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Brand Name :
Striatran
Synonyms :
emylcamate
Class :
Anti-anxiety agents
Brand Name :
Striatran
Synonyms :
emylcamate
Class :
Anti-anxiety agents
Dosage forms and strengths Â
Oral Tablet Â
400 mgÂ
200 mgÂ
In vivo data suggests taking 200 mg-400 mg orally every eight hours or every six hours a day
Not indicatedÂ
Refer adult dosingÂ
When emylcamate is used together with acetazolamide, this leads to enhanced risk or seriousness of CNS depression
When emylcamate is used together with acetophenazine, this leads to enhanced risk or seriousness of CNS depression
When emylcamate is used together with agomelatine, this leads to enhanced risk or seriousness of CNS depression
When emylcamate is used together with alfentanil, this leads to enhanced risk or seriousness of CNS depression
When emylcamate is used together with alimemazine, this leads to enhanced risk or seriousness of CNS depression
When emylcamate is used together with almotriptan ,this leads to enhanced risk or seriousness of CNS depression
When emylcamate is used together with alostetron, this leads to enhanced risk or seriousness of CNS depression
When emylcamate is used together with alprazolam, this leads to enhanced risk or seriousness of CNS depression
When emylcamate is used together with amisulpride, this leads to enhanced risk or seriousness of CNS depression
When emylcamate is used together with amitriptyline, this leads to enhanced risk or seriousness of CNS depression
When emylcamate is used together with amobarbital, this leads to enhanced risk or seriousness of CNS depression
When emylcamate is used together with amoxapine, this leads to enhanced risk or seriousness of CNS depression
When emylcamate is used together with apomorphine, this leads to enhanced risk or seriousness of CNS depression
When emylcamate is used together with aripiprazole, this leads to enhanced risk or seriousness of CNS depression
When emylcamate is used together with articaine, this leads to enhanced risk or seriousness of CNS depression
When emylcamate is used together with asenapine, this leads to enhanced risk or seriousness of CNS depression
When emylcamate is used together with atracurium, this leads to enhanced risk or seriousness of CNS depression
When emylcamate is used together with benperidol, this leads to enhanced risk or seriousness of CNS depression
When emylcamate is used together with benzocaine, this leads to enhanced risk or seriousness of CNS depression
When emylcamate is used together with benzphetamine, this leads to enhanced risk or seriousness of CNS depression
When emylcamate is used together with benzyl alcohol, this leads to enhanced risk or seriousness of CNS depression
When emylcamate is used together with brexanolone, this leads to enhanced risk or seriousness of CNS depression
When emylcamate is used together with brexpiprazole, this leads to enhanced risk or seriousness of CNS depression
When emylcamate is used together with brivaracetam, this leads to enhanced risk or seriousness of CNS depression
When emylcamate is used together with bromazepam, this leads to enhanced risk or seriousness of CNS depression
When emylcamate is used together with bromocriptine, this leads to enhanced risk or seriousness of CNS depression
When emylcamate is used together with brompheniramine, this leads to enhanced risk or seriousness of CNS depression
When emylcamate is used together with bupivacaine, this leads to enhanced risk or seriousness of CNS depression
When emylcamate is used together with bupropion, this leads to enhanced risk or seriousness of CNS depression
When emylcamate is used together with buspirone, this leads to enhanced risk or seriousness of CNS depression
When emylcamate is used together with butabarbital, this leads to enhanced risk or seriousness of CNS depression
When emylcamate is used together with butalbital, this leads to enhanced risk or seriousness of CNS depression
When emylcamate is used together with butorphanol, this leads to enhanced risk or seriousness of CNS depression
When emylcamate is used together with butriptyline, this leads to enhanced risk or seriousness of CNS depression
When emylcamate is used together with cabergoline, this leads to enhanced risk or seriousness of CNS depression
When emylcamate is used together with carbamazepine, this leads to enhanced risk or seriousness of CNS depression
When emylcamate is used together with carbinoxamine, this leads to enhanced risk or seriousness of CNS depression
When emylcamate is used together with cariprazine, this leads to enhanced risk or seriousness of CNS depression
When emylcamate is used together with cetirizine, this leads to enhanced risk or seriousness of CNS depression
When emylcamate is used together with chlordiazepoxide, this leads to enhanced risk or seriousness of CNS depression
When emylcamate is used together with chloroprocaine, this leads to enhanced risk or seriousness of CNS depression
When emylcamate is used together with chlorpheniramine, this leads to enhanced risk or seriousness of CNS depression
When emylcamate is used together with chlorpromazine, this leads to enhanced risk or seriousness of CNS depression
When emylcamate is used together with chlorprothixene, this leads to enhanced risk or seriousness of CNS depression
When emylcamate is used together with chlorzoxazone, this leads to enhanced risk or seriousness of CNS depression
When emylcamate is used together with cinchocaine, this leads to enhanced risk or seriousness of CNS depression
When emylcamate is used together with cisapride , this leads to enhanced risk or seriousness of CNS depression
When emylcamate is used together with clemastine, this leads to enhanced risk or seriousness of CNS depression
When emylcamate is used together with clomipramine, this leads to enhanced risk or seriousness of CNS depression
When emylcamate is used together with clonazepam, this leads to enhanced risk or seriousness of CNS depression
When emylcamate is used together with clotiazepam, this leads to enhanced risk or seriousness of CNS depression
When emylcamate is used together with clozapine, this leads to enhanced risk or seriousness of CNS depression
When emylcamate is used together with codeine, this leads to enhanced risk or seriousness of CNS depression
When emylcamate is used together with cyclizine, this leads to enhanced risk or seriousness of CNS depression
When emylcamate is used together with cyclobenzaprine, this leads to enhanced risk or seriousness of CNS depression
When emylcamate is used together with cyproheptadine, this leads to enhanced risk or seriousness of CNS depression
When emylcamate is used together with dantrolene, this leads to enhanced risk or seriousness of CNS depression
When emylcamate is used together with daridorexant, this leads to enhanced risk or seriousness of CNS depression
When emylcamate is used together with decamethonium, this leads to enhanced risk or seriousness of CNS depression
When emylcamate is used together with desflurane, this leads to enhanced risk or seriousness of CNS depression
When emylcamate is used together with diazepam, this leads to enhanced risk or seriousness of CNS depression
When emylcamate is used together with dezocine, this leads to enhanced risk or seriousness of CNS depression
When emylcamate is used together with dextromethorphan, this leads to enhanced risk or seriousness of CNS depression
When emylcamate is used together with dexbrompheniramine, this leads to enhanced risk or seriousness of CNS depression
When emylcamate is used together with desloratadine, this leads to enhanced risk or seriousness of CNS depression
When emylcamate is used together with desipramine, this leads to enhanced risk or seriousness of CNS depression
Actions and Spectrum:Â
Emylcamate’s mechanism of action involves increasing the effects of GABA at GABA-A receptors, which are ion channels responsible for inhibiting the excitability of neurons. By enhancing GABA’s action at these receptors, emylcamate promotes the opening of chloride channels, which leads to hyperpolarization of the cell membrane. This hyperpolarization inhibits the transmission of nerve signals, resulting in a sedative and calming effect on the central nervous system.Â
Frequency not defined Â
Headache  Â
Dizziness Â
VomitingÂ
Nausea Â
Black Box Warning:Â Â
None
Contraindication/Caution:Â Â
Hypersensitivity or Allergy: Individuals with a known hypersensitivity or allergy to emylcamate or any of its components should avoid its use.Â
Severe Respiratory Conditions: Emylcamate may depress respiratory function, so it should be avoided in individuals with severe respiratory disorders or compromised breathing.Â
Liver or kidney disease: Emylcamate is metabolized in the liver and excreted by the kidneys. Therefore, individuals with severe liver or kidney impairment may experience complications with the medication and should avoid its use or require dosage adjustments under medical supervision.Â
History of Substance Abuse: Due to its potential for abuse and addiction, individuals who have a past involving alcohol or drug abuse or dependence are advised to refrain from using emylcamate.Â
Pregnancy and Breastfeeding: Emylcamate may pose risks to the fetus during pregnancy and may pass into breast milk, potentially affecting the nursing infant. Therefore, it’s generally contraindicated during pregnancy and breastfeeding unless the benefits outweigh the risks and under strict medical supervision.Â
Â
Pregnancy warnings:    Â
Pregnancy category: N/AÂ
Lactation: Excreted into human milk is unknownÂ
Pregnancy Categories:        Â
Category A: Studies that were well-controlled and met expectations revealed no risk to the fetus in either the first or second trimester.Â
Category B: There were a lack of studies on pregnant women and no evidence of risk to the fetus in animal experiments.  Â
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.   Â
Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.  Â
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.   Â
Category N: There is no data available for the drug under this category
Pharmacology: Emylcamate is a sedative and anxiolytic drug that was previously used in the treatment of anxiety and tension.Â
Pharmacodynamics:Â Â
Emylcamate primarily operates by boosting the functionality of the neurotransmitter gamma-aminobutyric acid within the central nervous system to induce its pharmacological effects.It acts as a positive allosteric modulator at GABA-A receptors, which results in an increase in the inhibitory actions of GABA. This leads to neuronal hyperpolarization, decreased neuronal excitability, and ultimately produces sedative and anxiolytic effects. Â
Pharmacokinetics:Â
AbsorptionÂ
Emylcamate is typically administered orally in tablet or capsule form. It is absorbed in the gastrointestinal tract, and its absorption can be affected by food intake and other medications.Â
DistributionÂ
Once absorbed, emylcamate distributes throughout the body via the bloodstream. It crosses the blood-brain barrier and distributes into various tissues, including the central nervous system (CNS), where it exerts its sedative effects.Â
MetabolismÂ
Emylcamate undergoes hepatic metabolism (metabolism in the liver) primarily through the cytochrome P450 (CYP450) enzyme system. It is metabolized into inactive compounds before being eliminated from the body.Â
Excretion and EliminationÂ
The metabolites of emylcamate and a small portion of unchanged drug are eliminated mainly through the urine. The elimination half-life of emylcamate can vary among individuals and ranges from several hours to around a day.Â
Administration: Â
Emylcamate was commonly available in tablet form. It was usually taken orally with or without food.Â
Patients were instructed to adhere precisely to their healthcare provider’s prescription for the medication and avoid exceeding the recommended dosage or treatment duration.Â
Patient information leafletÂ
Generic Name: emylcamateÂ
Why do we use emylcamate? Â
Emylcamate was utilized to alleviate symptoms of anxiety disorders. It acted as a tranquilizer, helping individuals manage feelings of unease or nervousness.Â
It was prescribed to relieve muscular tension, especially in cases where tension was related to anxiety or stress. Emylcamate was sometimes used as a sleep aid for short-term treatment of insomnia. It could help individuals fall asleep or improve sleep quality.Â
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