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Brand Name :
N/A
Synonyms :
ceforanide
Class :
Second generation cephalosporin
Brand Name :
N/A
Synonyms :
ceforanide
Class :
Second generation cephalosporin
Dosage Forms & Strengths
Tablet
250 mg
500 mg
Powder for injection
500 mg
1 gm
2 gm
Take a dose of 250 mg to 500 mg orally two times a day
Administer dose of 1 gm to 2 gm intravenously two times a day for 1 to 2 weeks
Not determined
Refer to adult dosing
ceforanide: it may increase the risk of methemoglobinemia agents
ceforanide: it may increase the risk of methemoglobinemia agents
ceforanide: it may increase the risk of methemoglobinemia agents
ceforanide: it may increase the risk of methemoglobinemia agents
ceforanide: it may increase the risk of methemoglobinemia agents
may enhance the nephrotoxic effect of aminoglycosides
may enhance the nephrotoxic effect of aminoglycosides
may enhance the nephrotoxic effect of aminoglycosides
may enhance the nephrotoxic effect of aminoglycosides
may enhance the nephrotoxic effect of aminoglycosides
it may diminish the excretion rate when combined with estradiol valerate resulting in a greater serum level
It may enhance the risk of nephrotoxicity when combined with phenylbutazone
When ceforanide is used together with piroxicam, this leads to increased risk or seriousness of nephrotoxicity
When cefmenoxime is used together with ceforanide, this leads to enhanced risk or seriousness of nephrotoxicity
When ceforanide is used together with proglumetacin, this leads to enhanced risk or seriousness of nephrotoxicity
When ceforanide is used together with benoxaprofen, this leads to enhanced risk or seriousness of nephrotoxicity
ceforanide leads to a reduction in the rate of excretion of eucalyptus oil which leads to increased level of serum
ceforanide leads to a reduction in the rate of excretion of pentaerythritol tetranitrate, which leads to an increased level of serum
ceforanide leads to a reduction in the rate of excretion of potassium perchlorate, which leads to an increased level of serum
ceforanide leads to a reduction in the rate of excretion of nitric oxide, which leads to an increased level of serum
When ceforanide is used together with difenpiramide, this leads to enhanced risk or seriousness of nephrotoxicity
ceforanide may decrease the excretion rate of almasilate, leading to higher serum levels
ceforanide: it may decrease the excretion rate of amantadine
ceforanide: it may decrease the excretion rate of amikacin
ceforanide: it may decrease the excretion rate of amitriptyline
ceforanide: it may decrease the excretion rate of ammonium chloride
ceforanide: it may decrease the excretion rate of amoxicillin
ceforanide: it may decrease the excretion rate of bepotastine
ceforanide: it may decrease the excretion rate of bicisate
ceforanide: it may decrease the excretion rate of bismuth subgallate
ceforanide: it may decrease the excretion rate of bisoprolol
ceforanide: it may decrease the excretion rate of bivalirudin
ceforanide: it may decrease the excretion rate of bleomycin
ceforanide might lead to a reduction in the rate of excretion of telavancin, potentially leading to elevated levels of serum
alteplase: it may decrease the therapeutic efficacy of ceforanide
ambroxol: it may increase the risk of methemoglobinemia with ceforanide
aminophenazone: it may increase the risk of nephrotoxicity with ceforanide
Actions and Spectrum
ceforanide exerts its antibacterial action by interfering with the synthesis of the bacterial cell wall. It binds to and inhibits the activity of penicillin-binding proteins (PBPs) in the bacterial cell wall. This interference with cell wall synthesis weakens the bacterial cell wall, leading to cell lysis and ultimately the death of the bacteria.
Frequency not defined
Diarrhea
Vomiting
Stomach pain
Headache
Dizziness
Black Box Warning
None
Contraindication/Caution:
Contraindication:
Caution:
Pregnancy consideration:
Pregnancy category: N/A
Lactation: Excretion into human milk is unknown
Pregnancy Categories:
Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester.
Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.
Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.
Category N: There is no data available for the drug under this category.
Pharmacology
ceforanide interference disrupts the cell wall’s structure and integrity. As a result, the bacterial cell becomes more susceptible to osmotic pressure, leading to cell lysis and ultimately bacterial death.
Pharmacodynamics
Inhibition of transpeptidation results in the disruption of the structure and integrity of the bacterial cell wall. This weakens the wall, making the bacterium more susceptible to osmotic pressure changes.
Pharmacokinetics
Absorption
ceforanide is well-absorbed when administered intravenously.
Distribution
ceforanide distributes widely throughout the body.
Metabolism
ceforanide is not significantly metabolized in the body.
Elimination and excretion
ceforanide is excreted via kidneys.
Administration
ceforanide is administered intravenously (IV) or intramuscularly (IM).
It is also available in oral formulations in form of tablet.
Patient information leaflet
Generic Name: ceforanide
Why do we use ceforanide?
ceforanide is effective against skin and soft tissue infections, such as cellulitis and wound infections.
ceforanide can be used to treat uncomplicated urinary tract infections, including cystitis and pyelonephritis.
ceforanide may be used in the treatment of bone and joint infections.
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