Anthropometric Measurements as Predictors of Low Birth Weight Among Tanzanian Neonates: A Hospital-Based Study
November 7, 2025
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Brand Name :
No Data Available.
Synonyms :
Cefaclor
Class :
Antibiotics & Cephalosporins (second generation)
Brand Name :
No Data Available.
Synonyms :
Cefaclor
Class :
Antibiotics & Cephalosporins (second generation)
Dosage forms and strengths
Capsule, Oral
250 mg
500 mg
Suspension Reconstituted, Oral:
125 mg/5ml (150ml)
250 mg/5ml (150ml)
375 mg/5ml (100ml)
Extended-release Tablet, Oral:
500 mg
500
mg
Tablet
Orally
every 12 hrs
7
days
500
mg
Tablet
Orally
every 8 hrs
5
days
Extend the therapy duration as per vital signs
250
mg
Tablet
Orally
every 8 hrs
10
days
It is used as an alternative for patients allergic to penicillin
250
mg
Tablet
Orally
every 8 hrs
5 - 7
days
Cefaclor can be used only if first-line beta-lactams cannot be used
Dosage forms & Strengths
Capsule, Oral
250 mg
500 mg
Suspension Reconstituted, Oral:
125 mg/5ml (150ml)
250 mg/5ml (150ml)
375 mg/5ml (100ml)
Extended-release Tablet, Oral:
500 mg
20 - 40
mg/kg
Tablet
Orally
every 8 hrs
do not exceed the dose above 1000 mg/day
the interaction decreases the therapeutic effects of the vaccine
the interaction decreases the therapeutic effects of the vaccine
the interaction decreases the therapeutic effects of the vaccine
bazedoxifene conjugated estrogens
cefaclor may reduce the therapeutic effects of oral forms of conjugated estrogen by altering gut microflora
cefaclor will reduce the therapeutic effects of oral forms of hormones by altering gut microflora
cefaclor will reduce the therapeutic effects of oral forms of hormones by altering gut microflora
furosemide may enhance the therapeutic effects of cefaclor
the interaction may increase the therapeutic effects of cefaclor
the interaction may increase the therapeutic effects of cefaclor
cefaclor reduces the therapeutic effects of sodium picosulfate by altering metabolism
cephalosporins may decrease serum concentration and enhance nephrotoxicity of aminoglycosides
enhance the serum drug concentration by reducing renal clearance
enhance the serum drug concentration by reducing renal clearance
may raise the risk of nephrotoxicity
cefaclor increases the anticoagulant activity of warfarin by an unknown mechanism
it may diminish the excretion rate when combined with estradiol valerate resulting in a greater serum level
When cefaclor is used together with ouabain, this leads to reduction in cefaclor excretion
When cefmenoxime is used together with cefaclor, this leads to enhanced risk or seriousness of nephrotoxicity
cefaclor leads to a reduction in the rate of excretion of chromous sulfate, which leads to an increased level of serum
cefaclor leads to a reduction in the rate of excretion of pentaerythritol tetranitrate, which leads to an increased level of serum
the risk or severity of nephrotoxicity and hypocalcemia can increase when cefaclor is combined with alendronic acid
cefaclor leads to a reduction in the rate of excretion of potassium acetate, which leads to an increased level of serum
cefaclor leads to a reduction in the rate of excretion of potassium perchlorate, which leads to an increased level of serum
cefaclor leads to a reduction in the rate of excretion of nitric oxide, which leads to an increased level of serum
cefaclor: it may increase the risk or severity of CNS depression
cefaclor: it may increase the risk or severity of CNS depression
cefaclor: it may increase the risk or severity of CNS depression
cefaclor: it may increase the risk or severity of CNS depression
cefaclor: it may increase the risk or severity of CNS depression
When cefaclor is used together with difenpiramide, this leads to enhanced risk or seriousness of nephrotoxicity
cefaclor may decrease the excretion rate of almasilate, leading to higher serum levels
cefaclor: it may decrease the excretion of CYP3A inhibitors
cefaclor: it may decrease the excretion of CYP3A inhibitors
cefaclor: it may decrease the excretion of CYP3A inhibitors
cefaclor: it may decrease the excretion of CYP3A inhibitors
cefaclor: it may decrease the excretion of CYP3A inhibitors
it increases the nephrotoxicity of cephalosporins
the severity of nephrotoxicity can be enhanced when cefaclor is administered with mufebutazone
may have a decrease in excretion when combined with cefaclor
cefaclor might lead to a reduction in the rate of excretion of telavancin, potentially leading to elevated levels of serum
cefaclor increases the serum concentration of other drugs by reducing renal clearance
cefaclor increases the serum concentration of other drugs by reducing renal clearance
cefaclor increases the serum concentration of other drugs by reducing renal clearance
the interaction reduces the effects of cefaclor
cefaclor increases the therapeutic effects of cyclopenthiazide
cefaclor increases the serum concentration of other drugs by reducing renal clearance
cefaclor will increase the effects of sulfasalazine
Action:
Cefaclor kills various bacteria by stopping their cell wall growth. It works against both Gram-positive and Gram-negative bacteria.
Spectrum:
Cefaclor fights against a broad spectrum of bacteria, including those causing urinary tract infections, soft tissue infections, and otitis media. Yet, it might not work against all strains, especially those resistant due to extended-spectrum beta-lactamases or other mechanisms.
Frequency defined
>10% For IV
Fever
Fatigue
Headache
Vomiting
Nausea
Rash
For oral:
Headache
Lymphopenia
Hypersensitivity
Upper respiratory tract infection
1-10%
Diarrhea
Insomnia
Bronchitis
Depression
Alopecia
Arthritis
Back pain
<1%
Pneumonia
Pancytopenia
Seizures
Fungal infection
Hemolytic anemia
Cellulitis
Black Box Warning
None
Contraindication/Caution:
Allergic reactions
Kidney disease
Gastrointestinal disease
Pregnancy and Breastfeeding:
Pregnancy consideration: Cefaclor is assigned under pregnancy category C. It should be used with caution for pregnant women.
Lactation: No data available for excretion in breast milk, it should be avoided due to potential side effects.
Pregnancy category:
Category A: Satisfactory and well-controlled studies show no evidence of risk to the fetus in the first trimester or the later trimester.
Category B: There is no evidence of risk to the fetus found in animal reproduction studies and there are not enough studies on pregnant women.
Category C: Adverse effects on the fetus found with evidence in animal reproduction studies and no adequate evidence for an effect in humans, care must be taken for potential risks in pregnant women.
Category D: There is adequate data available with sufficient evidence of human fetal risk from various platforms, but despite potential risks may be used only in emergency cases for potential benefits.
Category X: Drugs listed in this category outweigh risks over benefits. These category drugs should be prohibited for pregnant women.
Category N: There is no data available for the drug under this category.
Pharmacology: Cefaclor is a second-generation cephalosporin antibiotic.
Pharmacodynamics:
Cefaclor kills bacteria by stopping cell wall synthesis, binding to penicillin-binding proteins and disrupting peptidoglycan formation, weakening the cell wall, and causing cell death.
Pharmacokinetics:
Absorption
Cefaclor is quickly absorbed after taking it orally and reaches peak levels in the bloodstream within 30 to 60 minutes.
Distribution
Cefaclor distributes throughout the body, reaching effective levels in tissues and fluids like the respiratory tract, middle ear, urinary tract, and skin.
Metabolism
Cefaclor is minimally metabolized in the body, with only 10% to 15% converted to inactive forms.
Excretion and Elimination
Cefaclor is mostly removed unchanged in urine through filtration and secretion, with a half-life of about 0.6 to 0.9 hours in those with healthy kidneys.
Administration:
Cefaclor is typically administered orally in the form of capsules or oral suspension.
Patient information leaflet
Generic Name: Cefaclor
Pronounced: SEFF-uh-klor
Why do we use cefaclor?
Cefaclor is indicated for the treatment of several bacterial infections.
It is used in treatment of including urinary tract infections, pharyngitis, tonsillitis, and bronchitis.
It is used to treat Lower Respiratory Tract Infections including pneumonia.
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