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Brand Name :
N/A
Synonyms :
patupilone
Class :
Antineoplastic agents
Brand Name :
N/A
Synonyms :
patupilone
Class :
Antineoplastic agents
Dosage forms and strengths
Injectable solution
Indicated for advanced solid tumors
The drug is investigated in phase I trial for advanced solid tumors
The administration dose is 2.5 mg/m2 is well tolerated by the patients for three weeks or six weeks off
Not indicated
Refer adult dosing
When abemaciclib is used together with patupilone, this leads to enhanced concentration serum of abemaciclib
When acalabrutinib is used together with patupilone, this leads to enhanced concentration serum of acalabrutinib
When acenocoumarol is used together with patupilone, this leads to enhanced concentration serum of acenocoumarol
When alectinib is used together with patupilone, this leads to enhanced concentration serum of alectinib
When alfentanil is used together with patupilone, this leads to enhanced concentration serum of alfentanil
When alprazolam is used together with patupilone, this leads to enhanced concentration serum of alprazolam
When aminophylline is used together with patupilone, this leads to enhanced concentration serum of aminophylline
When amiodarone is used together with patupilone, this leads to enhanced concentration serum of amiodarone
When axitinib is used together with patupilone, this leads to enhanced concentration serum of axitinib
When bicalutamide is used together with patupilone, this leads to enhanced concentration serum of bicalutamide
When bortezomib is used together with patupilone, this leads to enhanced concentration serum of bortezomib
When bosutinib is used together with patupilone, this leads to enhanced concentration serum of bosutinib
When bromocriptine is used together with patupilone, this leads to enhanced concentration serum of bromocriptine
When busulfan is used together with patupilone, this leads to enhanced concentration serum of busulfan
When cabazitaxel is used together with patupilone, this leads to enhanced concentration serum of cabazita
When cabergoline is used together with patupilone, this leads to enhanced concentration serum of cabergoline
When ceritinib is used together with patupilone, this leads to enhanced concentration serum of ceritinib
When cisapride is used together with patupilone, this leads to enhanced concentration serum of cisapride
When clomipramine is used together with patupilone, this leads to enhanced concentration serum of clomipramine
When clonidine is used together with patupilone, this leads to enhanced concentration serum of clonidine
When clozapine is used together with patupilone, this leads to enhanced concentration serum of clozapine
When cobimetinib is used together with patupilone, this leads to enhanced concentration serum of cobimetinib
Actions and Spectrum:
Action:
Microtubule Stabilization:
Patupilone binds to tubulin, stabilizing microtubules within the cell. This stabilization disrupts the dynamic equilibrium of microtubule assembly and disassembly, leading to the inhibition of cell division and inducing cell cycle arrest.
Anti-proliferative Activity: By interfering with microtubule dynamics, patupilone inhibits the replication of cells, ultimately leading to cell death or apoptosis.
Spectrum:
Solid Tumors:
It has been investigated for its effectiveness against a range of solid tumors.
Hematological Malignancies:
Some studies have explored its potential against certain blood cancers like leukemia and lymphoma.
Frequency not defined
Peripheral neuropathy
Asthenia
Dehydration
Anorexia
Abdominal pain
Vomiting
Nausea
Diarrhea
None
Contraindication/Caution:
Hypersensitivity:
The use of patupilone should be avoided by those who have a history of hypersensitivity or adverse reaction to any of its ingredients.
Hepatic disease: Patients with severe hepatic disorders may require dosage adjustments or should avoid patupilone due to potential complications.
Pregnancy & Breastfeeding: It is recommended to avoid using patupilone while pregnant or nursing due to the potential risk of harm to the infant.
Severe Allergic Reactions:
Patients who have experienced severe allergic reactions to patupilone, like taxanes or other epothilones, should use caution or avoid patupilone altogether.
Pregnancy warnings:
Pregnancy category: N/A
Lactation: Excreted into human milk is unknown Pregnancy Categories:
Category A: Studies that were well-controlled and met expectations revealed no risk to the fetus in either the first or second trimester.
Category B: There were a lack of studies on pregnant women and no evidence of risk to the fetus in animal experiments. Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies
must take care of potential risks in pregnant women.
Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.
Category N: There is no data available for the drug under this category
Pharmacology: Patupilone is a microtubule-stabilizing agent.
Pharmacodynamics: Patupilone works by binding to beta-tubulin subunits in microtubules, thereby stabilizing microtubules. This action prevents their depolymerization and disrupts the dynamic equilibrium required for normal microtubule function during cell division. Consequently, this disruption leads to cell cycle arrest in the G2/M phase and ultimately induces apoptotic cell death.
Pharmacokinetics:
Absorption It is not orally bioavailable and is usually administered intravenously.
Distribution
It is extensively distributed into tissues, including the central nervous system.
Metabolism
It is metabolized primarily in the liver, involving the cytochrome P450 system, specifically CYP3A4.
Excretion and Elimination
Elimination occurs mainly through the bile and feces.
Administration:
The administration of patupilone typically followed a specific protocol established during clinical trials.
The exact administration process, dosage, and schedule can vary depending on the specific type of cancer being treated, the patient’s health condition, and ongoing clinical trial requirements.
It is given through intravenous infusion in a clinical setting.
Patient information leaflet
Generic Name: patupilone
Why do we use patupilone? Patupilone has shown promise in the treatment of various types of cancer.
It has been investigated for its efficacy against breast cancer, ovarian cancer, lung cancer, and other solid tumors.
For patients who might not respond well to other conventional chemotherapy agents, patupilone represents a potential alternative or complementary treatment option.
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