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November 22, 2025
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Brand Name :
Augmentin ES-600, Augmentin, Augmentin XR
Synonyms :
Class :
Beta-lactamase inhibitors
Brand Name :
Augmentin ES-600, Augmentin, Augmentin XR
Synonyms :
Class :
Beta-lactamase inhibitors
Dosage Forms & Strengths
oral suspension
125mg/31.25mg- amoxicillin/clavulanate per 5ml
200mg/28.5mg- amoxicillin/clavulanate per 5ml
250mg/62.5mg-amoxicillin/clavulanate per 5ml
400mg/57mg- amoxicillin/clavulanate per 5ml
600mg/42.9mg- amoxicillin/clavulanate per 5ml
tablet
250mg/125mg – amoxicillin/clavulanate
500mg/125mg – amoxicillin/clavulanate
875mg/125mg – amoxicillin/clavulanate
Tablet-ER
1000mg/62.5mg – amoxicillin/clavulanate
tablet, chewable – amoxicillin/clavulanate
200mg/28.5mg – amoxicillin/clavulanate
400mg/57mg – amoxicillin/clavulanate
Indicated for Aspirational pneumonia
:
500 mg orally 3 times a day or 875 mg orally 2 times a day
Depending on the type and severity of the infection, therapy should be continued until the infiltrate is removed or a residual scar forms, which could take up to four months
500 mg orally 3 times a day or 875 mg orally 2 times daily 7-10 days
250 mg orally 3 times daily or 500 mg orally 2 times a day 10-14 days
Dosage Forms & Strengths
oral suspension
125mg,31.25mg- amoxicillin, clavulanate per 5ml
200mg,28.5mg- amoxicillin, clavulanate per 5ml
250mg,62.5mg-amoxicillin, clavulanate per 5ml
400mg,57mg- amoxicillin, clavulanate per 5ml
600mg,42.9mg- amoxicillin, clavulanate per 5ml
tablet
250mg,125mg – amoxicillin, clavulanate
500mg,125mg – amoxicillin, clavulanate
875mg,125mg – amoxicillin, clavulanate
Tablet-ER
1000mg,62.5mg – amoxicillin, clavulanate
tablet, chewable – amoxicillin, clavulanate
200mg,28.5mg – amoxicillin, clavulanate
400mg,57mg – amoxicillin, clavulanate
Weight: <40 kg
Dosages based on amoxicillin
Age: <3 months old
30 mg/kg orally divided every 12 hours
Age: >3 months old
Mild-moderate: 20 mg/kg orally divided every 8 hours a day
Severe: 40 mg/kg orally divided every 8 hours a day
Age: < 3 months
For infants under 12 weeks:
Administer 15 mg per kilogram orally 2 times daily with 125 mg/5 mL oral suspension
Age: >3 months
For children weighing less than 40 kg:
With 125 mg/5 mL or 250 mg/5 mL oral suspension, administer orally 3 times daily at a dosage range of 6.67 to 13.33 mg per kilogram
With 200 mg/5 mL or 400 mg/5 mL oral suspension or chewable tablets, administer orally 2 times daily at a dosage range of 12.5 to 22.5 mg per kilogram
For children weighing 40 kg or more:
Immediate release tablets: Administer 500 mg orally every 8 hours or 875 mg orally 2 times daily
Extended release tablets: 2 g orally 2 times daily for 7 to 10 days in cases of community-acquired pneumonia
measles, mumps, rubella, and varicella vaccine, live (Rx)
may diminish the therapeutic effect
measles mumps and rubella vaccine, live
may diminish the therapeutic effect
may diminish the therapeutic effect
smallpox (vaccinia) vaccine, live
may diminish the therapeutic effect
may diminish the therapeutic effect
sodium picosulfate citric acid and magnesium oxide
it may reduce the therapeutic effect of sodium picosulfate
antibiotics may diminish the therapeutic effect of Bacillus clausii
antibiotics may diminish the therapeutic effect of Typhoid Vaccine
antibiotics may diminish the therapeutic effect of typhoid Vaccine
meningococcal A C Y and W-135 diphtheria conjugate vaccine
may enhance the serum concentration of Betalactamase Inhibitors
may enhance the serum concentration of Betalactamase Inhibitors
may enhance the serum concentration of Betalactamase Inhibitors
may enhance the serum concentration of Betalactamase Inhibitors
may enhance the serum concentration of Betalactamase Inhibitors
when amoxicillin combines with bcg vaccine it decreases the effects of action of vaccine by antagonism effect
when amoxicillin combines with cholera vaccine it decreases the effects of action of vaccine by antagonism effect
when amoxicillin combines with demeclocycline it decreases the effects of action of drug by antagonism effect
when amoxicillin combines with doxycycline it decreases the effects of action of drug by antagonism effect
when amoxicillin combines with eravacycline it decreases the effects of action of drug by antagonism effect
when amoxicillin combines with minocycline it decreases the effects of action of drug by antagonism effect
when amoxicillin combines with mycophenolate it decreases the effects of action of drug and it may result impairment of enterohepatic recirculation
when amoxicillin combines with omadacycline it decreases the effects of action of drug by antagonism effect
when amoxicillin combines with pexidartinib it decreases the effects of action of drug and results in hepatotoxicity
when amoxicillin combines with pretomanid it decreases the effects of action of drug and results in hepatotoxicity
when amoxicillin combines with sarecycline it decreases the effects of action of drug by antagonism effect
when amoxicillin combines with tetracycline it decreases the effects of the action of drug by antagonism effect
when amoxicillin combines with typhoid vaccine it decreases the effects of action of vaccine by antagonism effect
it may diminish the therapeutic effect of cholera Vaccine
antibiotics decrease the efficacy of intravesical BCG
antibiotics decrease the efficacy of cholera vaccine
when amoxicillin combines with acyclovir it decreases the effects of the action of drug by decreasing renal clearance
when amoxicillin combines with allopurinol it decreases the effects of the drug by resulting hypersensitivity reaction
when amoxicillin combines with anisindione it decreases the effects of action of the drug and results in renal and liver impairment
when amoxicillin combines with aspirin it decreases the effects of action of drug by plasma binding protein and results in lowering of renal clearance
when amoxicillin combines with aspirin rectal it decreases the effects of action of drug by plasma binding protein and results in lowering of renal clearance
when amoxicillin combines with aspirin citric acid it decreases the effects of the action of drug and results in lowering of renal clearance
when amoxicillin combines with bazedoxifene it decreases the effects of action of drug and results in changes of intestinal flora
when amoxicillin combines with bendroflumethiazide it decreases the effects of the action of drug by decreasing renal clearance
when amoxicillin combines with chlorothiazide it decreases the effects of the action of drug by decreasing renal clearance
choline magnesium tri salicylate
when amoxicillin combines with choline magnesium tri salicylate it decreases the effects of action of drug by plasma binding protein and results in lowering of renal clearance
when amoxicillin combines with cyclopenthiazide it decreases the effects of the action of drug by decreasing renal clearance
when amoxicillin combines with dienogest it decreases the effects of action of drug and results in changes of intestinal flora
when amoxicillin combines with estradiol it decreases the effects of the action of drug and results in changes of intestinal flora
when amoxicillin combines with ethinylestradiol it decreases the effects of action of the drug and results in changes of intestinal flora
when amoxicillin combines with hydrochlorothiazide it decreases the effects of the action of drug by decreasing renal clearance
when amoxicillin combines with levonorgestrel oral it decreases the effects of action of the drug and results in changes of intestinal flora
when amoxicillin combines with mestranol it decreases the effects of action of the drug
when amoxicillin combines with methotrexate it decreases the effects of the action of drug by decreasing renal clearance
when amoxicillin combines with methyclothiazide it decreases the effects of the action of drug by decreasing renal clearance
when amoxicillin combines with metolazone it decreases the effects of the action of drug by decreasing renal clearance
when amoxicillin combines with rose hips it decreases the effects of the action of drug by decreasing renal clearance
when amoxicillin combines with salicylates it decreases the effects of action of drug by plasma binding protein and results in lowering of renal clearance
when amoxicillin combines with salsalate it decreases the effects of action of drug by plasma binding protein and results in lowering of renal clearance
when amoxicillin combines with sodium phenylacetate it decreases the effects of the action of drug by decreasing renal clearance
when amoxicillin combines with metolazone it decreases the effects of the action of drug and results in changing metabolism
when amoxicillin combines with sulfasalazine it decreases the effects of action of drug by plasma binding protein and results in lowering of renal clearance
when amoxicillin combines with willow bark it decreases the effects of the action of drug by decreasing renal clearance
when amoxicillin combines with warfarin it decreases the effects of the action of drug by increasing bleeding and results in renal and liver impairment
Enhance the neuromuscular effect of NMBAs
Enhance the neuromuscular effect of NMBAs
Enhance the neuromuscular effect of NMBAs
Enhance the neuromuscular effect of NMBAs
Enhance the neuromuscular effect of NMBAs
antibiotics may reduce the therapeutic effect of immune checkpoint inhibitors
antibiotics may reduce the therapeutic effect of immune checkpoint inhibitors
antibiotics may reduce the therapeutic effect of immune checkpoint inhibitors
may diminish the therapeutic effect
may diminish the therapeutic effect
may diminish the therapeutic effect
may increase the anticoagulant effect
may increase the anticoagulant effect
may increase the anticoagulant effect
may increase the anticoagulant effect
may increase the anticoagulant effect
Penicillins: they may diminish the serum concentration of aminoglycosides
neomycin/polymyxin B/bacitracin topical
Penicillins: they may diminish the serum concentration of aminoglycosides
Penicillins: they may diminish the serum concentration of aminoglycosides
Penicillins: they may diminish the serum concentration of aminoglycosides
Penicillins: they may diminish the serum concentration of aminoglycosides
antibiotics may reduce the therapeutic effect of bcg Vaccine
antibiotics decrease the efficacy of lactobacillus
may diminish the therapeutic effect of immune checkpoint inhibitors
may diminish the therapeutic effect of immune checkpoint inhibitors
may diminish the therapeutic effect of immune checkpoint inhibitors
may decrease the therapeutic effect of antibiotics
bismuth subcitrate, metronidazole and tetracycline
may reduce the therapeutic effect of penicillins
may reduce the therapeutic effect of penicillins
may reduce the therapeutic effect of penicillins
may reduce the therapeutic effect of penicillins
may reduce the therapeutic effect of penicillins
acemetacin: they may enhance the serum concentration of penicillins
dichlorphenamide: they may increase the hypokalemic effect of penicillins
may reduce the therapeutic effect of typhoid Vaccine
Could potentially reduce concentration serum for the active metabolite(s) of mycophenolate
It may enhance the risk of adverse effects when combined with polypeptide antibiotic
may decrease the therapeutic effect when combined with penicillins
when amoxicillin combines with amiloride it decreases the effects of the action of drug by increasing gi absorption
when amoxicillin combines with azithromycin it decreases the effects of action of drug by antagonism effect
when amoxicillin combines with aztreonam it decreases the effects of action of drug by synergestic effect
when amoxicillin combines with chloramphenicol it decreases the effects of the action of drug by antagonism effect
when amoxicillin combines with clarithromycin it decreases the effects of action of drug by antagonism effect
when amoxicillin combines with erythromycin base it decreases the effects of action of drug by antagonism effect
when amoxicillin combines with erythromycin ethylsuccinate it decreases the effects of action of drug by antagonism effect
when amoxicillin combines with erythromycin lactobionate it decreases the effects of action of drug by antagonism effect
when amoxicillin combines with erythromycin stearate it decreases the effects of action of drug by antagonism effect
when amoxicillin combines with pyridoxine it decreases the effects of action of the drug and results in changes of intestinal flora
when amoxicillin combines with troleandomycin it decreases the effects of action of drug by antagonism effect
antibiotics decrease the efficacy of Bacillus clausii
antibiotics decrease the efficacy of typhoid vaccine
probenecid has the potential to elevate the concentration serum of Beta-lactamase Inhibitors
Adverse drug reactions:
Frequency Defined
1-10%
Mycosis (3.3%)
Nausea (2-3%)
Rash (1-3%)
Candidiasis (1.4%)
Vaginitis (1%)
Diaper rash (3.5%)
Vomiting (1-2.2%)
Loose stool (1.6%)
<1%
Leukopenia
Agranulocytosis
Hepatoxicity
Serum sickness
Abdominal discomfort
Cholestatic jaundice
AST/ALT elevation
Pseudomembranous colitis
Hypersensitivity reactions
Anaphylaxis
Anemia
Thrombocytopenia
Pregnancy warnings:
Pregnancy category: N/A
Breastfeeding warnings:
crosses into breast milk- known
Pregnancy Categories:
Patient Information Leaflet
Generic Name: amoxicillin and clavulanate potassium
Why do we use amoxicillin and clavulanate potassium?
amoxicillin and clavulanate potassium belong to the class Beta-lactamase inhibitors used to treat many bacterial infections such as, pneumonia, otitis media, bronchitis, UTI, and skin infections.
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