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Brand Name :
No Data Available.
Synonyms :
miglitol
Class :
Antidiabetics, Alpha-Glucosidase Inhibitors
Brand Name :
No Data Available.
Synonyms :
miglitol
Class :
Antidiabetics, Alpha-Glucosidase Inhibitors
Dosage forms & Strengths
Tablet
25mg
50mg
100mg
In the case of hepatic or renal impairment, no dose adjustment is required:
In this type of condition, drug is given as monotherapy or combined with sulfonylureas
Initial dose- 25 mg orally every 8 hours with meals
Maintenance dose- 50 mg orally every 8 hours; increase the dose after 4-8 weeks
Do not increase the dose more than 100 mg orally every 8 hours
Dosage forms & Strengths
Tablet
25mg
50mg
100mg
25 mg orally every 8 hours with meals
Increase the dose after 4-8 weeks
In this type of condition, drug is given as monotherapy or combined with sulfonylureas
Initial dose- 25 mg orally every 8 hours with meals
Maintenance dose- 50 mg orally every 8 hours; increase the dose after 4-8 weeks
Do not increase the dose more than 100 mg orally every 8 hours
may have an increased hypoglycemic effect when combined with insulins
may have an increased hypoglycemic effect when combined with insulins
may have an increased hypoglycemic effect when combined with insulins
may have an increased hypoglycemic effect when combined with insulins
may have an increased hypoglycemic effect when combined with insulins
may have an increased hypoglycemic effect when combined with insulins
may have an increased hypoglycemic effect when combined with insulins
may have an increased hypoglycemic effect when combined with insulins
may have an increased hypoglycemic effect when combined with insulins
may have an increased hypoglycemic effect when combined with insulins
may increase the hypoglycemic effect of sulfonylureas
excessive ethanol with miglitol alters the blood sugar level
pramlintide and miglitol increase the effect of each other due to synergism
may enhance the hypoglycemic effect
may enhance the hypoglycemic effect
may enhance the hypoglycemic effect
may enhance the hypoglycemic effect
may enhance the hypoglycemic effect
When halometasone is used together with miglitol, this leads to elevated risk or seriousness of hyperglycemia
When miglitol is used together with diazoxide, this leads to reduction in therapeutic effectiveness of miglitol
methylprednisolone hemisuccinate
When methylprednisolone hemisuccinate is aided with miglitol, this leads to elevated hyperglycemia risk
may enhance the hypoglycemic effect of Agents with blood glucose lowering effects
may enhance the hypoglycemic effect of Agents with blood glucose lowering effects
may enhance the hypoglycemic effect of Agents with blood glucose lowering effects
may enhance the hypoglycemic effect of Agents with blood glucose lowering effects
may enhance the hypoglycemic effect of Agents with blood glucose lowering effects
may increase the hypoglycemic effect
may increase the hypoglycemic effect
may increase the hypoglycemic effect
may increase the hypoglycemic effect
may increase the hypoglycemic effect
may increase the hypoglycemic effect of hypoglycemia-associated agents
have the potential to increase the hypoglycemic impact of sulfonylureas
have the potential to increase the hypoglycemic impact of sulfonylureas
have the potential to increase the hypoglycemic impact of sulfonylureas
have the potential to increase the hypoglycemic impact of sulfonylureas
Frequency defined
>10%
Flatulence
Diarrhea
Abdominal pain
1-10%
Rash
Frequency not defined
Low serum iron
Contraindication/Caution:
miglitol is an oral medication used to treat type 2 diabetes by decreasing the absorption of carbohydrates from the diet. Like all medications, miglitol has some contraindications and cautions that should be considered before prescribing or taking it. Here are some important contraindications and cautions for miglitol:
Pregnancy consideration:
Category B
Breastfeeding warnings:
Slightly excreted in breastmilk; hence miglitol is not recommended during lactation
Pregnancy category:
Pharmacology:
miglitol is an oral medication used to treat type 2 diabetes mellitus. It is classified as an alpha-glucosidase inhibitor and works by slowing down the digestion and absorption of carbohydrates in the small intestine, thereby reducing the rise in blood glucose levels after meals.
Pharmacodynamics:
miglitol’s pharmacodynamics can be summarized as follows:
Mechanism of action: miglitol works by inhibiting alpha-glucosidase enzyme, which reduces the absorption of carbohydrates and slows down the rise of blood glucose levels.
Effect on blood glucose levels: miglitol reduces the postprandial increase in blood glucose levels after meals.
Effect on insulin secretion: miglitol does not directly affect insulin secretion from the pancreas. However, by reducing the postprandial increase in blood glucose levels, miglitol may indirectly reduce the demand for insulin.
Duration of action: miglitol’s effect is relatively short-acting, with a peak effect observed 1-2 hours after administration and a duration of action of 4-6 hours.
Overall, miglitol’s pharmacodynamics make it a useful option for the management of type 2 diabetes, particularly in individuals who experience postprandial hyperglycemia.
Pharmacokinetics:
Absorption
The half-life of the drug is 2 hours
The drug is saturable and absorbed completely at 25 mg. It gets 50-70% absorbed at 100 mg
The bioavailability is 100%
The bound protein is less than 4%
Distribution
The volume of distribution is 0.18L/kg
Metabolism
No contents are metabolised
Elimination and Excretion
The drug is excreted more than 95% in the urine
Administration:
Patient information leaflet
Generic Name: miglitol
Pronounced: mig-li-tol
Why do we use miglitol?
It is used to:
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