Microplastics and Misinformation: What Science Really Says
November 12, 2025
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Brand Name :
Asnicor, AV-COR, Corand, Corflo, Dilkor, Dilnicon, Duorandil, K Cor, Korandil, Nicoduce, Nicostar, Nikoran, Zynicor
Synonyms :
nicorandil, Nicorandilum
Class :
Anti-Anginal drugs, Pyridines and derivatives, Potassium channel activators
Dosage Forms & StrengthsÂ
Tablets Â
IVÂ
5 mgÂ
10 mgÂ
20 mgÂ
The usual therapeutic dose is 10 or 20 mg orally every 12 hours daily.
Maximum dose can go up to 40 mg for every twelve hours daily.
Safety and efficacy are not seen in pediatricsÂ
Refer to the adult dosing but it is recommended to start with lower dose of 5 mg orally twice daily for every 12 hours.Â
it increases the effect of hyperkalemia of angiotensin II receptor blockers
it increases the effect of hyperkalemia of angiotensin II receptor blockers
it increases the effect of hyperkalemia of angiotensin II receptor blockers
it increases the effect of hyperkalemia of angiotensin II receptor blockers
it increases the effect of hyperkalemia of angiotensin II receptor blockers
may increase the hypotensive effect
may increase the hypotensive effect
may increase the hypotensive effect
may increase the hypotensive effect
may increase the hypotensive effect
it increases the efficacy of hypotensive agents
it increases the efficacy of hypotensive agents
it increases the efficacy of hypotensive agents
it increases the efficacy of hypotensive agents
it increases the efficacy of hypotensive agents
may have an increased hypotensive effect when combined with anti-hypertensive agents
may have an increased hypotensive effect when combined with anti-hypertensive agents
It may increase the hypotensive effect when combined with antihypertensive agents
nicorandil: they may increase the hypotensive effect when combined with blood viscosity-reducing agents
nicorandil: they may increase the hypotensive effect when combined with blood viscosity-reducing agents
nicorandil: they may increase the hyperkalemic effect of Angiotensin II Receptor Blockers
nicorandil: they may increase the hyperkalemic effect of Angiotensin II Receptor Blockers
nicorandil: they may increase the hyperkalemic effect of Angiotensin II Receptor Blockers
nicorandil: they may increase the hyperkalemic effect of Angiotensin II Receptor Blockers
nicorandil: they may increase the hyperkalemic effect of Angiotensin II Receptor Blockers
It may enhance the risk of adverse reactions when combined with Coronary Vasodilators
It may enhance the risk of adverse reactions when combined with Coronary Vasodilators
It may enhance the risk of adverse reactions when combined with Coronary Vasodilators
It may enhance the risk of adverse effects when combined with coronary vasodilators
It may enhance the risk of adverse effects when combined with coronary vasodilators
It may enhance the risk of adverse effects when combined with coronary vasodilators
It may enhance the risk of adverse effects when combined with coronary vasodilators
nicorandil: they may decrease the therapeutic effect of antipsychotics
nicorandil: they may decrease the therapeutic effect of antipsychotics
nicorandil: they may decrease the therapeutic effect of antipsychotics
nicorandil: they may decrease the therapeutic effect of antipsychotics
nicorandil: they may decrease the therapeutic effect of antipsychotics
when nicorandil is combined or used concurrently with phosphodiesterase 5 inhibitors, it can lead to a decrease in blood pressure, which is called the synergic effect
when nicorandil is combined or used concurrently with phosphodiesterase 5 inhibitors, it can lead to a decrease in blood pressure, which is called the synergic effect
when nicorandil is combined or used concurrently with phosphodiesterase 5 inhibitors, it can lead to a decrease in blood pressure, which is called the synergic effect
when nicorandil is combined or used concurrently with phosphodiesterase 5 inhibitors, it can lead to a decrease in blood pressure, which is called the synergic effect
when nicorandil is used with this subclass of drugs, it will also result in lower blood pressure
nicorandil is used with caution when dapoxetine is prescribed, as it can have reduced orthostatic tolerance
it increases the effect of hyperkalemia in potassium salts
may increase the hypotensive effect of antihypertensives
may increase the hypotensive effect of blood pressure-lowering agents
may increase the hypotensive effect of Blood Pressure Lowering Agents
may increase the vasodilatory effect
may increase the vasodilatory effect
may increase the vasodilatory effect
may increase the vasodilatory effect
may increase the vasodilatory effect
Actions and Spectrum:Â
Actions:Â
nicorandil is a anti anginal drug that has vasodilatory effect used in the treatment of angina pectoris. It has two actions one is potassium channel opening which results in hyperpolarisation of vascular membrane of the cell that results in muscle relaxation of artery leading to dilation. It also has relaxation effects on vascular smooth muscle in venous system by increasing intracellular cGMP concentration.Â
Spectrum:Â
The spectrum of nicorandil refers to the range of conditions for which it is indicated. nicorandil is used alternative to first line treatment of angina pectoris and also for patients who are intolerant to first line drugs used in the angina treatment.
Frequency Not DefinedÂ
HeadacheÂ
DizzinessÂ
DrowsinessÂ
Nausea Â
Flushing Â
Weakness Â
Rectal bleedingÂ
Vomiting Â
Tachycardia Â
Low blood pressure Â
Rash Â
Abnormal liver function Â
Mouth ulcer Â
Muscle painÂ
Black Box Warning:Â
nicorandil influences patients who drives and use machines. It decreases the motive to drive and use machines as it is having lowering blood pressure effect and also gives dizziness and also make patient feel weak. It is advisable to patients if any kind of mentioned above symptoms occur to take rest or consult nearest clinician.Â
Contraindication/Caution:Â
ContraindicationsÂ
CautionsÂ
Pregnancy consideration:Â Â
No data is available regarding the administration of the drug during pregnancy.Â
Breastfeeding warnings:Â Â
No data is available regarding the excretion of drug in breast milk.Â
Pregnancy category:Â
Category A: well-controlled and satisfactory studies show no risk to the fetus in the first or later trimester.Â
Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.Â
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.   Â
Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.   Â
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.   Â
Category N: No data is available for the drug under this category.Â
Pharmacology:Â
nicorandil is a anti anginal drug that has vasodilatory effect used in the treatment of angina pectoris. It has two actions one is potassium channel opening which results in hyperpolarisation of vascular membrane of the cell, that results in muscle relaxation of artery leading to dilation. It also has relaxation effects on vascular smooth muscle in venous system by increasing intracellular cGMP concentration.Â
Pharmacodynamics:Â
Here are the key pharmacodynamic aspects of nicorandil:
Nicorandil apart from showing its effect on coronary arteries it also decreases blood pressure which shows improved oxygen balance between myocardium and also improves blood flow. It relaxes veins and arteries that reduces chest pain and relief to the patients.Â
Pharmacokinetics:Â
AbsorptionÂ
Orally administered nicorandil is rapidly absorbed to its full capacity from GIT. Biovalaibility of nicorandil is 75% and maximum plasma concentrations (Cmax) are reached after half and hour to one hour.The bioavailability is 34%.Â
DistributionÂ
Nicorandil has equal distribution throughout the body with volume oof distribution after IV dosing is 1.04 L/kgof body weight. Plasma protein binding of nicorandil is 25%.Â
MetabolismÂ
Metabolism of nicorandil occurs in the liver by denitration. Mailnly excreted in urineÂ
Elimination and ExcretionÂ
Plasma concentrations decreased fast elimination that has t1/2 of 2 hours and slow elimination t1/2 of 12 hours after 20 mg oral intake twice a day. Â
Total body clearance of 40 – 55 L/hour occurs after IV of 4-5 mg infusion.Â
Administration:Â
Route of administration of nicorandil mostly is oral and sometimes IV also. nicorandil is taken in the morning and evening with glass full of water and remember these tablets should not be crushed or chewed but these can be made half into equal pieces. It can be taken with or without food. Main purpose of treatment with nicorandil is to treat angina pectoris alternative to first line of anti-anginal drugs.Â
Patient information leafletÂ
Generic Name: nicorandilÂ
Why do we use nicorandil?Â
nicorandil is a vasodilatory agent that used in the treatment of chest pain or angina pectoris. It is particularly used in the treatment of stable angina pectoris.Â
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