopril are coadministered due to pharmacodynamic antagonism
the level of methotrexate may be increased by aspirin rectal by reducing renal clearance
A decrease in renal function may be seen when aspirin rectal and perindopril are coadministered due to pharmacodynamic antagonism
uricosuric acid activity of probenecid is decreased by aspirin
The efficacy of ticlopidine may be increased by aspirin rectal due to pharmacodynamic synergism
may increase the anticoagulation when combined with ginkgo biloba
It may enhance the risk of adverse effects when combined with Platelets inhibitors
It may enhance the risk of adverse effects when combined with Platelets inhibitors
It may enhance the risk of adverse effects when combined with Platelets inhibitors
It may enhance the risk of adverse effects when combined with Platelets inhibitors
It may enhance the risk of adverse effects when combined with Platelets inhibitors
It may enhance the risk of adverse effects when combined with platelet Inhibitors
It may enhance the risk of adverse effects when combined with platelet Inhibitors
It may enhance the risk of adverse effects when combined with platelet Inhibitors
It may enhance the risk of adverse effects when combined with platelet Inhibitors
dexchlorpheniramine, dextromethorphan, and phenylephrine
It may enhance the risk of adverse effects when combined with platelet Inhibitors
It may enhance the risk of adverse effects when combined with platelet inhibitors
It may enhance the risk of adverse effects when combined with platelet inhibitors
the anticoagulating effect can be increased when aspirin rectal is taken with agrimony
the activity of alfuzosin may be reduced with aspirin rectal by pharmacodynamic antagonism
the anticoagulating effect can be increased when aspirin rectal is taken with alteplase
the toxicity of either of the drugs is increased when administered together due to pharmacodynamic synergism
the serum levels of potassium are reduced by chlorothiazide, whereas levels of potassium are increased by aspirin rectal
nafcillin and asprin rectal, both either increase the levels of others by plasma protein binding or by decreasing renal clearance.
lansoprazole amoxicillin and clarithromycin
when amoxicillin combines with aspirin rectal it decreases the effects of action of drug by plasma binding protein and results in lowering of renal clearance
amoxicillin and clavulanate potassium
when amoxicillin combines with aspirin rectal it decreases the effects of action of drug by plasma binding protein and results in lowering of renal clearance
omeprazole amoxicillin and clarithromycin
when both drugs are combined, there may be a decreased effect of the drug's action by decreasing renal clearance
when both drugs are combined, there may be a decreased effect of the drug's action by decreasing renal clearance
It may enhance the risk of adverse effects when combined with general anesthesia
It may enhance the risk of adverse effects when combined with general anesthesia
It may enhance the risk of adverse effects when combined with general anesthesia
It may enhance the risk of adverse effects when combined with general anesthesia
piperacillin increases the effectiveness of aspirin rectal by protein binding competition.
both, when used simultaneously, increases the effect on other through a synergistic activity
Actions and spectrum:
Aspirin acts by preventing the production of prostaglandins by cyclooxygenases 1 and 2 through acetylation. It also prevents platelet aggregation by acetylating platelet cyclooxygenase, which prevents the formation of the prostaglandin derivative thromboxane A2.
Frequency not defined
Urticaria
Angioedema
Hives
Thrombocytopenia
Tachycardia
Hypotension
Bronchospasm
Reye syndrome
Hearing loss
Headache
Black Box Warning
Do not use it in children or teenagers suffering from Chicken pox or flu as it may cause fatal or severe Reye’s syndrome.
Contraindication/Caution:
Contraindication:
Hypersensitivity
Renal impairment
Hepatic impairment
Caution:
Bleeding of peptic ulcer
Gastrointestinal bleed
Pregnancy consideration:
USFDA pregnancy category: D
Lactation:
The drug is known to be excreted in human milk
Pregnancy category:
Category A: Studies that were well-controlled and met expectations revealed no risk to the fetus `in either the first or second trimester.
Category B: There was a lack of studies on pregnant women and no evidence of risk to the fetus in animal experiments.
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.
Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.
Category X: Drugs listed in this category outweigh the risks over benefits. Hence, these categories of drugs need to be avoided by pregnant women.
Category N: There is no data available for the drug under this category
Pharmacology:
Aspirin rectal is an analgesic and antipyretic belonging to the group salicylates
Pharmacodynamics:
Pharmacokinetics:
Absorption
Aspirin rectal is absorbed 60%
Distribution
The volume of distribution is 150mg/ml
50-80% of the drug is protein-bound
Metabolism
Undergoes metabolism in the liver by hydrolysis
Elimination and excretion
5.6-35.6% of the drug is eliminated through urine
Half-life:
4.7- 9 hours
Administration:
The patient should lie on their left side, knees bent.
Before inserting, remove the protective wrap.
With the suppository tip pointing toward the navel, gently insert it into the rectum with little side-to-side movement.
Patient information leaflet
Generic Name: aspirin rectal
Why do we use aspirin rectal?
Aspirin rectal is used in the treatment of menstrual cramps, pain, arthritis, etc. It is also used in relieving fever and headache.
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