Microplastics and Misinformation: What Science Really Says
November 12, 2025
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Brand Name :
N/A
Synonyms :
andrographolide
Class :
Anti-infective agent
Brand Name :
N/A
Synonyms :
andrographolide
Class :
Anti-infective agent
Dosage forms and strengths Â
Oral tablet Â
140 mg Â
In vivo, data suggests the suggested dose is to take andrographolide 140 mg two times orally daily
The treatment duration is two years
In vivo, data suggests the suggested dose is to take andrographolide 140 mg two times orally daily
The treatment duration is two years
In vivo, data suggests the suggested dose is to take andrographolide 140 mg two times orally daily The treatment duration is two years
Not indicatedÂ
Refer adult dosingÂ
When andrographolide is used together with abciximab, this leads to enhanced risk or seriousness of bleeding
When andrographolide is used together with aceclofenac, this leads to enhanced risk or seriousness of bleeding
When andrographolide is used together with acemetacin, this leads to enhanced risk or seriousness of bleeding
When andrographolide is used together with acenocoumarol, this leads to enhanced risk or seriousness of bleeding
When andrographolide is used together with alclofenac, this leads to enhanced risk or seriousness of bleeding
When andrographolide is used together with aldesleukin, this leads to enhanced risk or seriousness of bleeding
When andrographolide is used together with alemtuzumab, this leads to enhanced risk or seriousness of bleeding
When altretamine is used together with andrographolide, this leads to enhanced risk or seriousness of bleeding
When aminophenazone is used together with andrographolide, this leads to enhanced risk or seriousness of bleeding
When aminosalicylic acid is used together with andrographolide, this leads to enhanced risk or seriousness of bleeding
When amsacrine is used together with andrographolide, this leads to enhanced risk or seriousness of bleeding
When antipyrine is used together with andrographolide, this leads to enhanced risk or seriousness of bleeding
When antrafenine is used together with andrographolide, this leads to enhanced risk or seriousness of bleeding
When argatroban is used together with andrographolide, this leads to enhanced risk or seriousness of bleeding
When arsenic trioxide is used together with andrographolide, this leads to enhanced risk or seriousness of bleeding
When azacitidine is used together with andrographolide, this leads to enhanced risk or seriousness of bleeding
When balsalazide is used together with andrographolide, this leads to enhanced risk or seriousness of bleeding
When belinostat is used together with andrographolide, this leads to enhanced risk or seriousness of bleeding
When bendamustine is used together with andrographolide, this leads to enhanced risk or seriousness of bleeding
When benorilate is used together with andrographolide, this leads to enhanced risk or seriousness of bleeding
When benoxaprofen is used together with andrographolide, this leads to enhanced risk or seriousness of bleeding
When benzydamine is used together with andrographolide, this leads to enhanced risk or seriousness of bleeding
When betrixaban is used together with andrographolide, this leads to enhanced risk or seriousness of bleeding
When bexarotene is used together with andrographolide, this leads to enhanced risk or seriousness of bleeding
When bivalirudin is used together with andrographolide, this leads to enhanced risk or seriousness of bleeding
When blinatumomab is used together with andrographolide, this leads to enhanced risk or seriousness of bleeding
When bortezomib is used together with andrographolide, this leads to enhanced risk or seriousness of bleeding
When bosutinib is used together with andrographolide, this leads to enhanced risk or seriousness of bleeding
When bumadizone is used together with andrographolide, this leads to enhanced risk or seriousness of bleeding
When busulfan is used together with andrographolide, this leads to enhanced risk or seriousness of bleeding
When cabazitaxel is used together with andrographolide, this leads to enhanced risk or seriousness of bleeding
When capecitabine is used together with andrographolide, this leads to enhanced risk or seriousness of bleeding
When carbamazepine is used together with andrographolide, this leads to enhanced risk or seriousness of bleeding
When carboplatin is used together with andrographolide, this leads to enhanced risk or seriousness of bleeding
When carfilzomib is used together with andrographolide, this leads to enhanced risk or seriousness of bleeding
When carmustine is used together with andrographolide, this leads to enhanced risk or seriousness of bleeding
When carprofen is used together with andrographolide, this leads to enhanced risk or seriousness of bleeding
When celecoxib is used together with andrographolide, this leads to enhanced risk or seriousness of bleeding
When chlorambucil is used together with andrographolide, this leads to enhanced risk or seriousness of bleeding
When chloramphenicol is used together with andrographolide, this leads to enhanced risk or seriousness of bleeding
When choline salicylate is used together with andrographolide, this leads to enhanced risk or seriousness of bleeding
When cisplatin is used together with andrographolide, this leads to enhanced risk or seriousness of bleeding
When citalopram is used together with andrographolide, this leads to enhanced risk or seriousness of bleeding
When cladribine is used together with andrographolide, this leads to enhanced risk or seriousness of bleeding
When clofarabine is used together with andrographolide, this leads to enhanced risk or seriousness of bleeding
When cyclophosphamide is used together with andrographolide, this leads to enhanced risk or seriousness of bleeding
When cytarabine is used together with andrographolide, this leads to enhanced risk or seriousness of bleeding
When dabigatran is used together with andrographolide, this leads to enhanced risk or seriousness of bleeding
When dacarbazine is used together with andrographolide, this leads to enhanced risk or seriousness of bleeding
When dactinomycin is used together with andrographolide, this leads to enhanced risk or seriousness of bleeding
When dalteparin is used together with andrographolide, this leads to enhanced risk or seriousness of bleeding
When danaparoid is used together with andrographolide, this leads to enhanced risk or seriousness of bleeding
When daunorubicin is used together with andrographolide, this leads to enhanced risk or seriousness of bleeding
When decitabine is used together with andrographolide, this leads to enhanced risk or seriousness of bleeding
When defibrotide is used together with andrographolide, this leads to enhanced risk or seriousness of bleeding
When desirudin is used together with andrographolide, this leads to enhanced risk or seriousness of bleeding
When desvenlafaxine is used together with andrographolide, this leads to enhanced risk or seriousness of bleeding
When dexibuprofen is used together with andrographolide, this leads to enhanced risk or seriousness of bleeding
When dexketoprofen is used together with andrographolide, this leads to enhanced risk or seriousness of bleeding
When dexrazoxane is used together with andrographolide, this leads to enhanced risk or seriousness of bleeding
When dextran is used together with andrographolide, this leads to enhanced risk or seriousness of bleeding
When diclofenac is used together with andrographolide, this leads to enhanced risk or seriousness of bleeding
When dicoumarol is used together with andrographolide, this leads to enhanced risk or seriousness of bleeding
When diflunisal is used together with andrographolide, this leads to enhanced risk or seriousness of bleeding
When dinutuximab is used together with andrographolide, this leads to enhanced risk or seriousness of bleeding
When dipyridamole is used together with andrographolide, this leads to enhanced risk or seriousness of bleeding
When docetaxel is used together with andrographolide, this leads to enhanced risk or seriousness of bleeding
When doxorubicin is used together with andrographolide, this leads to enhanced risk or seriousness of bleeding
When edoxaban is used together with andrographolide, this leads to enhanced risk or seriousness of bleeding
When enoxaparin is used together with andrographolide, this leads to enhanced risk or seriousness of bleeding
When epirubicin is used together with andrographolide, this leads to enhanced risk or seriousness of bleeding
When epoprostenol is used together with andrographolide, this leads to enhanced risk or seriousness of bleeding
When eribulin is used together with andrographolide, this leads to enhanced risk or seriousness of bleeding
When escitalopram is used together with andrographolide, this leads to enhanced risk or seriousness of bleeding
When etodolac is used together with andrographolide, this leads to enhanced risk or seriousness of bleeding
When etoposide is used together with andrographolide, this leads to enhanced risk or seriousness of bleeding
When etoricoxib is used together with andrographolide, this leads to enhanced risk or seriousness of bleeding
When everolimus is used together with andrographolide, this leads to enhanced risk or seriousness of bleeding
When fenbufen is used together with andrographolide, this leads to enhanced risk or seriousness of bleeding
When fenoprofen is used together with andrographolide, this leads to enhanced risk or seriousness of bleeding
When floctafenine is used together with andrographolide, this leads to enhanced risk or seriousness of bleeding
When floxuridine is used together with andrographolide, this leads to enhanced risk or seriousness of bleeding
When flucytosine is used together with andrographolide, this leads to enhanced risk or seriousness of bleeding
When fludarabine is used together with andrographolide, this leads to enhanced risk or seriousness of bleeding
When fluindione is used together with andrographolide, this leads to enhanced risk or seriousness of bleeding
When fluorouracil is used together with andrographolide, this leads to enhanced risk or seriousness of bleeding
Actions and Spectrum:Â
Anti-Inflammatory:Â
andrographolide demonstrates potent anti-inflammatory characteristics by suppressing the synthesis of pro-inflammatory cytokines and mediators making it useful in the treatment of various inflammatory conditions.Â
Antioxidant:Â
andrographolide possesses antioxidant properties, helping to neutralize harmful free radicals in the body. This can be beneficial in reducing oxidative stress and preventing cellular damage.Â
Frequency not defined Â
FatigueÂ
Runny noseÂ
HeadacheÂ
RashÂ
VomitingÂ
DiarrheaÂ
Loss of appetiteÂ
Black Box Warning:Â Â
None
Contraindication/Caution:Â Â
Allergies: Individuals with a known allergy or hypersensitivity to andrographolide or any related compounds in the andrographis plant should avoid its use.Â
Pregnancy and breast-feeding: Insufficient research has been conducted to adequately assess the safety of andrographolide for pregnant and breastfeeding individuals. Therefore, it is generally recommended that pregnant and breastfeeding women avoid its use.Â
Autoimmune disorders: andrographolide may stimulate the immune system, and in individuals with autoimmune disorders such as rheumatoid arthritis or multiple sclerosis, it could potentially exacerbate the condition.Â
Bleeding disorders: andrographolide may have anticoagulant (blood-thinning) properties, and its use should be cautious in individuals with bleeding disorders or those taking medications that affect blood clotting.Â
Pregnancy warnings:    Â
Pregnancy category: N/AÂ
Lactation: Excreted into human milk is unknownÂ
Pregnancy Categories:        Â
Category A: Studies that were well-controlled and met expectations revealed no risk to the fetus in either the first or second trimester.Â
<b>Category B: There were a lack of studies on pregnant women and no evidence of risk to the fetus in animal experiments.  Â
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.   Â
Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.  Â
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.   Â
Category N: There is no data available for the drug under this category
Pharmacology: andrographolide is a bioactive compound found in the plant andrographis paniculate.Â
Pharmacodynamics:Â Â
Anti-Inflammatory Activity:Â
andrographolide demonstrates significant anti-inflammatory characteristics through its ability to suppress the synthesis of pro-inflammatory cytokines, such as tumor necrosis factor-alpha. (TNF-α), interleukin-6 (IL-6), and interleukin-1β (IL-1β). It suppresses the activation of nuclear factor-kappa B (NF-ÎşB), a key transcription factor involved in the inflammatory response.Â
Immunomodulatory Effects:Â
andrographolide can improve immune system performance by maximizing immune cell activity like lymphocytes & macrophages. It promotes the production of antibodies and has been studied for its potential use in autoimmune disorders.Â
Pharmacokinetics:Â
AbsorptionÂ
andrographolide is poorly absorbed in its natural form due to its low aqueous solubility.Â
The absorption of andrographolide may be improved when it is administered as a formulated extract that enhances its bioavailability.Â
DistributionÂ
Once absorbed, andrographolide is distributed throughout the body.Â
It has been found in various tissues and organs, indicating a wide distribution profile.Â
MetabolismÂ
andrographolide undergoes metabolism in the liver, primarily through the action of cytochrome P450 enzymes.Â
Excretion and EliminationÂ
The elimination of andrographolide and its metabolites occurs primarily through the kidneys.Â
It is excreted in the urine and possibly in feces, depending on the specific chemical modifications during metabolism.Â
Administration: Â
Oral Supplementation:Â
andrographolide is often available in the form of capsules, tablets, or softgels. The recommended dosage can vary; thus, it’s critical to adhere to the detailed directions on the product label or those recommended by a medical practitioner.Â
Liquid Extract:Â
andrographolide can be consumed in liquid form as an herbal extract. The dosage should be determined according to the concentration of andrographolide in the extract.
Patient information leafletÂ
Generic Name: andrographolideÂ
Why do we use andrographolide? Â
andrographolide has been shown to have anti-inflammatory properties; it is used to treat various inflammatory diseases, including arthritis and IBD. It is believed to enhance the immune system’s response to infections, making it a popular remedy for treating respiratory infections.Â
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