Anthropometric Measurements as Predictors of Low Birth Weight Among Tanzanian Neonates: A Hospital-Based Study
November 7, 2025
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Brand Name :
Thyrolar 
Synonyms :
liotrix
Class :
Thyroid Products 
Brand Name :
Thyrolar 
Synonyms :
liotrix
Class :
Thyroid Products 
Dosage forms& StrengthsÂ
Each 60 mg tablet equals 60-65 mg (1 grain) of the desicated thyroid.  Â
Liothyronine sodium (T3) is around four times as effective as levothyroxine (T4).  Â
T3/T4, tablet Â
37.5/150mcg: Thyrolar 3 (180mg) Â
25/100mcg: Thyrolar 2 (120mg) Â
12.5/50mcg: Thyrolar 1 (60mg) Â
6.25/25mcg: Thyrolar 1/2 (30mg) Â
3.1/12.5mcg: Thyrolar 1/4 (15mg) Â
1 tablet Thyrolar 1/2 daily, followed by 1 tablet Thyrolar 1/4 every 2 to 3 weeks
In long-standing myxedema, a lower initial dose of 1 tab is recommended, especially if cardiovascular damage is suspected, in which further caution is advised
Maintenance: one tablet of Thyrolar 1 to 1 tablet Thyrolar 2 daily; failure to respond to tab Thyrolar 3 can suggest a lack of compliance and malabsorption.
After necessary clinical laboratory analyses of T4 bound and free TSH blood levels, adjust the dosage within the first four weeks of therapy
Dosage Forms & Strengths Â
Each 60 mg tablet equals 60-65 mg (1 grain) of the desicated thyroid.  Â
Liothyronine sodium (T3) is around four times as effective as levothyroxine (T4).  Â
T3/T4, tablet Â
37.5/150mcg: Thyrolar 3 (180mg) Â
25/100mcg: Thyrolar 2 (120mg) Â
12.5/50mcg: Thyrolar 1 (60mg) Â
6.25/25mcg: Thyrolar 1/2 (30mg) Â
3.1/12.5mcg: Thyrolar 1/4 (15mg) Â
0 to 6 months: 3.1/12.5 to 6.25/25 orally;
6 to 12 months: 6.25/25 to 9.35/37.5 orally;
1 to 5 yrs: 9.35/37.5 to 12.5/50 mcg orally;
6- to 12 yrs: 12.5/50 to 18.75/75 mcg orally;
Above 12 yrs: more than 18.75/75 mcg orally;
Refer to the adult dosingÂ
They may diminish the serum concentration when combined with bile acid sequestrants
thyroid products decrease the concentration of cardiac glycosides in serum
thyroid products decrease the concentration of cardiac glycosides in serum
thyroid products decrease the concentration of cardiac glycosides in serum
they decrease the efficacy of sodium iodide I-131
it decreases the concentration of thyroid products in serum
may enhance the arrhythmogenic effect
may enhance the arrhythmogenic effect
may enhance the arrhythmogenic effect
may enhance the arrhythmogenic effect
l-methylfolate-pyridoxal 5′-phosphate-methylcobalamine
may decrease the levels of serum concentration
may decrease the levels of serum concentration
may decrease the levels of serum concentration
may decrease the levels of serum concentration
may decrease the levels of serum concentration
may decrease the levels of serum concentration
may decrease the levels of serum concentration
may decrease the levels of serum concentration
may decrease the levels of serum concentration
may decrease the levels of serum concentration
may decrease the levels of serum concentration
may decrease the levels of serum concentration
may enhance the risk of adverse effects
may enhance the risk of adverse effects
may enhance the risk of adverse effects
may enhance the risk of adverse effects
may enhance the risk of adverse effects
may enhance the risk of adverse effects
may enhance the risk of adverse effects
may enhance the risk of adverse effects
may enhance the risk of adverse effects
may enhance the risk of adverse effects
may enhance the risk of adverse effects
may enhance the risk of adverse effects
may enhance the risk of adverse effects
may enhance the risk of adverse effects
may enhance the risk of adverse effects
may increase the anticoagulant effect
may increase the anticoagulant effect
may increase the anticoagulant effect
may increase the anticoagulant effect
may increase the anticoagulant effect
When liotrix is used together with ouabain, this leads to reduction in liotrix excretion
may increase the arrhythmogenic affect
may diminish the serum concentration when combined with thyroid products
may decrease the serum concentration
may decrease the serum concentration
may decrease the serum concentration
may decrease the serum concentration
may decrease the serum concentration
estrogens esterified/methyltestosterone            Â
may decrease the therapeutic effect of estrogen derivatives
antacids: they may enhance the serum concentration of thyroid products
antacids: they may enhance the serum concentration of thyroid products
it decreases the concentration of thyroid products in serum
they decrease the effect of thyroid products
they decrease the effect of thyroid products
bazedoxifene/conjugated estrogens
they decrease the effect of thyroid products
they decrease the effect of thyroid products
they decrease the effect of thyroid products
it decreases the concentration of thyroid products in serum
it decreases the concentration of thyroid products in serum
it decreases the concentration of thyroid products in serum
it decreases the concentration of thyroid products in serum
thyroid products increase the effect of anticoagulation of vitamin K antagonists
thyroid products increase the effect of anticoagulation of vitamin K antagonists
thyroid products increase the effect of anticoagulation of vitamin K antagonists
thyroid products increase the effect of anticoagulation of vitamin K antagonists
thyroid products increase the effect of anticoagulation of vitamin K antagonists
may increase the absorption of Antacids
aluminum hydroxide/magnesium hydroxideÂ
may enhance the serum concentration of antacids
aluminum hydroxide/magnesium carbonateÂ
may enhance serum concentration of antacids
may decrease the levels of serum concentration of Cardiac Glycosides
may decrease the levels of serum concentration of Cardiac Glycosides
may decrease the levels of serum concentration of Cardiac Glycosides
may reduce the therapeutic effect of thyroid products
may reduce the therapeutic effect of thyroid products
cyproterone and ethinyl estradiolÂ
may decrease the therapeutic effect of Estrogen Derivatives
amiodarone: they may decrease the therapeutic effect of thyroid products
tricyclic antidepressants may become more arrhythmogenic when used with thyroid products
tricyclic antidepressants may have a more stimulatory impact when used with thyroid products
the vasoconstricting activity of felypressin may be increased
may decrease the concentration of thyroid products in serum
may decrease the concentration of thyroid products in serum
may decrease the concentration of thyroid products in serum
may decrease the concentration of thyroid products in serum
may decrease the concentration of thyroid products in serum
may decrease the concentration of thyroid products in serum
Actions and spectrum:Â
The hormones T4 and T3, made by the thyroid, are amino acid-based and are dependent on iodine for their synthesis. The main thyroid hormone that is secreted is T4; it becomes the more active T3 with the help of <i>deiodinases</i> in the peripheral tissues. T3 is responsible for the increase in the basal metabolic rate, protein synthesis alteration, and the body’s sensitivity to catecholamines like adrenaline. These hormones are the main factors in the correct development and differentiation of all human cells, as well as the regulation of protein, fat, and carbohydrate metabolism. They have the largest effect on the cellular use of energy compounds. Thyroid hormone derivatives attach to thyroid hormone receptors to induce downstream effects.Â
Black box warningÂ
Larger doses of the drug may cause life-threatening or serious adverse eventsÂ
Contraindications/CautionÂ
ContraindicationsÂ
HypersensitivityÂ
Acute myocardial infarctionÂ
Untreated adrenal insufficiencyÂ
HyperthyroidismÂ
ThyrotoxicosisÂ
CautionÂ
Cardiovascular conditionsÂ
DiabetesÂ
OsteoporosisÂ
PregnancyÂ
BreastfeedingÂ
ComorbiditiesÂ
Metabolic syndromeÂ
Autoimmune disordersÂ
Mental health conditionsÂ
Fertility and reproductive health issuesÂ
Pregnancy & breastfeeding:Â
Pregnancy consideration:Â
USFDA pregnancy category: AÂ
Breastfeeding warnings:Â
The drug is known to be excreted into human milk. Hence, it should be used with caution in lactating mothers.Â
Pregnancy category:Â
Pharmacology:Â
It is a thyroid hormone replacement therapy that is derived synthetically. It contains thyroxine, T4 (levothyroxine sodium), and triiodothyronine, T3 (liothyronine sodium) in 4:1 ratio as per weight.Â
Pharmacodynamics:Â
Thyroid hormone drugs can be naturally occurring or man-made which can contain T4, T3, or both. T4 and T3 which are built in the human thyroid gland are made through a reaction that involves iodine and the amino acid tyrosine. Liotrix is a synthetic preparation which is a combination drug of T4 and T3 in a 4:1 weight-based ratio. These hormones increase the consumption of oxygen by most cells in the body and so the basal metabolic rate is increased which consequently results in the enhanced burning of carbohydrates, lipids, proteins. They fundamentally influenced every body system and are particularly vital for the development of the central nervous system.Â
Pharmacokinetics:Â
Elimination and excretion: the drug is known to be eliminated mainly through kidneys.Â
Administration:Â
It is recommended to take this tablet orally once daily on an empty stomach at least half an hour before breakfast.Â
Patient information leafletÂ
Generic Name: liotrixÂ
Pronounced: (lie-oh-trix) Â
Why do we use liotrix?Â
Liotrix is a substitute therapy for hypothyroidism which is the ailment of the thyroid not being able to produce sufficient thyroid hormones. It provides both T4 and T3 hormones, rectifying the thyroid hormone levels, subsiding symptoms, and restoring normal thyroid function. It is most effective when patients are already on levothyroxine monotherapy but it doesn’t work properly (TSH usually remains elevated) and liothyronine (T3) is added to give immediate relief.Â
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