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Brand Name :
Chirostim
Synonyms :
secretin
Class :
Gastrointestinal agent, diagnostic agent
Brand Name :
Chirostim
Synonyms :
secretin
Class :
Gastrointestinal agent, diagnostic agent
Dosage Forms & Strengths
Powder for reconstitution, injection
16mcg/vial
40mcg/vial
Indicated for diagnosis of Pancreas dysfunction:
0.2mcg/kg intravenous infused for 1 minute
Indicated for diagnosis of Gastrinoma
0.4mcg/kg intravenous infused for 1 minute
Indicated for Identification of the Ampulla of Vater and Accessory Papilla During Endoscopic Retrograde Cholangiopancreatography
0.2mcg/kg intravenous infused for 1 minute
Safety and efficacy not established
Refer adult dosing
secretin: they may increase the CNS depressant effect of CNS Depressants
secretin: they may increase the CNS depressant effect of CNS Depressants
secretin: they may increase the CNS depressant effect of CNS Depressants
secretin: they may increase the CNS depressant effect of CNS Depressants
secretin: they may increase the CNS depressant effect of CNS Depressants
secretin: they may increase the CNS depressant effect of CNS Depressants
secretin: they may increase the CNS depressant effect of CNS Depressants
secretin: they may increase the CNS depressant effect of CNS Depressants
secretin: they may increase the bradycardic effect of Bradycardia-Causing Agents
secretin: they may increase the bradycardic effect of Bradycardia-Causing Agents
secretin: they may increase the bradycardic effect of Bradycardia-Causing Agents
secretin: they may increase the bradycardic effect of Bradycardia-Causing Agents
secretin: they may increase the bradycardic effect of Bradycardia-Causing Agents
may decrease the therapeutic effect of anticholinergic agents
may decrease the therapeutic effect of anticholinergic agents
may decrease the therapeutic effect of Anticholinergic Agents
may decrease the therapeutic effect of Anticholinergic Agents
may reduce the therapeutic effect of secretin
may reduce the therapeutic effect of secretin
may reduce the therapeutic effect of secretin
may reduce the therapeutic effect of secretin
may reduce the therapeutic effect of secretin
secretin: they may increase the hypertensive effect of sympathomimetics
secretin: they may increase the hypertensive effect of sympathomimetics
secretin: they may increase the hypertensive effect of sympathomimetics
secretin: they may increase the hypertensive effect of sympathomimetics
secretin: they may increase the hypertensive effect of sympathomimetics
anticholinergic agents decrease the efficacy of secretin
anticholinergic agents decrease the efficacy of secretin
anticholinergic agents decrease the efficacy of secretin
anticholinergic agents decrease the efficacy of secretin
anticholinergic agents decrease the efficacy of secretin
anticholinergic agents decrease the efficacy of secretin methacholine
anticholinergic agents decrease the efficacy of secretin methacholine
anticholinergic agents decrease the efficacy of secretin methacholine
anticholinergic agents decrease the efficacy of secretin methacholine
anticholinergic agents decrease the efficacy of secretin methacholine
Mechanism of action
It acts by binding to secretin receptors located on the pancreas and biliary tract cells. This binding leads to an increase in the intracellular level of cAMP, which in turn activates protein kinase A. The activation of protein kinase A leads to the stimulation of bicarbonate and water secretion.
Spectrum
It includes stimulating the pancreas to release bicarbonate, which neutralizes the acidity of chyme and creates the optimal environment for enzymatic digestion. Secretin also stimulates the liver to release bile and the gallbladder to contract, which helps to emulsify fats in the small intestine. Additionally, secretin helps to stimulate the pancreas to release enzymes that help to digest proteins, carbohydrates, and fats.
Frequency defined:
<1%
Vomiting
Upset stomach
Nausea
Flushing
Contraindications
None
Caution
Pregnancy consideration: Insufficient data available
Lactation: Excretion of the drug in human breast milk is unknown
Pregnancy category:
Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester.
Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.
Category D: adequate data available with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.
Category N: There is no data available for the drug under this category
Pharmacology
It is a hormone produced by S cells in the small intestine. Its primary function is to regulate the secretion of bicarbonate and water from the pancreas and the biliary tract in response to acidic chyme entering the small intestine. Upon exposure to gastric acid, fatty acids, and amino acids, secretin hormone is released from enterochromaffin cells in the intestinal mucosa. It stimulates the pancreas to secrete large volumes of fluid that contain bicarbonate. This bicarbonate neutralizes the acidity of chyme, creating the optimal environment for enzymatic digestion. Additionally, secretin also stimulates the liver to release bile and the gallbladder to contract, which helps to emulsify fats in the small intestine.
Pharmacodynamics
When administered, secretin binds to secretin receptors on the pancreas and biliary tract cells. This binding increases the intracellular level of cAMP, which activates protein kinase A. Activation of protein kinase A leads to the stimulation of bicarbonate and water secretion.
Bicarbonate secretion neutralizes the acidity of chyme, creating the optimal environment for enzymatic digestion. Additionally, secretin also stimulates the liver to release bile and the gallbladder to contract, which helps to emulsify fats in the small intestine.
In diagnostic procedures, a secretin stimulation test is used to evaluate the function of the pancreas, the biliary tract, and the intestinal mucosa by measuring the secretin-induced increase of the bicarbonate and water in the pancreatic juice.
Pharmacokinetics
Absorption
secretin is a hormone primarily produced by the S cells of the duodenum in response to acidic chyme entering the small intestine from the stomach.
Distribution
Its volume of distribution is relatively low, around 0.2 L/kg
Metabolism
It is rapidly metabolized in the liver and kidneys after it is released into the bloodstream
Elimination/excretion
It is eliminated from the body primarily through the kidneys via renal excretion.
Administration
Intravenous administration
The number of vials needed for a specific dose will depend on the desired dosage and the concentration of the reconstituted solution. The instructions indicate that a 16-mcg vial should be reconstituted with 8 mL of 0.9% NaCl to achieve a concentration of 2 mcg/mL, and a 40-mcg vial should be reconstituted with 10 mL of 0.9% NaCl to achieve a concentration of 4 mcg/mL. To determine the number of vials needed for a specific dose, you need to know the dosage and the concentration of the reconstituted solution.
Patient information leaflet
Generic Name: secretin
Pronounced: (se-KREE-tin)
Why do we use secretin?
It is a synthetic secretin hormone used in medical diagnostic procedures. It is typically administered as an intravenous injection and stimulates the secretion of digestive enzymes and bicarbonate from the pancreas and bile production from the liver. The resulting secretions can then be measured and analyzed to help diagnose conditions such as exocrine pancreas dysfunction, gastrinoma (a type of tumor that produces excessive amounts of the hormone gastrin), and abnormalities in the bile and pancreatic ducts. It can also be used to evaluate the function of the stomach and small intestine by assessing the secretions of these organs
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