A Framework for Fitness-for-Purpose and Reuse in Computational Phenotyping
November 17, 2025
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Brand Name :
Florinef, florinef acetate
Synonyms :
fludrocortisone
Class :
corticosteroids
Brand Name :
Florinef, florinef acetate
Synonyms :
fludrocortisone
Class :
corticosteroids
Dosage Forms & Strengths
Tablet
0.1mg
Indicated for adrenocortical insufficiency:
0.1mg orally/day
Maintenance dose:0.1mg orally weekly thrice to 0.2mg orally per day
Congenital Adrenal Hyperplasia
0.1-0.2mg/day orally
Dosage Forms & Strengths
Tablet
0.1mg
Not approved by the FDA for use in children
Addison disease/adrenocortical insufficiency
0.05mg to 0.1mg orally/day
Indicated for adrenocortical insufficiency:
0.05mg-0.1mg orally/day
Congenital Adrenal Hyperplasia
0.05-0.3mg/day orally
Refer adult dosing
may increase the immunosuppressive effect of corticosteroids
may increase the immunosuppressive effect of corticosteroids
may increase the immunosuppressive effect of corticosteroids
may decrease the therapeutic effect
may decrease the therapeutic effect
may decrease the therapeutic effect
may decrease the therapeutic effect
may decrease the therapeutic effect
may increase the immunosuppressive effect of corticosteroids
may decrease the therapeutic effect of corticosteroids
may decrease the therapeutic effect of corticosteroids
may decrease the therapeutic effect of corticosteroids
may decrease the therapeutic effect of corticosteroids
may decrease the therapeutic effect of corticosteroids
may increase the immunosuppressive effect of corticosteroids
When fludrocortisone is used in combination with rabies vaccine, this leads to a reduction in the rabies vaccine effects through the process of pharmacodynamic antagonism
when fludrocortisone is used in combination with diphtheria & tetanus toxoids, this leads to a reduction in the effects of diphtheria & tetanus toxoids through pharmacodynamic antagonism
may diminish the therapeutic effect of aldosterone antagonist
may increase the toxic effect of corticosteroids
may increase the toxic effect of corticosteroids
may increase the toxic effect of corticosteroids
may increase the toxic effect of corticosteroids
may increase the toxic effect of corticosteroids
relugolix/estradiol/norethindrone
may increase the fluid-retaining effect of corticosteroids
relugolix/estradiol/norethindrone
may increase the fluid-retaining effect of corticosteroids
may increase the fluid-retaining effect of corticosteroids
may increase the fluid-retaining effect of corticosteroids
may increase the fluid-retaining effect of corticosteroids
may decrease the therapeutic effect of corticosteroids
may increase the serum concentration
bazedoxifene/conjugated estrogens
may increase the serum concentration
may increase the serum concentration
may increase the serum concentration
may increase the serum concentration
may decrease the therapeutic effect of corticosteroids
may decrease the therapeutic effect of corticosteroids
may decrease the therapeutic effect of corticosteroids
may decrease the therapeutic effect of corticosteroids
may increase the hypokalemic effect of corticosteroids
may increase the hypokalemic effect of corticosteroids
may increase the hypokalemic effect of corticosteroids
may increase the anticoagulant effect
may increase the anticoagulant effect
may increase the anticoagulant effect
may increase the anticoagulant effect
may increase the anticoagulant effect
It may enhance the risk of adverse effects when combined with Mineralocorticoids
It may enhance the risk of adverse effects when combined with Mineralocorticoids
When fludrocortisone is used together with ridaforolimus, this leads to enhanced concentration serum of fludrocortisone
When fludrocortisone is used in combination with profenamine, this leads to reduction in therapeutic effectiveness of profenamine
the activity of the anthrax vaccine can be reduced when used in combination with fludrocortisone
may increase the risk or severity of toxic effects when combined
When fludrocortisone is used together in combination with profenamine, this leads to reduction in therapeutic effectiveness of profenamine
the activity of the anthrax vaccine can be reduced when used in combination with fludrocortisone
When fludrocortisone is aided by androstenediol, that promotes an increased risk of edema
It works by stimulating the mineralocorticoid receptors located in the kidney which leads to an increase in the activity of the sodium and potassium pump known as sodium potassium ATPase. It also enhances the reabsorption of sodium and potassium, which leads to an increase in blood volume and consequently, the blood pressure.
It is used for conditions associated with low levels of aldosterone in the body for instance adrenal insufficiency also known as Addison’s disease and hypoaldosteronism. It is also employed for the management of salt-losing congenital adrenal hyperplasia and as part of the hormone replacement therapy in congenital adrenal hyperplasia.
Frequency undefined
Adrenal suppression
Delayed wound healing
GI perforation
Hepatomegaly
Increased transaminases
Menstrual regularity
Peptic ulcer
Psychosis
Vertigo
Acne
Diabetes mellitus
Glucose intolerance
Insomnia
Myopathy
Osteoporosis
Seizure
Black box warning
None
Contraindications/caution
Contraindications
Caution
Pregnancy/Lactation
Pregnancy consideration: C
Lactation: Excretion of the drug in human breast milk is unknown
Pregnancy category:
Pharmacology
It is a mineralocorticoid and glucocorticoid hormone which is associated with the drug’s capacity to influence the concentrations of electrolytes and water, thereby maintaining electrolyte homeostasis. Fludrocortisone aids in maintaining blood pressure and fluid quantity in the body by encouraging higher sodium reabsorption and potassium excretion from distal renal tubules. It also exerts glucocorticoid effects involved in inflammation and immune response suppression. Fludrocortisone is used in the management of a wide range of health conditions including adrenal insufficiency, Addison’s disease, hypotension and electrolyte disorders.
Pharmacodynamics
The mechanism of action fludrocortisone is associated with the stimulation of the mineralocorticoid and glucocorticoid receptors within the body. It is a synthetic mineralocorticoid which increases the accumulation of sodium in the body and potassium ions are excreted in the distal renal tubules. This helps in the control of blood pressure as well as distribute fluids throughout the body.
Pharmacokinetics
Absorption
It is well absorbed with a bioavailability of 100% following oral administration. The peak plasma time is usually less than or equal to 1.7 hours
Distribution
It is widely distributed throughout the body and is 42% protein-bound
Metabolism
It is primarily metabolized in the liver
Elimination/Excretion
Half-life is approximately 3.5 hours
Biological half-life is 18 to 36 hours. It is mainly excreted through the kidneys as metabolites
Administration
It can also be in the form of a liquid or an injectable but normally it is taken orally as a tablet
Patient information leaflet
Generic Name: fludrocortisone
Pronounced: [ FLOO-droe-KOR-ti-sone ]
Why do we use fludrocortisone?
Fludrocortisone is a corticosteroid, and it is used in the treatment of Addison’s disease which is a condition whereby the adrenal glands do not produce enough cortisol and aldosterone hormones. It is also used to manage a disease known as adrenogenital syndrome which is a condition that leads to inability of the body to retain salt and water. It is employed in the management of these conditions, to supplement the lacking hormone within the body, in addition to assisting in the maintenance of electrolyte equilibrium.
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