Long COVID Patterns in the RECOVER-Adult Study
November 21, 2025
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Brand Name :
N/AÂ
Synonyms :
vilanterol
Class :
Adrenergic Agonists
Brand Name :
N/AÂ
Synonyms :
vilanterol
Class :
Adrenergic Agonists
Dosage forms and strengths Â
Inhaler powderÂ
62.5 mcgÂ
off-label:
Take 62.5 mcg two times a day
Note: A daily regimen of vilanterol therapy were best tolerated & enhancements in pulmonary function was observed
Not indicatedÂ
Refer adult dosingÂ
may increase the hypokalemic effect of thiazide diuretics
may increase the hypokalemic effect of thiazide diuretics
may increase the hypokalemic effect of thiazide diuretics
may increase the hypokalemic effect of thiazide diuretics
may increase the adverse effect of other beta2-agonists
may increase the adverse effect of other beta2-agonists
may increase the adverse effect of other beta2-agonists
may increase the adverse effect of other beta2-agonists
may increase the adverse effect of other beta2-agonists
May diminish the effects of carvedilol by pharmacodynamic antagonism
may increase the toxic effect of beta2 agonists
may decrease the bronchodilatory effect
may decrease the bronchodilatory effect when combined with beta2-agonists
may decrease the bronchodilatory effect when combined with beta2-agonists
may decrease the bronchodilatory effect when combined with beta2-agonists
may decrease the bronchodilatory effect when combined with beta2-agonists
may decrease the bronchodilatory effect when combined with beta2-agonists
may decrease the bronchodilatory effect when combined with beta2-agonists
may decrease the bronchodilatory effect when combined with beta2-agonists
may increase the adverse effect of other beta2-agonists
may increase the adverse effect of other beta2-agonists
may increase the adverse effect of other beta2-agonists
may increase the adverse effect of other beta2-agonists
may increase the adverse effect of other beta2-agonists
may decrease the bronchodilatory effect of beta2-agonists
may decrease the bronchodilatory effect of beta2-agonists
may reduce the bronchodilatory effect
may reduce the bronchodilatory effect
may reduce the bronchodilatory effect
may reduce the bronchodilatory effect
may reduce the bronchodilatory effect
may reduce the bronchodilatory effect
may reduce the bronchodilatory effect
may increase the adverse effect of monoamine oxidase inhibitors
may increase the adverse effect of monoamine oxidase inhibitors
may increase the adverse effect of monoamine oxidase inhibitors
may increase the adverse effect of monoamine oxidase inhibitors
may increase the adverse effect of monoamine oxidase inhibitors
may have an increased hypokalemic effect when combined with loop diuretics
may have an increased hypokalemic effect when combined with loop diuretics
may have an increased hypokalemic effect when combined with loop diuretics
may increase the hypokalemic effect of thiazide diuretics
may increase the hypokalemic effect of thiazide diuretics
vilanterol may decrease the excretion rate of n-acetyl tyrosine, potentially resulting in elevated serum levels
vilanterol may decrease the excretion rate of sulbactam, potentially resulting in a higher serum level
combining vilanterol with carbaspirin calcium may increase the chances of hypertension
the risk or extent of adverse effects can be raised when doxofylline is combined with vilanterol
may decrease the bronchodilatory effect of beta-blockers
may decrease the bronchodilatory effect of beta-blockers
may decrease the bronchodilatory effect of beta-blockers
may decrease the bronchodilatory effect of beta-blockers
may increase the tachycardic effect of atomoxetine
may increase the hypokalemic effect of beta2-agonists
may increase the hypokalemic effect of beta2-agonists
may increase the hypokalemic effect of beta2-agonists
lisinopril/hydrochlorothiazideÂ
may increase the hypokalemic effect of blood pressure-lowering agents
may have an increasingly adverse effect when combined with beta2-agonists
may have an increasingly adverse effect when combined with beta2-agonists
may have an increasingly adverse effect when combined with beta2-agonists
may have an increasingly adverse effect when combined with beta2-agonists
may have an increasingly adverse effect when combined with beta2-agonists
may have an increasingly adverse effect when combined with beta2-agonists
may have an increasingly adverse effect when combined with beta2-agonists
When aceclofenac is used together with vilanterol, this leads to enhanced risk or seriousness of hypertension
When acetylsalicylic acid is used together with vilanterol, this leads to enhanced risk or seriousness of hypertension
When alclofenac is used together with vilanterol, this leads to enhanced risk or seriousness of hypertension
When alfentanil is used together with vilanterol, this leads to enhanced risk or seriousness of hypertension
the risk of adverse effects may be increased
Actions and Spectrum:Â
Action:Â
Bronchodilation: vilanterol relaxes the smooth muscles in the bronchial airways. This activity results in the expansion of the respiratory passages, facilitating improved breathing for individuals. This bronchodilation helps relieve symptoms such as shortness of breath and wheezing in conditions like asthma and COPD.Â
Spectrum:Â
Asthhma: vilanterol is used in combination with an inhaled corticosteroid (ICS) as a maintenance treatment for asthma in individuals whose symptoms are not adequately controlled by ICS alone. It is usually administered in combination inhalers with ICS to improve asthma control and reduce the risk of exacerbations.Â
Frequency not defined Â
Abnormal heart rhythmsÂ
Hoarse voiceÂ
Runny or stuffy noseÂ
Increased blood pressureÂ
FeverÂ
Joint painÂ
Back painÂ
HeadacheÂ
Black Box Warning:Â Â
None
Contraindication/Caution:Â Â
Hypersensitivity: vilanterol should not be used in individuals with a known hypersensitivity or allergic reaction to the drug or its components.Â
Cardiovascular Conditions: Caution is advised in patients with pre-existing cardiovascular conditions, especially those with a history of arrhythmias, ischemic heart disease, and hypertension, as LABAs may exacerbate these conditions. Â
Pregnancy and Lactation: The safety of vilanterol during pregnancy and breastfeeding is not well established. One must carefully consider the possible advantages considering the associated hazards, and it is advisable to seek guidance from medical professionals.Â
Pediatric Use: vilanterol is not generally indicated for use in children under a certain age, and the specific age varies depending on the condition it is being used to treat. Consult a healthcare provider for appropriate age-related guidelines.Â
Pregnancy warnings:    Â
Pregnancy category: N/AÂ
Lactation: Excreted into human milk is unknownÂ
Pregnancy Categories:        Â
Category A: Studies that were well-controlled and met expectations revealed no risk to the fetus in either the first or second trimester.Â
Category B: There were a lack of studies on pregnant women and no evidence of risk to the fetus in animal experiments.  Â
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.   Â
Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.  Â
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.   Â
Category N: There is no data available for the drug under this category
Pharmacology: vilanterol is a long-acting beta2-adrenergic agonist used in COPD and asthma.Â
Pharmacodynamics:Â Â
Bronchodilation: Activation of beta2 receptors in airway smooth muscle leads to relaxation of the bronchial muscles, resulting in bronchodilation and increased airflow to the lungs. This helps relieve symptoms in patients with COPD and asthma.Â
Inhibition of Inflammatory Mediators: While LABAs like vilanterol are primarily bronchodilators, they may also have some anti-inflammatory effects by reducing the release of inflammatory mediators from immune cells. Â
Pharmacokinetics:Â
AbsorptionÂ
Following inhalation, vilanterol is rapidly absorbed into the systemic circulation.Â
DistributionÂ
The drug is distributed throughout the body, with a significant portion binding to plasma proteins.Â
MetabolismÂ
vilanterol is primarily metabolized by the liver, primarily through the cytochrome P450 (CYP) 3A4 enzyme. The major metabolite, vilanterol phenolic, is pharmacologically inactive.Â
Excretion and EliminationÂ
Metabolites of vilanterol are eliminated primarily in the feces, with a smaller portion excreted in the urine.Â
Administration: Â
The dosage of vilanterol can vary from person to person. It is typically administered as an inhaled powder through a dry powder inhaler (DPI) device. The recommended dosage will depend on the product’s instructions and your healthcare provider’s recommendations. The typical dose is usually once daily.Â
Patient information leafletÂ
Generic Name: vilanterolÂ
Why do we use vilanterol? Â
vilanterol is often used in combination with an inhaled corticosteroid (ICS) to provide long-term maintenance treatment for patients with COPD. vilanterol is employed in combination with an inhaled corticosteroid (ICS) for the sustained management of asthma in patients who necessitate the use of a prolonged-acting bronchodilator alongside their ICS. It can help improve asthma control and reduce the frequency of asthma exacerbations.Â
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