2025 Guidelines for the Evaluation and Management of Adults With Congenital Heart Disease
December 19, 2025
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Brand Name :
Alipidem, Cerolip, Cetaxin, Cibrato, Cipide, Fixeril
Synonyms :
ciprofibrate, Ciprofibrato
Class :
Fibrates, Dyslipidaemic Agents, Lipid Modifying agents, Fibrate Antilipidemic Agent, Fibric Acid
Brand Name :
Alipidem, Cerolip, Cetaxin, Cibrato, Cipide, Fixeril
Synonyms :
ciprofibrate, Ciprofibrato
Class :
Fibrates, Dyslipidaemic Agents, Lipid Modifying agents, Fibrate Antilipidemic Agent, Fibric Acid
Dosage Forms & Strengths
Tablet
100 mg
It is used in the therapy for Hyperlipidaemia with a recommended dose of 100 mg via oral administration taken per day
Dose Adjustments
Renal dose adjustment
In case of renal impairment, dose of ciprofibrate depends on CrCl. When CrCl falls between 30 and 80 ml/min dose of ciprofibrate reduced to 100 mg every alternate day. If CrCl is less than 30 ml/min, ciprofibrate is contraindicated
It is used in the therapy for Hyperlipidaemia with a recommended dose of 100 mg via oral administration taken per day
Dose Adjustments
Renal dose adjustment
In case of renal impairment, dose of ciprofibrate depends on CrCl. When CrCl falls between 30 and 80 ml/min dose of ciprofibrate reduced to 100 mg every alternate day. If CrCl is less than 30 ml/min, ciprofibrate is contraindicated
Safety and efficacy are not seen in pediatrics
Refer to the adult dosing
may diminish the absorption when combined with fibric acid derivatives
may increase the adverse effect of HMG-CoA Reductase Inhibitors
may increase the nephrotoxic effect of cyclosporine
may diminish the absorption when combined with fibric acid derivatives
it increases the toxicity of fibric derivatives
it increases the toxicity of fibric derivatives
it increases the toxicity of fibric derivatives
it increases the toxicity of fibric derivatives
it increases the toxicity of fibric derivatives
may intensify the potentially negative effects of HMG-CoA Reductase Inhibitors
fibric acid derivatives increase the toxicity of ezetimibe
may have an increased hypoglycemic effect when combined with sulfonylureas
may have an increased hypoglycemic effect when combined with sulfonylureas
may have an increased hypoglycemic effect when combined with sulfonylureas
may have an increased hypoglycemic effect when combined with sulfonylureas
may have an increased hypoglycemic effect when combined with sulfonylureas
may have an increased hypoglycemic effect when combined with sulfonylureas
may have an increased hypoglycemic effect when combined with sulfonylureas
ciprofibrate: it may enhance the serum concentration of HMG-CoA Reductase Inhibitors
ciprofibrate: it may enhance the serum concentration of HMG-CoA Reductase Inhibitors
ciprofibrate: it may enhance the serum concentration of HMG-CoA Reductase Inhibitors
ciprofibrate: it may enhance the serum concentration of HMG-CoA Reductase Inhibitors
ciprofibrate: it may enhance the serum concentration of HMG-CoA Reductase Inhibitors
may enhance the myopathic effect of colchicine
may increase the myopathic effect of Fibric Acid Derivatives
it increases the effect of myopathy on fibric acid derivatives
It may enhance the risk of adverse effects when combined with Atypical Antidepressants
It may enhance the risk of adverse effects when combined with Atypical Antidepressants
It may enhance the risk of adverse effects when combined with Atypical Antidepressants
when ciprofibrate is given along with acenocoumarol, there is an increased risk of bleeding
when ciprofibrate is given along with acenocoumarol, there is an increased risk of bleeding
when ciprofibrate is given along with warfarin, there is an increased risk of bleeding
there is an increased risk of myopathy, myoglobinuria, and rhabdomyolysis when vincristine is combined with ciprofibrate
Actions and Spectrum:
Actions:
Fibric acid derivative, ciprofibrate, has hypolipidemic action that is marked, which is shown by increasing HDL cholesterol levels and by reducing LDL and VLDL cholesterol levels, which further leads to reduced triglyceride levels.
Spectrum:
The hyperlipidemic action of ciprofibrate shows its spectrum of activity in the treatment of hyperlipidemia (severe or mixed) and hypertriglyceridemia.
Frequency not defined
alopecia
anorexia
diarrhoea
urticaria
eczema
myalgia
peripheral neuropathy
pulmonary fibrosis
pancreatitis
leukocytopenia
impotence
cytolysis
rashes
myositis
headache
elevated CPK levels
headache
photosensitivity
dyspepsia
vomiting
nausea
abdominal pain
dizziness
rhabdomyolysis
thrombocytopenia
fatigue
pneumonitis
somnolence
Black Box Warning:
Driving or operating machinery should be avoided while on ciprofibrate as it may cause dizziness. Smoking and alcohol should be stopped while taking this medication.
Contraindication/Caution:
Contraindications
Cautions
Pregnancy consideration:
ciprofibrate is contraindicated in first trimester of pregnancy and should be avoided.
Breastfeeding warnings:
No published data is available.
Pregnancy category:
Category A: well-controlled and satisfactory studies show no risk to the fetus in the first or later trimester.
Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.
Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.
Category N: No data is available for the drug under this category.
Pharmacology:
The hyperlipidemic action of ciprofibrate shows its spectrum of activity in the treatment of hyperlipidemia (severe or mixed) and hypertriglyceridemia. When cholesterol and triglyceride levels are high, ciprofibrate is used to reduce those levels by speeding or increasing the rate of metabolism of fats.
Pharmacodynamics:
When cholesterol and triglyceride levels are high, ciprofibrate is used to reduce those levels by speeding or increasing the rate of metabolism of fats. Fibric acid derivative, ciprofibrate, has hypolipidemic action that is marked, which is shown by increasing HDL cholesterol levels and by reducing LDL and VLDL cholesterol levels, which further leads to reduced triglyceride levels.
Pharmacokinetics:
Absorption
ciprofibrate is readily absorbed from the GIT.
The time to achieve peak effect is 1-4 hours
Distribution
Protein-bound is 98%
Metabolism
Limited data available.
Elimination and Excretion
The half-life is 38-86 hours.
The drug is excreted via urine as glucuronide conjugates and as unchanged drug.
Administration:
Oral Administration of ciprofibrate can be taken with or without food. Some people will swallow the tablet while drinking water. The usual dose recommended is 100 mg per day.
Patient information leaflet
Generic Name: ciprofibrate
Pronounced: SIGH-proh-fye-brayt
Why do we use ciprofibrate?
When cholesterol and triglyceride levels are high, ciprofibrate is used to reduce those levels by speeding or increasing the rate of metabolism of fats.
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