Long COVID Patterns in the RECOVER-Adult Study
November 21, 2025
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Brand Name :
Gluconate, Ca
Synonyms :
Calcarea gluconica, Calcio gluconate, calcium di-gluconate, Calcii gluconas
Class :
Antidotes and other calcium salts
Brand Name :
Gluconate, Ca
Synonyms :
Calcarea gluconica, Calcio gluconate, calcium di-gluconate, Calcii gluconas
Class :
Antidotes and other calcium salts
Adult
Dosage Forms & Strengths
Injection
10%
Capsule
500 mg
Tablet
650 mg
500 mg
50 mg
For management of the mild Ca condition
1-3 gm each day orally in divided doses
1-2 gm intravenously for 2 hours
For the management of the severe Ca condition
Without tetany or seizures, 0.5 mg/kg/hr intravenously
Maintain the dose at 2 mg/kg/hr
Do not exceed more than 3-4 g intravenously for 4 hours
Hypocalcemic tetany- 100-300 mg elemental calcium, which is equivalent to 3 g calcium gluconate intravenously for 5-10 minutes, followed by continuous intravenous infusion at 0.5 mg/kg/hr
May increase to 2 mg/kg/hr
Monitor the levels of serum calcium every 4-6 hours to maintain the levels
(Off-label)
1.5-3 gm intravenously infused for 2-5 minutes
(Off-label)
1.5-3 gm intravenously infused for 2-5 minutes
Dosage Forms & Strengths
Injection
10%
Tablet
650mg
500mg
50mg
Used as calcium supplementation
For 0-6 months old, 210 mg orally divided every 2-3 times a day
For 7-12 months old, 270 mg orally divided every 2-3 times a day
For 1-3 years old, 500 mg orally divided every 2-3 times a day
For 4-8 years old, 800 mg orally divided every 2-3 times a day
For 9-18 years, 1300 mg orally divided every 2-3 times a day
For mild condition
In neonates- 500-1500 mg/kg orally divided every 4-6 hours each day
In infants and children- 500-725 mg/kg orally divided every 6-8 hours each day
For severe condition
In neonates, 200-800 mg/kg intravenously each day through continuous infusion or divided every 6 hours as intermittent infusions
For infants or children, 200-500 mg/kg intravenously each day through
continuous infusion or divided every 6 hours as intermittent infusions
Hypocalcemic tetany
100-200 mg/kg intravenously every 10 minutes
It may be repeated 6 hours later or start over continuous infusion
Do not exceed 500 mg/kg each day
Indicated for calcium supplementation
For 0-6 months old, 210 mg orally divided every 2-3 times a day
For 7-12 months old, 270 mg orally divided every 2-3 times a day
For 1-3 years old, 500 mg orally divided every 2-3 times a day
For 4-8 years old, 800 mg orally divided every 2-3 times a day
For 9-18 years, 1300 mg orally divided every 2-3 times a day
Refer to the adult dosingÂ
may decrease the serum concentration of Quinolones
may decrease the serum concentration of Quinolones
may diminish the absorption when combined with quinolones
may diminish the absorption when combined with quinolones
calcium salts: they may diminish the absorption of phosphate binders
calcium salts: they may diminish the absorption of phosphate binders
calcium salts: they may diminish the absorption of phosphate binders
calcium salts: they may diminish the absorption of phosphate binders
calcium salts: they may diminish the absorption of phosphate binders
may diminish the therapeutic efficacy of each other when combined
may diminish the rate of excretion when combined
may diminish the rate of excretion when combined
may diminish the rate of excretion when combined
may diminish the rate of excretion when combined
calcium gluconate: it may increase the risk or severity of QTc prolongation
calcium gluconate: it may increase the risk or severity of QTc prolongation
calcium gluconate: it may increase the risk or severity of QTc prolongation
calcium gluconate: it may increase the risk or severity of QTc prolongation
calcium gluconate: it may increase the risk or severity of QTc prolongation
when both drugs are combined, there may be an increased risk or severity of adverse effects  
may increase the CNS depressant effect of CNS Depressants
ciprofloxacin inhaled (Pending FDA approval)Â
may diminish the absorption of Quinolones
may increase the toxic effects of vitamin D analogs
calcium gluconate inhibits the GI absorption of demeclocycline (provide 2 hours difference between both drugs)
calcium gluconate inhibits the GI absorption of doxycycline (provide 2 hours difference between both drugs)
calcium salts increase the efficacy of calcium acetate
calcium salts reduce the efficacy of calcium channel blockers
calcium salts reduce the efficacy of calcium channel blockers
calcium salts reduce the efficacy of calcium channel blockers
calcium salts reduce the efficacy of calcium channel blockers
calcium salts reduce the efficacy of calcium channel blockers
calcium salts increase the toxicity of vitamin D analogs
bismuth subcitrate, metronidazole and tetracycline
may decrease the levels of serum concentration
may decrease the levels of serum concentration
may decrease the levels of serum concentration
may decrease the levels of serum concentration
may decrease the levels of serum concentration
may decrease the levels of serum concentration
may decrease the levels of serum concentration
may decrease the levels of serum concentration
It may enhance the levels when combined with sodium polystyrene sulfonate by diminishing renal clearance
It may diminish the effect when combined with manganese by inhibiting the gastrointestinal absorption
calcium salts enhance the arrhythmogenic effects of cardiac glycosides
calcium salts enhance the arrhythmogenic effects of cardiac glycosides
calcium salts enhance the arrhythmogenic effects of cardiac glycosides
may diminish the calcium salts excretion
may diminish the calcium salts excretion
calcium gluconate: it may decrease the therapeutic efficacy of oxprenolol
When calcium gluconate is used together with clomocycline, this leads to reduction in concentration serum of clomocycline
may diminish the therapeutic efficacy of each other when combined
may diminish the therapeutic efficacy of each other when combined
the risk or intensity of adverse effects can be heightened when calcipotriol is combined with calcium gluconate
the risk or magnitude of adverse effects can be elevated when tacalcitol is associated with calcium gluconate
it May enhance the antiplatelet effect of Agents with antiplatelet Properties
it May enhance the antiplatelet effect of Agents with antiplatelet Properties
it May enhance the antiplatelet effect of Agents with antiplatelet Properties
it May enhance the antiplatelet effect of Agents with antiplatelet Properties
it May enhance the antiplatelet effect of Agents with antiplatelet Properties
may decrease the serum concentration of minerals
may decrease the serum concentration of minerals
may increase the hypotensive effect of anti-hypertensives
hydrochlorothiazide/aliskirenÂ
may decrease the excretion of thiazide, and thiazide like diuretics
may decrease the therapeutic effect of calcium channel blockers
may decrease the serum concentration
may decrease the serum concentration
may decrease the serum concentration
may decrease the serum concentration
may decrease the serum concentration
calcium salts have the potential to intensify the arrhythmogenic effect of cardiac glycosides
calcium salts have the potential to intensify the arrhythmogenic effect of cardiac glycosides
calcium salts have the potential to intensify the arrhythmogenic effect of cardiac glycosides
The therapeutic efficacy of dobutamine may be diminished when used concurrently with calcium salts
may diminish the excretion when combined with calcium salts
may diminish the excretion when combined with calcium salts
the therapeutic activity of agmatine may be reduced with calcium gluconate
ispaghula husk may lower or decrease the rate of GI absorption of minerals (ca, zn, or fe)
Calcium is necessary for the bone health, nerve, muscle, and physiological process. Calcium gluconate is used to treat the hypocalcemia. It is caused because of the hypoparathyroidism, renal failure, or vitamin D deficiency. It can be used as an adjunct treatment cardiac resuscitation, specifically in the cases of hypocalcemia or hyperkalemia. It may lead to cardiac arrest. It is also used to treat osteoporosis. It is caused by weakened bones which are more prone to fractures. Calcium gluconate is used in neonatal care to treat hypocalcemia. It occurred because of different factors like prematurity, low birth weight, and maternal diabetes.
Frequency not defined
Bradycardia
Hypotension
Diarrhea
Flatulence
Headache
Constipation
Nausea
Vomiting
Extravasation necrosis
Hypomagnesemia
Hypophosphatemia
None
Hypercalcemia
Hypersensitivity
Cardiac arrest
Kidney impairment
Cardiac glycosides and thiazide diuretics
Pregnancy consideration:
Category C
Breastfeeding warnings:
The drug is excreted in breast milk. Utilize with caution.
Pregnancy category:
Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester.
Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.
Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.
Category N: There is no data available for the drug under this category.
Pharmacology:
Calcium gluconate is an important component of bone minerals. It also acts as a co-factor in different enzymatic reaction in the body. It is necessary for the muscle contraction, neurotransmission, and signal transduction pathways.
Pharmacodynamics:
Calcium gluconate supplementation is used in neonatal to treat hypocalcemia. It occurred because of prematurity, low birth weight, or maternal diabetes.
The pharmacodynamics of calcium gluconate may differ from the other calcium salts like calcium chloride or calcium carbonate. Pharmacokinetics:
The oral absorption needs vitamin D. Absorption is elevated with the acidic condition. Administer after 1 to 2 hours after the meals.
It is distributed in the protein-bound form mainly to the albumin about 45 %.
Metabolism
The drug is metabolized in liver.
The drug is excreted about 80% in the feces and 20% as an unabsorbed calcium salt in the urine.
Calcium gluconate is administered by slow IV infusion for many minutes. The suggested infusion rate is between 0.5 gm to 2 gm/minute. The concentration of calcium gluconate in infusion solution may vary from 5 to 10%.
Calcium gluconate is administered by IM injection, although this route of administration is rare. The suggested dosage for IM injection is between 0.5 to 1 gm.
Calcium gluconate is taken orally as a dietary supplement. The adult dose is 1 to 2 tablets (each contains 500 mg of calcium) for 3 times a day with meals. The dosage for children can vary on the basis of their age and weight.
Generic Name: calcium gluconate
Pronounced: KAL-see-um -GLOO-koe-nate
Why do we use calcium gluconate?
Calcium gluconate is used mainly to treat hypocalcemia, hyperkalemia, and cardiac resuscitation as an adjunct form and dietary supplement.
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