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Brand Name :
Matulane
(United States) [Available]Synonyms :
procarbazine, procarbazina
Class :
Antineoplastics, Alkylating Agent
Brand Name :
Matulane
(United States) [Available]Synonyms :
procarbazine, procarbazina
Class :
Antineoplastics, Alkylating Agent
Dosage Forms & StrengthsÂ
CapsuleÂ
50mgÂ
Initial Dose:
2 - 4
mg/kg
Capsules
Orally 
every day
in single or divided doses for seven days
Maintenance Dose: 4 to 6 mg/kg/day orally until a maximum response is attained, or until the white blood count falls below 4000 cells/mm3 or the platelets fall below 100,000 cells/mm3
After the maximum response is obtained, the dosage may be reduced to 1 to 2 mg/kg/day orally
If it is hematologic or other toxicity, stop the treatment until a full recovery has been achieved. After considering the patient's assessment and laboratory results, the doctor may restart treatment at 1 to 2 mg/kg/day
Dosage Forms & StrengthsÂ
CapsuleÂ
50mgÂ
Dosage Forms & StrengthsÂ
CapsuleÂ
50mgÂ
may decrease the diagnostic effect of immunosuppressants
may decrease the therapeutic effect of immunosuppressants
may increase the neutropenic effect of myelosuppressive agents
may increase the immunosuppressive effect of immunosuppressants
may decrease the therapeutic effect of immunosuppressants
may decrease the therapeutic effect of immunosuppressants
poliovirus vaccine, live, trivalent
may decrease the therapeutic effect of immunosuppressants
poliovirus vaccine inactivated
may decrease the therapeutic effect of immunosuppressants
may increase the toxic effect of anti-neoplastic agents
may decrease the therapeutic effect of anti-neoplastic agents
It may enhance serotonin levels when combined with tramadol
the effects of caffeine may be enhanced with procarbazine due to synergistic action
may increase the immunosuppressive effect of immunosuppressants
it increases the effect of CNS depressants
it increases the effect of CNS depressants
it increases the effect of CNS depressants
it increases the effect of CNS depressants
it increases the effect of CNS depressants
it increases the effect of CNS depressants
may increase the CNS depressant effect
may increase the CNS depressant effect
may increase the CNS depressant effect
may increase the CNS depressant effect
may increase the CNS depressant effect
it increases the effect of CNS depressants
it increases the effect of CNS depressants
it increases the effect of CNS depressants
may increase the myelosuppressive effect of myelosuppressive agents
may increase the myelosuppressive effect of myelosuppressive agents
it increases the effect of CNS depressants
it increases the effect of CNS depressants
it increases the effect of CNS depressants
it increases the toxicity of CNS depressants
it increases the toxicity of CNS depressants
it increases the toxicity of CNS depressants
procarbazine: they may increase the CNS depressant effect of CNS Depressants
it increases the effect of CNS depressants
it increases the effect of CNS depressants
it increases the effect of CNS depressants
it increases the effect of CNS depressants
it increases the effect of CNS depressants
it increases the effect of CNS depressants
may enhance the immunosuppressive effects of each other
may increase the CNS depressant effect
may increase the CNS depressant effect
may increase the CNS depressant effect
may increase the CNS depressant effect of CNS depressants
may increase the CNS depressant effect of CNS depressants
may increase the CNS depressant effect of CNS depressants
may increase the CNS depressant effect of CNS Depressants
it increases the effect of CNS depressants
it increases the effect of CNS depressants
it increases the effect of CNS depressants
it increases the effect of CNS depressants
it increases the effect of CNS depressants
Actions and Spectrum:Â
Frequency not definedÂ
NeuropathyÂ
NauseaÂ
Pleural effusionÂ
Heinz bodiesÂ
Impairment of fertilityÂ
NeurotoxicityÂ
VomitingÂ
MyelosuppressionÂ
Hepatic dysfunctionÂ
Black box warning:Â
Contraindications/caution:Â
Contraindications:Â
Caution:Â
Pregnancy consideration: DÂ
Lactation: Excretion of the drug in human breast milk is known. Nursing is not recommended.Â
Pregnancy category:Â
Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester.  Â
Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.Â
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.   Â
Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.   Â
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.   Â
Category N: There is no data available for the drug under this categoryÂ
Pharmacology:Â
procarbazine is an alkylating agent which damages the DNA of cancer cells and prevents them from dividing and growing. Specifically, procarbazine forms a highly reactive metabolite called methyl diazomethane, which binds to DNA and inhibits replication.Â
Pharmacodynamics:Â
The pharmacodynamics of procarbazine involves its effects on the DNA of cancer cells and its impact on healthy cells in the body. procarbazine is an alkylating agent that works by binding to the DNA in cancer cells and interfering with its replication, ultimately leading to cell death. It primarily acts during the S-phase of the cell cycle.Â
procarbazine can also cause damage to healthy cells, particularly those rapidly dividing, such as blood cells in the bone marrow and cells in the gastrointestinal tract. This can result in side effects such as bone marrow suppression, nausea and vomiting, and gastrointestinal toxicity. procarbazine can also cause nervous system toxicity, leading to symptoms such as dizziness, confusion, and seizures.Â
Pharmacokinetics:Â
AbsorptionÂ
procarbazine is orally in capsule form and rapidly absorbed from the gastrointestinal tract. The peak plasma concentration is typically achieved within one hour of administration. Â
DistributionÂ
procarbazine is highly protein-bound (over 99%) and is distributed throughout the body, including the central nervous system. It can cross the blood-brain barrier and effectively treat brain tumors. Â
MetabolismÂ
procarbazine is primarily metabolized in the liver and converted into an active metabolite called azoprocarbazine. Azoprocarbazine is metabolized into an alkylating agent called methyl diazohydroxide, which is responsible for the drug’s anticancer effects. Â
Elimination and ExcretionÂ
procarbazine has a relatively short half-life of approximately 10 hours and is eliminated primarily through the kidneys. The drug is excreted mainly in the urine, with a small amount in the feces.Â
Administration:Â
Oral administration:Â
Patient information leafletÂ
Generic Name: procarbazineÂ
Pronounced: [ pro-CAR-ba-zeen ]Â
Why do we use procarbazine?Â
procarbazine is primarily used in the treatment of certain types of cancer, including:Â
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