Anthropometric Measurements as Predictors of Low Birth Weight Among Tanzanian Neonates: A Hospital-Based Study
November 7, 2025
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Brand Name :
Xerava
(United States) [Available]Synonyms :
eravacycline
Class :
Tetracyclines
Brand Name :
Xerava
(United States) [Available]Synonyms :
eravacycline
Class :
Tetracyclines
Dosage Forms & Strengths  Â
Injection- lyophilized powder for reconstitution: Â
50mg per single-dose vial   Â
1
mg/kg
Intravenous (IV)
every 12 hrs
4 - 14
days
Dose Adjustments
Renal Dose Adjustments:
No adjustment required
Liver Dose Adjustments:
No adjustment is recommended for Mild to moderate liver dysfunction
Severe liver dysfunction (Child-Pugh C):
1 mg/kg IV every 12 hours on 1st day
1 mg/kg IV every 24 hours on the 2nd day
maximum duration of treatment is 4-14 days
CYP3A4 inducers: they may diminish the serum concentration of eravacycline
CYP3A4 inducers: they may diminish the serum concentration of eravacycline
CYP3A4 inducers: they may diminish the serum concentration of eravacycline
CYP3A4 inducers: they may diminish the serum concentration of eravacycline
CYP3A4 inducers: they may diminish the serum concentration of eravacycline
eravacycline: it may increase the risk of methemoglobinemia associated agents
eravacycline: it may increase the risk of methemoglobinemia associated agents
eravacycline: it may increase the risk of methemoglobinemia associated agents
eravacycline: it may increase the risk of methemoglobinemia associated agents
eravacycline: it may increase the risk of methemoglobinemia associated agents
When both drugs are combined, there may be a reduced therapeutic effect of amoxicillin
When both drugs are combined, there may be a reduced therapeutic effect of ampicillin sodium sulfate/potassium sulfate/magnesium
When both drugs are combined, there may be decreased levels of eravacycline by inhibition of GI absorption
Therapeutic efficacy of azlocillin may decrease.
CYP3A strong enhancers of the small intestine may reduce the bioavailability of eravacycline 
lansoprazole amoxicillin and clarithromycin
when amoxicillin combines with eravacycline it decreases the effects of action of drug by antagonism effect
amoxicillin and clavulanate potassium
when amoxicillin combines with eravacycline it decreases the effects of action of drug by antagonism effect
when both drugs are combined, there may be a decreased effect of the drug's action by antagonism effect
When both drugs are combined, there may be an increased risk of adverse effects
When both drugs are combined, there may be an increased risk of adverse effects
may enhance the risk of adverse effect of retinoic acid derivatives
may enhance the risk of adverse effect of retinoic acid derivatives
may enhance the risk of adverse effect of retinoic acid derivatives
may enhance the risk of adverse effect of retinoic acid derivatives
eravacycline: it may increase the therapeutic efficacy of with pheneticillin
The interaction may depress the therapeutic efficacy of tetracyclines
Eravacycline belongs to the class of antibacterial medications known as tetracyclines and is a fluorocycline.Â
Because eravacycline binds to the 30S ribosomal subunit and stops amino acid residues from being incorporated into elongating peptide chains, it interferes with the production of proteins by bacteria.Â
Adverse drug reactions: Â
1-10% Â
Diarrhea  Â
Hypotension  Â
Infusion site reactions  Â
Nausea Â
Vomiting Â
Wound dehiscence  Â
<1% Â
Acute pancreatitis, pancreatic necrosis Â
Chest pain Â
Hypersensitivity Â
Palpitations Â
NoneÂ
Contraindication:Â
HypersensitivityÂ
Caution:Â
Avoid with history of tetracycline allergy Â
Allergic reactionÂ
Use while the teeth are still developing could result in permanent tooth discolouration.Â
Pregnancy warnings:   Â
Breastfeeding warnings:Â
Pregnancy Categories:     Â
By binding the 30S ribosomal subunit, it inhibits the incorporation of amino acid residues into elongating peptide chainsÂ
A broad spectrum of gram-positive and gram-negative bacteria, including those that are resistant to many drugs, are susceptible to eravacycline’s action.Â
Eravacycline is structurally altered to circumvent common tetracycline resistance mechanisms, and it is not much impacted by ribosome protection proteins or efflux pumps, which usually make previous tetracyclines ineffective.Â
Intravenous administration infuses over ~60 minutes.Â
It may be administered IV through dedicated line or Y-site.Â
If multiple medications are infused sequentially into the same IV-line, flush with 0.9% NaCl both before and after the eravacycline infusion.Â
Patient Information Leaflet Â
Generic Name: eravacycline (Rx) Â
Pronounced: ER-a-va-SYE-kleenÂ
 Â
Why do we use eravacycline?
Eravacycline is indicated for the treatment of complicated intra-abdominal infections.Â
It is effective against a broad range of gram-positive, gram-negative, aerobic, and anaerobic bacteria.Â
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