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Brand Name :
Brethaire, Brethine
Synonyms :
terbutaline
Class :
Adrenergic bronchodilators, Tocolytic agents
Brand Name :
Brethaire, Brethine
Synonyms :
terbutaline
Class :
Adrenergic bronchodilators, Tocolytic agents
Dosage Forms & Strengths
tablet
2.5mg
5mg
injectable solution
1mg/mL
2.5-5 mcg/min IV initially;
Increase after 20–30-minute intervals; effective dose is between 17.5-30 mcg/min IV; In some cases, require doses up to 70-80 mcg/min
Continue 12 hr; should not exceed more than 48-72 hr
Orally use or prolonged IV use is not recommended.
Dose Adjustments
Renal Impairment
reduce dose by 50%, if GFR <50 mL/min
Dose adjustment is not necessary, if GFR >50mL/min
Orally:
2.5 mg 3-4 times daily orally
Maintenance: 5 mg thrice a day orally every 6hr; reduce dose to 2.5 mg every 6hr
Should not exceed more than 15 mg/Day
Sub cutaneous:
0.25 mg every 15-30min 3 divided doses when required in lateral deltoid; should not exceed 0.5mg/4hr
Dosage Forms & Strengths
tablet
2.5mg
5mg
injectable solution
1mg/mL
PO
Below 12 years: 0.05mg/kg thrice a day; increase when required, should not exceed more than 5mg/day
between 12-15years: 2.5mg orally every 6-hr trice a day; should not exceed more than 7.5 mg/day
Above 15 years: 5mg/dose orally every 8-hr trice a day; reduce the dose to 2.5mg every 6 hr; should not exceed more than 15mg/24hr
SC
Below 12 years: 0.005-0.01mg/kg every 15-20min trice a day; following every 2-6hrs when required.
Above 12 years: 0.25mg every 15-30min three divided doses when required in lateral deltoid; should not exceed 0.5mg/4hr
Refer to the adult dosing regimen
may increase the hypokalemic effect of thiazide diuretics
may increase the hypokalemic effect of thiazide diuretics
may increase the hypokalemic effect of thiazide diuretics
may increase the hypokalemic effect of thiazide diuretics
may increase the adverse effect of other beta2-agonists
may increase the adverse effect of other beta2-agonists
may increase the adverse effect of other beta2-agonists
may increase the adverse effect of other beta2-agonists
may increase the adverse effect of other beta2-agonists
may increase the toxic effect of beta2 agonists
may decrease the bronchodilatory effect
may decrease the bronchodilatory effect when combined with beta2-agonists
may decrease the bronchodilatory effect when combined with beta2-agonists
may decrease the bronchodilatory effect when combined with beta2-agonists
may decrease the bronchodilatory effect when combined with beta2-agonists
may decrease the bronchodilatory effect when combined with beta2-agonists
may decrease the bronchodilatory effect when combined with beta2-agonists
may decrease the bronchodilatory effect when combined with beta2-agonists
may increase the adverse effect of other beta2-agonists
may increase the adverse effect of other beta2-agonists
may increase the adverse effect of other beta2-agonists
may increase the adverse effect of other beta2-agonists
may increase the adverse effect of other beta2-agonists
may decrease the bronchodilatory effect of beta2-agonists
may decrease the bronchodilatory effect of beta2-agonists
may reduce the bronchodilatory effect
may reduce the bronchodilatory effect
may reduce the bronchodilatory effect
may reduce the bronchodilatory effect
may reduce the bronchodilatory effect
may reduce the bronchodilatory effect
may reduce the bronchodilatory effect
may increase the adverse effect of monoamine oxidase inhibitors
may increase the adverse effect of monoamine oxidase inhibitors
may increase the adverse effect of monoamine oxidase inhibitors
may increase the adverse effect of monoamine oxidase inhibitors
may increase the adverse effect of monoamine oxidase inhibitors
may have an increased hypokalemic effect when combined with loop diuretics
may have an increased hypokalemic effect when combined with loop diuretics
may have an increased hypokalemic effect when combined with loop diuretics
may increase the hypokalemic effect of thiazide diuretics
may increase the hypokalemic effect of thiazide diuretics
when used with terbutaline, butobarbital's therapeutic efficacy may be reduced
may decrease the bronchodilatory effect of beta-blockers
may decrease the bronchodilatory effect of beta-blockers
may decrease the bronchodilatory effect of beta-blockers
may decrease the bronchodilatory effect of beta-blockers
may increase the tachycardic effect of atomoxetine
may increase the hypokalemic effect of beta2-agonists
may increase the hypokalemic effect of beta2-agonists
may increase the hypokalemic effect of beta2-agonists
lisinopril/hydrochlorothiazideÂ
may increase the hypokalemic effect of blood pressure-lowering agents
may increase the risk or severity of hypertension when combined
may have an increasingly adverse effect when combined with beta2-agonists
may have an increasingly adverse effect when combined with beta2-agonists
may have an increasingly adverse effect when combined with beta2-agonists
may have an increasingly adverse effect when combined with beta2-agonists
may have an increasingly adverse effect when combined with beta2-agonists
may have an increasingly adverse effect when combined with beta2-agonists
may have an increasingly adverse effect when combined with beta2-agonists
Actions and spectrum:
terbutaline is a medication that belongs to the class of beta-2 adrenergic receptor agonists. It is primarily used as a bronchodilator to treat and prevent symptoms of asthma and chronic obstructive pulmonary disease (COPD). It works by relaxing the smooth muscles in the airways, which allows the air to flow more easily in and out of the lungs.
In addition to its bronchodilator effect, terbutaline can also stimulate the heart and increase blood pressure, and as a result, it is used to treat certain conditions such as arrhythmias and heart failure. Terbutaline may also be used off-label for the treatment of preterm labor by relaxing the uterus and delaying delivery.
Frequency undefined:
Nervousness
Transient hyperglycemia
Trembling
HTN
Dizziness
Drowsiness
Insomnia
Nausea
Bad taste in mouth
Weakness
Cardiac arrhythmias
Myocardial ischemia
Increased fetal heart rate
Restlessness
Transient hypokalemia
Tachycardia
Pounding heartbeat
Lightheadedness
Headache
Dry mouth
Vomiting
Muscle cramps
Diaphoresis
Pulmonary edema
Myocardial infarction
Hypoglycemia
Black Box Warning
The risk of significant adverse effects outweighs the possible benefit for pregnant women undergoing prolonged terbutaline injection (i.e., >48-72 hr) or acute or chronic oral terbutaline medication.
Death and major adverse reactions have been reported after pregnant women were given oral or injectable terbutaline for an extended period.
Contraindication/Caution
Contraindication
Caution
Comorbidities
Pregnancy consideration: Pregnancy Category: C
Lactation: not recommended in lactation as it passes into breast milkÂ
Pregnancy category:
Pharmacology
terbutaline is a beta-2 adrenergic agonist that stimulates beta-2 adrenergic receptors in the lungs and uterus. It is a bronchodilator that relaxes the smooth muscle in the airways and allows for increased airflow. In addition, it can also relax the smooth muscle of the uterus and inhibit contractions, making it useful for delaying premature labor.
terbutaline is a selective beta-2 adrenergic agonist, which means it primarily targets beta-2 receptors and has little effect on beta-1 receptors. This selectivity results in fewer cardiovascular side effects than non-selective beta-agonists.
Pharmacodynamics
terbutaline is a beta-2 adrenergic receptor agonist. It works by stimulating beta-2 adrenergic receptors in the smooth muscles of the bronchi, uterus, and blood vessels. This results in the relaxation of these muscles, leading to bronchodilation, uterine relaxation, and vasodilation.
terbutaline also increases the production of cyclic AMP (cAMP) by stimulating the adenylate cyclase enzyme. Increased cAMP levels lead to the activation of protein kinase A (PKA), which then mediates the relaxation of the smooth muscles.
pharmacokinetics
terbutaline is rapidly absorbed after oral or subcutaneous administration, with peak plasma concentrations reached within 30 to 60 minutes. The onset of action occurs within 5 to 15 minutes after subcutaneous administration and within 30 minutes after oral administration. The drug gets metabolized by the liver and excreted in the urine, with a half-life of 4 to 6 hours in adults. The pharmacokinetics of terbutaline may be altered in patients with hepatic impairment, renal impairment, or congestive heart failure.
Administration
terbutaline can be administered in various forms, including oral tablets, subcutaneous injections, and inhalation via metered-dose inhalers or nebulizers. The specific route of administration and dosing regimen may vary depending on the condition being treated, the patient’s age, and other factors.
Patient information leaflet
Generic Name: terbutaline
Pronounced: (ter-bue-ta-leen-)
Why do we use terbutaline?
terbutaline is a medication primarily used to treat bronchospasm in conditions such as asthma, chronic obstructive pulmonary disease (COPD), and bronchitis. It is a beta-2 agonist, which means it acts by relaxing smooth muscles in the airway, allowing for easier breathing.
In addition to its use in respiratory conditions, terbutaline is also used to delay premature labor by relaxing the uterine smooth muscle. It can also be used to treat high blood pressure and other conditions where the relaxation of smooth muscle is beneficial.
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