Fame and Mortality: Evidence from a Retrospective Analysis of Singers
November 26, 2025
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Brand Name :
vimpat
Synonyms :
Class :
Anti-convulsant
Brand Name :
vimpat
Synonyms :
Class :
Anti-convulsant
Dosage Forms & Strengths
Tablet-Schedule V:
50mg,100mg,150mg,200mg
Injectable solution-Schedule V:
200mg/20ml
Oral solution-Schedule V:
10mg/ml
Monotherapy:
IV/Orally:100mg every 12 hours initially;
Increase by 50mg twice daily up to 150-200mg twice a day
Alternate initial dosing schedule:
IV/Orally:200mg initially followed 12 hours later by 100mg
Increase by 50mg twice daily up to 150-200mg twice a day
Adjunctive therapy:
IV/Orally:50mg every 12 hours
Increase by 50mg twice daily up to 100-200mg twice a day
Dosage forms and strength:
Tablet-Schedule V:
50mg,100mg,150mg,200mg
Injectable solution-Schedule V:
200mg/20ml
Oral solution-Schedule V:
10mg/ml
IV/Orally:50mg every 12 hours
Increase by 50mg weekly intervals up to 100-200mg twice a day
Dose Adjustments
Renal impairment:
CrCl ≥30 mL/minute: Initial and maintenance: No dosage adjustment is necessary
CrCl <30 mL/minute:
Initial: No dosage adjustment necessary; use caution in maintenance dose
Hepatic impairment:
Mild to moderate: no dosage adjustment is necessary
Severe: Not recommended
<1 month: Safety and efficacy not established
One month to 17 years
<6 kg:
IV:0.66 mg/kg thrice a day; increase the weekly dose by 0.66mg/kg-recommended dose-2.5-5mg/kg.
Oral: 1 mg/kg twice daily; increase the weekly dose by 1 mg/kg up to 3.75-7.5mg/kg.
6 to <30kg:
1 mg/kg orally/IV twice daily; increase the weekly dose by 1 mg/kg up to 3-6mg/kg.
30 to <50kg:
1 mg/kg orally/IV twice daily; increase weekly dose by 1 mg/kg up to 2-4mg/kg.
Refer adult dosing
spironolactone and hydrochlorothiazide
may enhance the toxic effects of the other by pharmacodynamic synergism
may enhance the toxic effects of the other by pharmacodynamic synergism
may enhance the toxic effects of the other by pharmacodynamic synergism
may enhance the toxic effects of the other by pharmacodynamic synergism
may enhance the toxic effects of the other by pharmacodynamic synergism
may increase the level by affecting hepatic enzyme CYP3A4 metabolism
may decrease the level by affecting hepatic enzyme CYP3A4 metabolism
may increase the level by affecting the hepatic enzyme CYP3A4 metabolism
may decrease the level by affecting hepatic enzyme CYP2C9 metabolism
it may increase the effects of each other
may increase the risk of sedation
may increase the level by affecting hepatic enzyme CYP3A4 metabolism
may increase the level by affecting hepatic enzyme CYP3A4 metabolism
may increase the adverse or toxic effect of anti-psychotic agents
may increase the adverse or toxic effect of anti-psychotic agents
may increase the adverse or toxic effect of anti-psychotic agents
may increase the adverse or toxic effect of anti-psychotic agents
may increase the adverse or toxic effect of anti-psychotic agents
may increase the adverse or toxic effect of anti-psychotic agents
may increase the adverse or toxic effect of anti-psychotic agents
may increase the adverse or toxic effect of anti-psychotic agents
may increase the adverse or toxic effect of anti-psychotic agents
may increase the adverse or toxic effect of anti-psychotic agents
may increase the adverse or toxic effect of anti-psychotic agents
may increase the adverse or toxic effect of anti-psychotic agents
may increase the adverse or toxic effect of anti-psychotic agents
may increase the adverse or toxic effect of anti-psychotic agents
may increase the adverse or toxic effect of anti-psychotic agents
may increase the adverse or toxic effect of anti-psychotic agents
may increase the adverse or toxic effect of anti-psychotic agents
may increase the adverse or toxic effect of anti-psychotic agents
may enhance the adverse/toxic effect of lacosamide
may enhance the adverse/toxic effect of lacosamide
may enhance the adverse/toxic effect of lacosamide
may enhance the adverse/toxic effect of lacosamide
may enhance the adverse/toxic effect of lacosamide
may decrease the level by affecting hepatic enzyme CYP2C9 metabolism
May enhances the effects of the other by pharmacodynamic synergism
may increase the level by affecting hepatic enzyme CYP2C9 metabolism
may increase the level by affecting hepatic enzyme CYP3A4 metabolism
may increase the level by affecting hepatic enzyme CYP3A4 metabolism
may decrease the level by affecting hepatic enzyme CYP3A4 metabolism
may decrease the level by affecting the hepatic enzyme CYP3A4 metabolism
may increase the level by affecting hepatic enzyme CYP3A4 metabolism
may increase the level by affecting hepatic enzyme CYP3A4 metabolism
may increase the level by affecting hepatic enzyme CYP2C9 metabolism
May enhances the effects of the other by pharmacodynamic synergism
May enhances the effects of the other by pharmacodynamic synergism
may increase the level by affecting the hepatic enzyme CYP3A4 metabolism
may increase the level by affecting the hepatic enzyme CYP3A4 metabolism
When dexrabeprazole and lacosamide is used together, this leads to reduction in the dexrabeprazole’s metabolism
adverse effects or toxic effects of lacosamide are increased by antiarrhythmic agents when used in combination
adverse effects or toxic effects of lacosamide are increased by antiarrhythmic agents when used in combination
adverse effects or toxic effects of lacosamide are increased by antiarrhythmic agents when used in combination
adverse effects or toxic effects of lacosamide are increased by antiarrhythmic agents when used in combination
adverse effects or toxic effects of lacosamide are increased by antiarrhythmic agents when used in combination
when both drugs are combined, there may be a decreased level of serum concentration of lacosamide
the effect of lacosamide is increased by fluorouracil by the action on CYP2C9/10 hepatic enzyme metabolism
fedratinib increases the effect of lacosamide by altering the intestinal/ hepatic CYP3A4 enzyme metabolism
when both drugs are combined may enhance the bradycardia effect and raise blood pressure
when both drugs are combined may enhance the bradycardia effect and raise blood pressure
May diminish the effects of pharmacodynamic antagonism
may decrease the levels by unspecified interaction mechanism
May diminish the effects of pharmacodynamic antagonism
may increase the level by affecting hepatic enzyme CYP3A4 metabolism
May diminish the effects of pharmacodynamic antagonism
Frequency defined:
>10%
Tablets and oral solution
Dizziness (16-53%)
Diplopia (6-16%)
Blurred vision (2-16%)
Nausea (7-17%)
Vomiting (6-16%)
Fatigue (7-15%)
Ataxia (11-14%)
Nystagmus (2-10%)
IV
Fatigue (20-63%)
Somnolence (26-34%)
Headache (4-16%)
Diplopia (4-20%)
Nausea (14-24%)
Dry mouth (6-12%)
Vomiting (4-12%)
Fatigue (12-18%)
Chest pain (3-12%)
1-10%
Tablets and oral solution
Nystagmus (2-10%)
Memory impairment (1-6%)
Balance disorder (1-6%)
Diarrhea (3-5%)
Gait disturbance (<1-4%)
Asthenia (1-3%)
Vertigo (1-4%)
Pruritus (2-3%)
Depression (2%)
IV
Oral paresthesia (4-8%)
Oral hypoesthesia (5-8%)
Diarrhea (4-8%)
Paresthesia (4-8%)
Gait disturbance (2-8%)
Hyperhidrosis (2-8%)
Tremor (4-6%)
Abnormal coordination (3-6%)
Pruritus (4-6%)
Pregnancy consideration: The drug may cross the placenta and can be detected in the serum of the newborn.
Pregnancy category: C
Lactation: The drug is known to be excreted in the human breast milk
Pregnancy category:
Patient information leaflet
Generic Name: Lacosamide
Pronounced: (la koe’ sa mide)
Why do we use lacosamide?
Lacosamide is used to treat partial onset seizures and works by decreasing the abnormal electrical activity in the brain.
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