Anthropometric Measurements as Predictors of Low Birth Weight Among Tanzanian Neonates: A Hospital-Based Study
November 7, 2025
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Brand Name :
Flomax
Synonyms :
tamsulosin
Class :
Alpha1 Blockers; BPH, Alpha Blockers
Brand Name :
Flomax
Synonyms :
tamsulosin
Class :
Alpha1 Blockers; BPH, Alpha Blockers
Dosage Forms & Strengths
Capsule
0.4mg
Indicated to treat the symptoms of BPH (benign prostatic hyperplasia)
0.4 mg orally each day; take the dose half an hour after the meals
After 2-4 weeks of inadequate response, increase the dose to 0.8 mg each day
If therapy is suspended for many days, start the dose at 0.4 mg each day and increase if required
(Off-Label)
It helps in expelling the kidney stones
0.4 mg orally each day, discontinue after the expulsion of stones
(Off-Label)
It helps in expelling the kidney stones
0.4 mg orally each day, discontinue after the expulsion of stones
Safety and efficacy are not seen in pediatrics
Refer to the adult dosing
It may enhance the levels when combined with tamsulosin by affecting CYP3A4 metabolism
It may diminish the levels when combined with tamsulosin by affecting CYP3A4 metabolism
It may enhance the levels when combined with tamsulosin by affecting CYP3A4 metabolism
It may enhance the levels when combined with tamsulosin by affecting CYP3A4 metabolism
It may diminish the levels when combined with tamsulosin by affecting CYP3A4 metabolism
tamsulosin: they may enhance the serum concentration of CYP2D6 Inhibitors
tamsulosin: they may enhance the serum concentration of CYP2D6 Inhibitors
tamsulosin: they may enhance the serum concentration of CYP2D6 Inhibitors
tamsulosin: they may enhance the serum concentration of CYP2D6 Inhibitors
tamsulosin: they may enhance the serum concentration of CYP2D6 Inhibitors
nafcillin will decrease the effect of action of tamsulosin by affecting enzyme CYP3A4 metabolism.
the effect of tamsulosin is decreased by lorlatinib, by altering intestinal or hepatic CYP3A4 enzyme metabolism
CYP3A4 inhibitors increase the concentration of tamsulosin in serum
CYP2D6 Inhibitors increase the concentration of tamsulosin in serum
It may enhance the levels when combined with tamsulosin by affecting CYP3A4 metabolism
It may diminish the levels when combined with tamsulosin by affecting CYP3A4 metabolism
It may enhance the levels when combined with tamsulosin by affecting CYP3A4 metabolism
It may enhance the levels when combined with tamsulosin by affecting CYP3A4 metabolism
It may enhance the levels when combined with tamsulosin by affecting CYP3A4 metabolism
It may enhance the levels when combined with tamsulosin by affecting CYP3A4 metabolism
It may enhance the levels when combined with tamsulosin by affecting CYP2D6 metabolism
It may enhance the levels when combined with tamsulosin by affecting CYP3A4 metabolism
It may diminish the levels when combined with tamsulosin by affecting CYP3A4 metabolism
It may enhance the levels when combined with tamsulosin by affecting CYP3A4 metabolism
It may enhance the levels when combined with tamsulosin by affecting CYP3A4 metabolism
It may enhance the levels when combined with tamsulosin by affecting CYP2D6 metabolism
It may diminish the levels when combined with tamsulosin by affecting CYP3A4 metabolism
It may diminish the levels when combined with tamsulosin by affecting CYP3A4 metabolism
It may enhance the levels when combined with tamsulosin by affecting CYP2D6 metabolism
It may enhance the levels when combined with tamsulosin by affecting CYP2D6 metabolism
It may enhance the levels when combined with tamsulosin by affecting CYP3A4 metabolism
It may enhance the levels when combined with tamsulosin by affecting CYP2D6 metabolism
It may enhance the levels when combined with tamsulosin by affecting CYP3A4 metabolism
It may enhance the levels when combined with tamsulosin by affecting CYP3A4 metabolism
It may diminish the levels when combined with tamsulosin by affecting CYP3A4 metabolism
It may enhance the levels when combined with tamsulosin by affecting CYP2D6 metabolism
Actions and Spectrum
Actions:
Spectrum:
The medication is not intended to treat the underlying cause of BPH but to alleviate its symptoms. It can be used to improve the quality of life for individuals experiencing bothersome urinary symptoms due to an enlarged prostate.
tamsulosin does not treat other causes of urinary symptoms, such as urinary tract infections or conditions affecting the bladder. It specifically targets the smooth muscle relaxation in the prostate and bladder neck.
Frequency defined
>10%:
Headache (19-21%)
Rhinitis (13-18%)
Abnormal ejaculation (8-18%)
Orthostatic hypotension (6-19%)
Dizziness (15-17%)
Infection (9-11%)
Arthralgia (11%)
1-10%:
Skin rash (7%)
Myalgia (5%)
Chest pain (4%)
Pharyngitis (5-6%)
Diarrhea (4-6%)
Cough (3-4%)
Sinusitis (2-4%)
Abdominal discomfort (2-3%)
Somnolence (3-4%)
Nausea (2-4%)
Bitter taste (2-3%)
Insomnia (1-2%)
Decreased libido (1-2%)
<1%:
Hyperesthesia
Infection (perianal)
Dyschromia
Infection (perianal)
Hyperesthesia
Infection (perianal)
Hyperesthesia
Eczema
Papule Local discoloration
Local dryness
Facial rash
Local tissue necrosis
Black Box Warning:
None
Contraindication/Caution:
Contraindications:
Cautions:
Pregnancy consideration:
No data is available regarding the use during pregnancy.
Breastfeeding warnings:
The excretion of the drug in breast milk is unknown.
Pregnancy category:
Category A: well-controlled and satisfactory studies show no risk to the fetus in the first or later trimester.
Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.
Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.
Category N: No data is available for the drug under this category.
Pharmacology:
tamsulosin is a medication used primarily for treating benign prostatic hyperplasia (BPH), a condition characterized by the enlargement of the prostate gland that can lead to urinary symptoms. It falls under the class of drugs known as alpha-1 adrenergic antagonists, also referred to as alpha-1 blockers. tamsulosin’s pharmacological actions are primarily related to its interaction with alpha-1 adrenergic receptors.
Pharmacodynamics:
Pharmacokinetics:
Absorption
tamsulosin is well-absorbed from the gastrointestinal tract, and food enhances absorption. However, food can also delay the onset of action.
Distribution
tamsulosin has a high affinity for alpha-1 adrenergic receptors. It has a relatively low degree of binding to plasma proteins, which may contribute to its ability to interact with target receptors readily.
Metabolism
tamsulosin undergoes hepatic metabolism, primarily through the cytochrome P450 enzyme system, particularly the CYP3A4 enzyme—metabolism results in the formation of inactive metabolites.
Elimination and Excretion
tamsulosin and its metabolites are primarily eliminated through renal excretion. Since the drug undergoes hepatic metabolism, liver function can affect its clearance.
Administration:
Patient information leaflet
Generic Name: tamsulosin
Pronounced as: tam-soo-LOE-sin
Why do we use tamsulosin?
tamsulosin treats benign prostatic hyperplasia (BPH). It relaxes the muscles of the bladder, neck, and prostate, making it easier to urinate. tamsulosin helps alleviate urinary difficulties associated with BPH, improving quality of life without requiring surgery.
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